Journal of Community Hospital Internal Medicine Perspectives,
Год журнала:
2023,
Номер
13(5)
Опубликована: Сен. 2, 2023
Pulmonary
embolism
(PE)
is
a
serious
medical
condition
that
can
occur
as
result
of
venous
thromboembolism
(VTE).
COVID-19,
also
known
Post-Acute
Sequelae
SARS-CoV-2
infection
(PASC),
potentially
lead
to
PE
due
the
formation
blood
clots
in
lungs.
This
study
aims
collate
and
report
trends
patients
with
long
COVID
(4-12
weeks
since
infection)
post-COVID-19
syndrome
(>12
infection).
The
adhered
PRISMA
Statement
2020
guidelines,
systematic
search
was
conducted
four
databases.
In
total,
nine
observational
studies
were
included
total
patient
count
45,825,187.
incidence
COVID/post-COVID-19
seen
among
31,885
individuals
out
44,967,887
participants.
rate
observed
0.07%,
given
matched
controls.
While
we
cannot
state
certainty
COVID-19
itself
leads
higher
risks
at
later
time,
this
emphasizes
need
for
optimized
care
longitudinal
during
era
account
deviations
from
norm.
Cell Death and Disease,
Год журнала:
2023,
Номер
14(9)
Опубликована: Сен. 6, 2023
The
outbreak
of
Coronavirus
Disease
2019
(COVID-19)
has
prompted
the
scientific
community
to
explore
potential
treatments
or
vaccines
against
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
virus
that
causes
illness.
While
SARS-CoV-2
is
mostly
considered
a
pathogen,
several
neurological
complications
have
been
reported,
raising
questions
about
how
it
may
enter
Central
Nervous
System
(CNS).
Receptors
such
as
ACE2,
CD147,
TMPRSS2,
and
NRP1
identified
in
brain
cells
be
involved
facilitating
entry
into
CNS.
Moreover,
proteins
like
P2X7
Panx-1
contribute
pathogenesis
COVID-19.
Additionally,
role
immune
system
gravity
COVID-19
investigated
with
respect
both
innate
adaptive
responses
caused
by
infection,
which
can
lead
cytokine
storm,
tissue
damage,
manifestations.
A
redox
imbalance
also
linked
COVID-19,
potentially
causing
mitochondrial
dysfunction,
generating
proinflammatory
cytokines.
This
review
summarizes
different
mechanisms
reactive
oxygen
species
neuro-inflammation
development
recent
progress
study
immunological
events
bioinformatics
implications
Frontiers in Cardiovascular Medicine,
Год журнала:
2023,
Номер
9
Опубликована: Янв. 10, 2023
Background
and
purpose
Acute
ischemic
stroke
(AIS)
is
a
fearful
complication
of
Coronavirus
Disease-2019
(COVID-19).
Aims
this
study
were
to
compare
clinical/radiological
characteristics,
endothelial
coagulation
dysfunction
between
acute
patients
with
without
COVID-19
investigate
if
how
the
SARS-CoV-2
spike
protein
(SP)
was
implicated
in
triggering
platelet
activation.
Methods
We
enrolled
AIS
within
12
h
from
onset
compared
them
an
age-
sex-matched
cohort
controls
COVID-19.
Neuroimaging
studies
performed
24
h.
Blood
samples
collected
subset
10
patients.
Results
Of
39
patients,
22
had
17
did
not.
Admission
levels
Factor
VIII
von
Willebrand
factor
antigen
significantly
higher
positively
correlated
infarct
volume.
In
multivariate
linear
regression
analyses,
independent
predictor
volume
(B
20.318,
Beta
0.576,
95%CI
6.077–34.559;
p
=
0.011).
SP
found
serum
2
examined
Platelets
healthy
donors
showed
similar
degree
procoagulant
activation
induced
by
non-COVID-19
patients'
sera.
The
anti-SP
anti-FcγRIIA
blocking
antibodies
no
effect
modulating
activity
both
groups.
Conclusions
infection
seems
play
major
role
endothelium
extension
during
AIS.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
154, С. 113534 - 113534
Опубликована: Авг. 17, 2022
Cerebral
microvascular
disease
has
been
reported
as
a
central
feature
of
the
neurological
disorders
in
patients
with
SARS-CoV-2
infection
that
may
be
associated
an
increased
risk
ischemic
stroke.
The
main
pathomechanism
development
cerebrovascular
injury
due
to
can
consequence
endothelial
cell
dysfunction
structural
part
blood-brain
barrier
(BBB),
which
accompanied
by
inflammatory
response
and
thrombocytopenia
along
blood
coagulation
disorders.
In
this
review,
we
described
properties
BBB,
neurotropism
behavior
SARS-CoV-2,
possible
mechanisms
damage
CNS
upon
infection.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(4), С. 1340 - 1340
Опубликована: Фев. 8, 2023
Coronavirus-19,
primarily
a
respiratory
virus,
also
affects
the
nervous
system.
Acute
ischemic
stroke
(AIS)
is
well-known
complication
among
COVID-19
infections,
but
large-scale
studies
evaluating
AIS
outcomes
related
to
infection
remain
limited.
We
used
National
Inpatient
Sample
database
compare
acute
patients
with
and
without
COVID-19.
A
total
of
329,240
were
included
in
study:
(n
=
6665,
2.0%)
322,575,
98.0%).
The
primary
outcome
was
in-hospital
mortality.
Secondary
mechanical
ventilation,
vasopressor
use,
thrombectomy,
thrombolysis,
seizure,
venous
thromboembolism,
myocardial
infarction,
cardiac
arrest,
septic
shock,
kidney
injury
requiring
hemodialysis,
length
stay,
mean
hospitalization
charge,
disposition.
who
COVID-19-positive
had
significantly
increased
mortality
compared
(16.9%
vs.
4.1%,
aOR:
2.5
[95%
CI
1.7-3.6],
p
<
0.001).
This
cohort
ventilation
injury,
charge.
Further
research
regarding
vaccination
therapies
will
be
vital
reducing
worse
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(18), С. 11823 - 11823
Опубликована: Сен. 19, 2022
Since
the
very
beginning
of
COVID-19
pandemic,
numerous
researchers
have
made
an
effort
to
determine
molecular
composition
SARS-CoV-2
virus,
and
exact
pathomechanism
through
which
virus
exerts
such
a
devastating
effect
on
host/infected
organism.
Recent
scientific
evidence
highlights
affinity
towards
ACE2
receptors,
are
widespread
in
multiple
human
systems,
including
central
nervous
system
(CNS)
cerebral
vessels.
Such
may
explain
endothelial
dysfunction
damage
that
is
observed
COVID-positive
patients
histopathological
studies,
with
subsequent
dysregulation
circulation
leading
transient
or
acute
cerebrovascular
accidents.
In
this
paper,
we
aimed
evaluate
effects
COVID-related
hypoxemia
direct
viral
invasion
circulation,
special
respect
postulated
pathomechanism,
vulnerable
groups
patients,
clinical
course
outcomes,
as
well
diagnostic
imaging
findings.
ESC Heart Failure,
Год журнала:
2022,
Номер
10(2), С. 1422 - 1425
Опубликована: Ноя. 8, 2022
This
case
study
aimed
to
identify
rare
viral
myocarditis
combined
with
encephalitis
as
a
COVID-19
vaccine
complication.
A
59-year-old
male
patient
2
day
history
of
headache
and
rapidly
progressive
cognitive
decline,
who
had
received
the
third
dose
12
days
before,
was
admitted
our
hospital.
The
no
underlying
systemic
conditions,
prior
medical
history,
infection.
diagnosed
by
two
neurologists
cardiologists
after
laboratory
examination,
head
computed
tomography,
magnetic
resonance
imaging
evaluation.
experienced
cardiogenic
shock
developed
severe
arrhythmia,
resulting
in
his
death
10
h
admission.
Clinically
suspected
lethal
could
be
related
vaccination.
Adverse
effects
Chinese
vaccine,
especially
serious
complications,
have
been
uncommon.
highlights
complication
vaccination
that
needs
high
attention.
