Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 4, 2023
Abstract
Background
Dietary
patterns
are
strongly
correlated
with
chronic
inflammation.
Inflammatory
processes
play
a
crucial
role
in
maintaining
renal
homeostasis
and
function.
The
dietary
inflammatory
potential
can
be
assessed
through
the
Index
(DII),
which
has
shown
positive
association
higher
likelihood
of
kidney
disease
(CKD)
healthy
individuals.
However,
applicability
DII
assessing
atherosclerotic
cardiovascular
(ASCVD)
patients
not
been
evaluated.
Methods
This
cross-sectional
study
enrolled
3,599
adult
participants
ASCVD
taken
from
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
between
1999
2018.
Systematic
collection
baseline
data
was
performed
for
all
participants.
Patients
were
categorized
into
four
groups
according
to
DII.
function
score
using
linear
regression
analysis.
Multivariable
logistic
investigate
correlation
CKD.
Furthermore,
restricted
cubic
spline
(RCS)
analysis
employed
explore
non-linear
correlations
Results
In
models
adjusted
range
possible
confounders,
demonstrated
serum
creatinine
(p
<
0.001)
an
inverse
estimated
glomerular
filtration
rate
calculated
MDRD
equation
0.001).
Compared
individuals
without
CKD,
those
CKD
had
significantly
elevated
scores
revealed
significant
high
CKD;
after
classifying
quartiles
fully
adjusting,
highest
quartile
(quartile
4)
showed
increased
risk
compared
lowest
1)
(95%
CI:
1.045–1.613,
P
=
0.019).
Using
analysis,
relationship
uncovered
developing
Conclusion
utilized
assess
adults
diagnosed
ASCVD.
findings
that
associated
decreased
independent
factor
development
Our
underscore
importance
diet
low
reduce
this
population.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 8, 2024
Background
systemic
inflammation
disorders
were
observed
in
chronic
kidney
disease
(CKD).
Whether
the
inflammatory
indicators
could
be
optimal
predictors
for
survival
of
CKD
remains
less
studied.
Methods
In
this
study,
participants
selected
from
datasets
National
Health
and
Nutrition
Examination
Survey
(NHANES)
between
1999
to
2018
years.
Four
evaluated
by
peripheral
blood
tests
including
immune-inflammation
index
(SII,
platelet*neutrophil/lymphocyte),
neutrophil-to-lymphocyte
ratio
(NLR),
platelet-to-lymphocyte
(PLR),
lymphocyte-to-monocyte
(LMR).
Kaplan-Meier
curves,
restricted
cubic
spline
(RCS),
Cox
regression
analysis
used
evaluate
association
with
all-cause
mortality
CKD.
Receiver
operating
characteristic
(ROC)
concordance
(C-index)
determine
predictive
accuracy
varied
indicators.
Sensitive
analyses
conducted
validate
robustness
main
findings.
Results
A
total
6,880
included
study.
The
mean
age
was
67.03
years
old.
Among
study
population,
levels
588.35
SII,
2.45
NLR,
133.85
PLR,
3.76
LMR,
respectively.
PLR
all
significantly
positively
associated
patients,
whereas
high
value
LMR
played
a
protectable
role
patients.
NLR
leading
patients
[Hazard
(HR)
=1.21,
95%
confidence
interval
(CI):
1.07-1.36,
p
=
0.003
(3
rd
quartile),
HR
1.52,
95%CI:
1.35-1.72,
p<0.001
(4
th
quartile)
0.83,
0.75-0.92,
(2
nd
0.73,
0.65-0.82,
0.74,
0.65-0.83,
LMR],
C-index
0.612
0.624,
RCS
curves
showed
non-linearity
risk
population.
Conclusion
Our
highlights
that
are
important
predicting
U.S.
population
would
add
additional
clinical
health
care
Basic Research in Cardiology,
Год журнала:
2023,
Номер
118(1)
Опубликована: Июль 26, 2023
The
heterocellular
nature
of
the
heart
has
been
receiving
increasing
attention
in
recent
years.
In
addition
to
cardiomyocytes
as
prototypical
cell
type
heart,
non-myocytes
such
endothelial
cells,
fibroblasts,
or
immune
cells
are
coming
more
into
focus.
rise
single-cell
sequencing
technologies
enables
identification
ever
subtle
differences
and
reignited
question
what
defines
a
cell's
identity.
Here
we
provide
an
overview
major
cardiac
types,
describe
their
roles
homeostasis,
outline
findings
on
non-canonical
functions
that
may
be
relevance
for
cardiology.
We
highlight
modes
biochemical
biophysical
interactions
between
different
types
discuss
potential
implications
basic
research
therapeutic
interventions.
Journal of the American Heart Association,
Год журнала:
2024,
Номер
13(9)
Опубликована: Май 3, 2024
The
only
clinically
approved
drug
that
reduces
doxorubicin
cardiotoxicity
is
dexrazoxane,
but
its
application
limited
due
to
the
risk
of
secondary
malignancies.
So,
exploring
alternative
effective
molecules
attenuate
crucial.
Colchicine
a
safe
and
well-tolerated
helps
reduce
production
reactive
oxygen
species.
High
doses
colchicine
have
been
reported
block
fusion
autophagosomes
lysosomes
in
cancer
cells.
However,
impact
on
autophagy
activity
within
cardiomyocytes
remains
inadequately
elucidated.
Recent
studies
highlighted
beneficial
effects
patients
with
pericarditis,
postprocedural
atrial
fibrillation,
coronary
artery
disease.
It
ambiguous
how
regulates
autophagic
flux
doxorubicin-induced
heart
failure.
Biomedicines,
Год журнала:
2023,
Номер
11(11), С. 3033 - 3033
Опубликована: Ноя. 12, 2023
Chronic
kidney
disease
(CKD)
is
a
severe
condition
and
significant
public
health
issue
worldwide,
carrying
the
burden
of
an
increased
risk
cardiovascular
events
mortality.
The
traditional
factors
that
promote
onset
progression
CKD
are
cardiometabolic
like
hypertension
diabetes,
but
non-traditional
contributors
escalating.
Moreover,
gut
dysbiosis,
inflammation,
impaired
immune
response
emerging
as
crucial
mechanisms
in
pathology.
microbiome
exert
reciprocal
influence
commonly
referred
to
"the
gut-kidney
axis"
through
induction
metabolic,
immunological,
endocrine
alterations.
Periodontal
diseases
strictly
involved
axis
for
their
impact
on
microbiota
composition
metabolic
immunological
alterations
occurring
reciprocally
affecting
both
conditions.
This
review
aims
provide
overview
dynamic
biological
interconnections
between
oral
status,
gut,
renal
pathophysiology,
spotlighting
oral-gut-kidney
raising
whether
periodontal
can
be
modifiers
CKD.
By
doing
so,
we
try
offer
new
insights
into
therapeutic
strategies
may
enhance
clinical
trajectory
patients,
ultimately
advancing
our
quest
improved
patient
outcomes
well-being.
Immunological Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Янв. 31, 2025
Recent
evidence
indicates
an
increased
risk
of
chronic
kidney
disease
(CKD)
in
patients
with
rheumatoid
arthritis
(RA),
prevalence
rates
ranging
from
20.8%
to
24.5%.
Risk
factors
for
CKD
among
RA
include
advancing
age,
diabetes,
cardiovascular
disease,
hypertension
and
activity.
Medications
such
as
glucocorticoids
nonsteroidal
anti-inflammatory
drugs
(NSAIDs)
may
also
accelerate
progression.
Inflammatory
cytokines,
notably
interleukin-6
(IL-6),
tumor
necrosis
factor-α
(TNF-α)
IL-1,
play
significant
roles
the
pathogenesis
both
CKD,
promoting
systemic
inflammation
renal
impairment.
Elevated
levels
various
cytokines
have
been
detected
plasma
urine
patients,
they
raise
morbidity
mortality
rates,
even
during
early
stages.
Effective
management
activity
modifications
treatment
reduce
burden
are
essential
lowering
improving
patient
outcomes.
Biological
disease-modifying
antirheumatic
(DMARDs),
particularly
those
targeting
IL-6
TNF-α,
show
potential
mitigating
progression
patients.
However,
individualized
careful
function
monitoring
critical,
impact
management.
Future
research
should
focus
on
therapeutic
strategies
that
address
optimize
care.
Frontiers in Medicine,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 17, 2025
Chronic
kidney
disease
(CKD)
is
a
global
public
health
problem,
and
the
absence
of
reliable
accurate
diagnostic
monitoring
tools
contributes
to
delayed
treatment,
impacting
patients'
quality
life
increasing
treatment
costs
in
health.
Proteomics
using
saliva
key
strategy
for
identifying
potential
biomarkers.
We
analyzed
untargeted
proteomic
profiles
samples
from
20
individuals
with
end-stage
(ESKD)
(n
=
10)
healthy
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
identify
biomarkers
CKD.
A
volcano
plot
was
generated
p-value
≤0.05
fold
change
(FC)
≥
2.0.
Multivariate
analysis
performed
generate
orthogonal
partial
least
squares
discriminant
(OPLS-DA)
model
variable
importance
projection
(VIP)
scores.
The
accuracy
candidate
biomarker
proteins
evaluated
receiver
operating
characteristic
(ROC)
curves.
In
total,
431
were
identified
salivary
profile,
3
significantly
different
between
groups:
apoptosis
inhibitor
5
(API5),
phosphoinositide
phospholipase
C
(PI-PLC),
small
G
protein
signaling
modulator
2
(Sgsm2).
These
showed
good
based
on
ROC
curve
VIP
score
>2.0.
During
pathway
enrichment,
PI-PLC
participates
synthesis
IP3
IP4
cytosol.
Gene
ontology
(GO)
revealed
data
molecular
functions,
biological
processes,
cellular
components,
classes.
can
conclude
that
API5,
PI-PLC,
Sgsm2
be
candidates
CKD
detection.
may
participate
pathways
related
renal
fibrosis
other
associated
diseases,
such
as
mineral
bone
disorders.
