In
response
to
various
stressors,
cardiac
chambers
undergo
structural
remodeling.
Long-term
exposure
of
the
right
ventricle
(RV)
pressure
or
volume
overload
leads
its
maladaptive
remodeling,
associated
with
RV
failure
and
increased
mortality.
While
left
ventricular
adverse
remodeling
is
well
understood
therapeutic
options
are
available
emerging,
remains
underexplored
no
specific
therapies
currently
available.
Accumulating
evidence
implicates
a
role
mast
cells
in
Mast
produce
release
numerous
inflammatory
mediators,
growth
factors
proteases
that
can
adversely
affect
cells,
thus
contributing
Recent
experimental
findings
suggest
might
represent
potential
target.
This
review
examines
focus
on
explores
efficacy
interventions
targeting
mitigate
Basic Research in Cardiology,
Год журнала:
2024,
Номер
119(1), С. 1 - 33
Опубликована: Янв. 3, 2024
Despite
the
advances
in
treatment
options,
cardiovascular
disease
(CVDs)
remains
leading
cause
of
death
over
world.
Chronic
inflammatory
response
and
irreversible
fibrosis
are
main
underlying
pathophysiological
causes
progression
CVDs.
In
recent
decades,
cardiac
macrophages
have
been
recognized
as
regulatory
players
development
these
complex
conditions.
Numerous
approaches
aimed
at
devised,
to
novel
prospects
for
therapeutic
interventions.
Our
review
covers
advancements
macrophage-centric
plans
various
pathologic
conditions
examines
potential
consequences
obstacles
employing
macrophage-targeted
techniques
diseases.
Basic Research in Cardiology,
Год журнала:
2023,
Номер
118(1)
Опубликована: Авг. 24, 2023
Activation
of
signal
transducer
and
activator
transcription
3
(STAT3)
has
been
identified
as
a
key
cardioprotective
not
only
in
animal
studies
but
also
humans-in
animals,
STAT3
is
causally
involved
cardioprotection.
In
response
to
late
ischemic
conditioning,
canonical
function
activation
upregulates
the
expression
anti-apoptotic
proteins.
its
non-canonical
function,
activated
during
conditioning
part
cytosolic
survival
activating
factor
enhancement
pathway.
Activated
imported
localized
mitochondria.
Mitochondrial
stimulates
activity
mitochondrial
electron
transport
chain
complex
I,
reduces
reactive
oxygen
species
production
permeability
transition
pore
opening.
Finally,
two
novel
aspects
STAT
cardioprotection
are
discussed:
genetic
variance
encoding
region
potential
primordial
confounding
variable
for
cardioprotection,
sodium-glucose
cotransporter
2
inhibitors
through
activation.
Organ
damage
or
failure
arising
from
injury,
disease,
and
aging
poses
challenges
due
to
the
body's
limited
regenerative
capabilities.
transplantation
presents
issues
of
donor
shortages
immune
rejection
risks,
necessitating
innovative
solutions.
The
3D
bioprinting
organs
on
demand
offers
promise
in
tissue
engineering
medicine.
In
this
review,
we
explore
state-of-the-art
technologies,
with
a
focus
bioink
cell
type
selections.
We
follow
discussions
advances
solid
organs,
such
as
heart,
liver,
kidney,
pancreas,
highlighting
importance
vascularization
integration.
Finally,
provide
insights
into
key
future
directions
context
clinical
translation
bioprinted
their
large-scale
production.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 1025 - 1041
Опубликована: Фев. 1, 2025
Cardiac
or
myocardial
dysfunction
induced
by
sepsis,
known
as
sepsis-induced
cardiomyopathy
injury
(SIMI),
is
a
common
complication
of
sepsis
and
associated
with
poor
outcomes.
However,
the
pathogenesis
molecular
mechanisms
underlying
SIMI
remain
poorly
understood,
requiring
further
investigations.
Emerging
evidence
has
shown
that
NOD-,
LRR-,
pyrin
domain-containing
protein
3
(NLRP3)
inflammasomes
contribute
to
SIMI.
Compounds
inhibit
NLRP3-associated
pyroptosis
may
exert
therapeutic
effects
against
In
this
review,
we
first
outlined
principal
elements
NLRP3
signaling
cascade
summarized
recent
studies
highlighting
how
activation
contributes
We
selective
small-molecule
modulators
function
inhibitors
delineated
their
action
attenuate
Finally,
discuss
major
limitations
current
paradigm
propose
possible
strategies
overcome
them.
This
review
highlights
pharmacological
inhibition
promising
strategy.
AJP Heart and Circulatory Physiology,
Год журнала:
2023,
Номер
325(3), С. H475 - H491
Опубликована: Июль 7, 2023
Although
cardiac
action
potential
(AP)
generation
and
propagation
have
traditionally
been
attributed
exclusively
to
cardiomyocytes
(CM),
other
cell
types
in
the
heart
are
also
capable
of
forming
electrically
conducting
junctions.
Interactions
between
CM
nonmyocytes
(NM)
enable
modulate
each
other’s
activity.
This
review
provides
an
overview
current
understanding
heterocellular
electrical
communication
heart.
fibroblasts
were
initially
thought
be
insulators,
recent
studies
demonstrated
that
they
form
functional
connections
with
situ.
Other
NM,
such
as
macrophages,
recognized
contributing
electrophysiology
arrhythmogenesis.
Novel
experimental
tools
enabled
investigation
cell-specific
activity
patterns
native
tissue,
which
is
expected
yield
exciting
new
insights
into
development
novel
or
improved
diagnostic
therapeutic
strategies.
Basic Research in Cardiology,
Год журнала:
2024,
Номер
119(2), С. 243 - 260
Опубликована: Фев. 8, 2024
Abstract
Inflammaging,
a
pro-inflammatory
status
that
characterizes
aging
and
primarily
involving
macrophages,
is
master
driver
of
age-related
diseases.
Mineralocorticoid
receptor
(MR)
activation
in
macrophages
critically
regulates
inflammatory
fibrotic
processes.
However,
macrophage-specific
mechanisms
the
role
macrophage
MR
for
regulation
inflammation
remodeling
heart
have
not
yet
been
elucidated.
Transcriptome
profiling
cardiac
from
male/female
young
(4
months-old),
middle
(12
months-old)
old
(18
24
mice
revealed
myeloid
cell-restricted
deficiency
prevents
differentiation
toward
phenotype.
Pathway
enrichment
analysis
showed
several
biological
processes
related
to
cell
metabolism
were
modulated
by
aged
macrophages.
Further,
transcriptome
fibroblasts
reduced
pathways
upregulation
ZBTB16,
transcription
factor
involved
fibrosis.
Phenotypic
characterization
progressive
replacement
TIMD4
+
MHC-II
neg/low
population
int/high
–
heart.
By
integrating
sorting
transwell
experiments
with
/TIMD4
flox
/MR
LysMCre
hearts,
we
crosstalk
between
may
imply
release
mitochondrial
superoxide
anions.
Macrophage
expansion
emergence
niches
heart,
thereby
protecting
against
inflammation,
fibrosis,
dysfunction.
This
study
highlights
as
an
important
mediator
inflammaging
remodeling.
Cardiovascular Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 26, 2024
In
the
last
20
years
there
has
been
a
revolution
in
our
understanding
of
how
blood
flow
is
regulated
many
tissues.
Whereas
it
used
to
be
thought
that
essentially
all
control
occurred
at
arteriole
level,
now
recognised
capillary
by
contractile
pericytes
plays
key
role
both
regulating
physiologically
and
reducing
clinically-relevant
pathological
conditions.
this
article
we
compare
contrast
brain
cardiac
regulate
cerebral
coronary
flow,
focusing
mainly
on
events
ischemia.
The
beds
differ
dramatically
morphology,
yet
cases
pericyte-mediated
constriction
restricting
after
ischemia
possibly
other
We
conclude
with
suggestions
for
therapeutic
approaches
relaxing
pericytes,
which
may
prove
useful
long
term
pericyte-induced
Basic Research in Cardiology,
Год журнала:
2024,
Номер
119(3), С. 453 - 479
Опубликована: Март 15, 2024
Abstract
Though
myocardial
infarction
(MI)
in
pigs
is
a
well-established
translational
large
animal
model,
it
has
not
yet
been
widely
used
for
immunotherapy
studies,
and
comprehensive
description
of
the
immune
response
to
MI
this
species
lacking.
We
induced
Landrace
by
balloon
occlusion
left
anterior
descending
artery
over
90
min.
Within
14
days,
necrotic
myocardium
was
progressively
replaced
scar
tissue
with
involvement
myofibroblasts.
characterized
heart
ex
vivo
(immuno)histology,
flow
cytometry,
RNA
sequencing
on
days
3,
7,
after
MI.
Besides
clear
predominance
myeloid
cells
among
heart-infiltrating
leukocytes,
we
detected
activated
T
an
increasing
proportion
CD4
+
Foxp3
regulatory
(T
reg
),
especially
infarct
core—findings
that
closely
mirror
what
observed
mice
humans
Transcriptome
data
indicated
inflammatory
activity
persistent
but
markedly
changing
character
time
linked
extracellular
matrix
biology.
Analysis
lymphocytes
heart-draining
lymph
nodes
revealed
significantly
higher
proliferation
rates
helper
cell
subsets,
including
day
7
MI,
compared
sham
controls.
Elevated
frequencies
progenitors
spleen
suggest
might
be
site
emergency
myelopoiesis
pigs,
as
previously
shown
mice.
thus
provide
first
our
results
can
aid
future
research
using
preclinical
studies.
JACC Advances,
Год журнала:
2025,
Номер
4(2), С. 101528 - 101528
Опубликована: Фев. 1, 2025
The
Canadian
Cardiovascular
Society
recently
put
forth
a
new
classification
of
acute
reperfused
myocardial
infarction
(MI)
based
on
stages
injury.
Backed
by
more
than
5
decades
intense
investigation
in
the
field,
key
message
this
is
that
not
all
MIs
are
same
and
type
extent
injury
should
be
considered
diagnosing
treating
MI.
We
review
literature
with
goal
highlighting
progressive
advances
enabled
synthesis
into
4
distinct
tissue
emphasize
major
breakthroughs
from
insights
gained
experimental,
translational,
clinical
studies
to
date.
also
identify
current
gaps
knowledge
critical
research
directions
need
pursued
improve
patient
care
reduce
post-MI
complications
such
as
chronic
heart
failure
malignant
arrhythmias,
whose
risk
linked
stage
