Prognostic Factors Associated with Acute Heart Failure in Patients Admitted for COVID-19: Analysis of the SEMI-COVID-19 Registry DOI Open Access
Manuel Méndez‐Bailón, Noël Lorenzo Villalba,

Jorge Garcia Onrubia

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(14), С. 4649 - 4649

Опубликована: Июль 12, 2023

Since the beginning of COVID-19 pandemic in March 2020, an intimate relationship between this disease and cardiovascular diseases has been seen. However, few studies assess development heart failure during infection. This study aims to determine predisposing factors for (HF) hospital admission patients.A retrospective multicenter patients with HF admitted 150 Spanish hospitals (SEMI-COVID-19 Registry). A bivariate analysis was performed relate different variables evaluated developing admission. multivariate including most relevant clinical obtained analyses predict outcome performed.A total 16.474 hospitalized were included (57.5% men, mean age 67 years), 958 them (5.8%) developed hospitalization. The risk were: (odds ratio [OR]): 1.042; confidence interval 95% (CI 95%): 1.035-1.050; p < 0.001), atrial fibrillation (OR: 2.022; CI 95%: 1.697-2.410; BMI > 30 kg/m2 1.460 1.230-1.733; 0001), peripheral vascular 1.564; 1.217-2.201; 0.001). Patients who had a higher rate mortality (54.1% vs. 19.1%, intubation 2,36; ICU admissions 2.38; 0001).Patients presented older factors. age, fibrillation, obesity, disease. In addition, more frequently required be intubated or ICU.

Язык: Английский

Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19 DOI Creative Commons
Jacopo Sabbatinelli, Mirko Di Rosa, Angelica Giuliani

и другие.

Mechanisms of Ageing and Development, Год журнала: 2023, Номер 216, С. 111876 - 111876

Опубликована: Окт. 4, 2023

Elevation of cardiac damage biomarkers is associated with adverse clinical outcomes and increased mortality in COVID-19 patients. This study assessed the association admission serum levels sST2 H-FABP in-hospital 191 geriatric patients (median age 86 yrs., IQR 82-91 yrs.) available measures hs-cTnT NT-proBNP at admission. Cox proportional hazards models were utilized to predict mortality, considering clinical/biochemical confounders as covariates. A composite score was calculated improve predictive accuracy. Patients deceased during their hospital stay (26%) exhibited higher all biomarkers, which demonstrated good discrimination for mortality. Addition significantly improved discriminatory power NT-proBNP. The (AUC=0.866) further enhanced Crude adjusted regressions revealed that both independently (HR ≥129 ng/mL, 4.32 [1.48–12.59]; HR ≥18 7.70 [2.12–28.01]). also correlated 1-unit increase, 1.47 [1.14–1.90]). In older COVID-19, prognostic value, improving accuracy routinely

Язык: Английский

Процитировано

2
Proinflammatory cytokines set the stage for cardiac damage DOI Open Access
DiyaaElDin Ashour, Gustavo Ramos

Cardiovascular Research, Год журнала: 2024, Номер 120(2), С. 109 - 110

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Myocardial Work Indices in Patients Recently Recovered from Mild-to-Moderate COVID-19 DOI Open Access
Rafał Dankowski, Wioletta Sacharczuk,

Julita Fedorowicz

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(14), С. 4090 - 4090

Опубликована: Июль 12, 2024

Background/Objectives: Persistent cardiovascular issues are common in COVID-19 survivors, making the detection of subtle myocardial injuries critical. This study evaluates work (MW) indices patients recently recovering from mild-to-moderate COVID-19. Methods: A total 105 recovered (who had a mean age 52 years) underwent comprehensive laboratory testing and advanced echocardiographic assessments. The median time since their infections was 56 days (IQR: 42–71). cohort stratified based on high-sensitive troponin I (hs-TnI) levels: undetectable versus detectable. analysis utilized pressure-strain loops to evaluate MW indices. Results: Detectable hs-TnI levels were observed 42% patients. values for entire group slightly below normal values: global index (GWI)—1834 mmHg% (IQR 1168–2054 mmHg%), constructive (GCW)—2130 2010–2398 wasted (GWW)—119 78–175 efficiency (GWE)—94% 92–96%). Patients with detectable higher GWW (168 vs. 97 mmHg%, p < 0.005) lower GWE (93% 95%, 0.005). In multiple regression analysis, strain dispersion (PSD) sole predictor (β = 0.67, 0.001), while GWE, PSD −0.67, 0.001) LVEF 0.16, 0.05) significant predictors. Conclusions: Among COVID-19, elevated linked reduction an increase GWW. is important inefficiency work. this group, disruptions timing coordination cardiac muscle contractions may play key pathophysiological role reducing heart’s performance.

Язык: Английский

Процитировано

0
Development of a novel machine learning model based on laboratory and imaging indices to predict acute cardiac injury in cancer patients with COVID-19 infection: a retrospective observational study DOI

G. Wan,

Xuefeng Wu, Xiaowei Zhang

и другие.

Journal of Cancer Research and Clinical Oncology, Год журнала: 2023, Номер 149(19), С. 17039 - 17050

Опубликована: Сен. 25, 2023

Язык: Английский

Процитировано

1
Viral infections in cardiometabolic risk and disease between old acquaintances and new enemies DOI Creative Commons
Cristina Vassalle

Опубликована: Дек. 27, 2023

Atherosclerosis is a chronic disease, characterized by inflammation, endothelial dysfunction, and lipid deposition in the vessel. Although many major, well-identified risk factors for atherosclerosis [e.g., hyperlipidemia, hypertension, type 2 diabetes (T2D), smoking habit, obesity] explain lot about risk, there considerable number of patients who develop atherosclerotic damage undergo adverse events without presenting any these established modifiable factors. This observation has stimulated an urgent need to expand knowledge towards identification additional, less that may help assessment fill gap cardiovascular (CV) setting. Among them, hypothesis possible relationship between viral infectious agents risen since early 1900s. However, still great deal debate regarding onset progression CV disease relation roles pathogens (as active inducers or bystanders), host genomic counterparts, environmental triggers, affecting both virus abundance composition communities. Accordingly, aim this review discuss current state on process, with particular focus two environmental-related viruses, as examples familiar (influenza) unfamiliar [severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)] triggers.

Язык: Английский

Процитировано

1
COVID-19 and the Cardiovascular System: Requiem for a Medical Minotaur DOI Open Access
Milka Koupenova,

Mina K. Chung,

Michael R. Bristow

и другие.

Circulation Research, Год журнала: 2023, Номер 132(10), С. 1255 - 1258

Опубликована: Май 11, 2023

Язык: Английский

Процитировано

0
Prognostic Factors Associated with Acute Heart Failure in Patients Admitted for COVID-19: Analysis of the SEMI-COVID-19 Registry DOI Open Access
Manuel Méndez‐Bailón, Noël Lorenzo Villalba,

Jorge Garcia Onrubia

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(14), С. 4649 - 4649

Опубликована: Июль 12, 2023

Since the beginning of COVID-19 pandemic in March 2020, an intimate relationship between this disease and cardiovascular diseases has been seen. However, few studies assess development heart failure during infection. This study aims to determine predisposing factors for (HF) hospital admission patients.A retrospective multicenter patients with HF admitted 150 Spanish hospitals (SEMI-COVID-19 Registry). A bivariate analysis was performed relate different variables evaluated developing admission. multivariate including most relevant clinical obtained analyses predict outcome performed.A total 16.474 hospitalized were included (57.5% men, mean age 67 years), 958 them (5.8%) developed hospitalization. The risk were: (odds ratio [OR]): 1.042; confidence interval 95% (CI 95%): 1.035-1.050; p < 0.001), atrial fibrillation (OR: 2.022; CI 95%: 1.697-2.410; BMI > 30 kg/m2 1.460 1.230-1.733; 0001), peripheral vascular 1.564; 1.217-2.201; 0.001). Patients who had a higher rate mortality (54.1% vs. 19.1%, intubation 2,36; ICU admissions 2.38; 0001).Patients presented older factors. age, fibrillation, obesity, disease. In addition, more frequently required be intubated or ICU.

Язык: Английский

Процитировано

0