Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction

Angiogenesis, Год журнала: 2024, Номер 27(4), С. 623 - 639

Опубликована: Июль 26, 2024

Abstract As a vital component of blood vessels, endothelial cells play key role in maintaining overall physiological function by residing between circulating and semi-solid tissue. Various stress stimuli can induce injury, leading to the onset corresponding diseases body. In recent years, importance mitochondria vascular injury has become increasingly apparent. Mitochondria, as primary site cellular aerobic respiration organelle for “energy information transfer,” detect cell damage integrating receiving various external signals. The generation reactive oxygen species (ROS) mitochondrial dysfunction often determine evolution towards necrosis or apoptosis. Therefore, are closely associated with function, helping progression clinical diseases. This article comprehensively reviews interconnection pathogenesis mitochondrial-induced cardiovascular diseases, renal pulmonary-related cerebrovascular microvascular diabetes. Corresponding therapeutic approaches also provided. Additionally, strategies using drugs treat injury-based discussed, aiming offer new insights treatment options diagnosis related injuries.

Язык: Английский

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Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics

Circulation Research, Год журнала: 2025, Номер 136(5), С. 524 - 550

Опубликована: Фев. 27, 2025

Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.

Язык: Английский

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Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 18, 2025

Язык: Английский

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Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology

Biomimetics, Год журнала: 2025, Номер 10(2), С. 73 - 73

Опубликована: Янв. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Язык: Английский

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The epithelial barrier theory and its associated diseases

Allergy, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Abstract The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, 350,000 new chemical substances have introduced to lives humans. In recent years, epithelial barrier theory came light explaining growing and exacerbations these worldwide. It attributes their onset a functionally impaired triggered by toxicity exposed substances, associated with microbial dysbiosis, immune system activation, inflammation. Diseases encompassed share common features such as an increased after 1960s or 2000s that cannot (solely) be accounted for emergence improved diagnostic methods. Other traits include defects, dysbiosis loss commensals colonization opportunistic pathogens, circulating inflammatory cells cytokines. addition, practically unrelated fulfill criteria started emerge multimorbidities during last Here, we provide comprehensive overview discuss evidence similarities epidemiology, genetic susceptibility, dysfunction, tissue

Язык: Английский

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Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review

Nutrients, Год журнала: 2024, Номер 16(17), С. 2838 - 2838

Опубликована: Авг. 24, 2024

The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds millions years. Over the past decade, growing body knowledge has underscored intricate connections among diet, microbiota, and human health. Bioactive polysaccharides (BPs) from natural sources like medicinal plants, seaweeds, fungi diverse biological functions including antioxidant, immunoregulatory, metabolic activities. Their effects are closely tied to which metabolizes BPs into health-influencing compounds. Understanding how interact is critical for harnessing potential health benefits. This review provides an overview focusing on its role in diseases obesity, type II diabetes mellitus, non-alcoholic fatty liver disease, cardiovascular diseases. It explores basic characteristics several impact microbiota. Given significance health, we summarize these BPs, particularly terms immunoregulatory activities, blood sugar, hypolipidemic effect, thus providing valuable reference understanding benefits treating These properties make promising agents preventing comprehensive mechanisms by exert through opens new avenues developing targeted therapies improve

Язык: Английский

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3‐HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Ischemic stroke is the most common cerebrovascular disease and leading cause of permanent disability worldwide. Recent studies have shown that development prognosis are closely related to abnormal tryptophan metabolism. Here, significant downregulation 3‐hydroxy‐kynurenamine (3‐HKA) in patients animal models identified. Supplementation with 3‐HKA improved long‐term neurological recovery, reduced infarct volume, increased ipsilateral cerebral blood flow after distal middle artery occlusion (MCAO). promoted angiogenesis, functional vessel formation, blood‐brain barrier (BBB) repair. Moreover, inhibited A1‐like (neurotoxic) astrocyte activation but A2‐like (neuroprotective) polarization. Proteomic analysis revealed AIM2 inflammasome stroke, co‐labeling indicated expression typically astrocytes at 7 14 days stroke. Consistently, co‐cultures primary mouse brain microvascular endothelial cells astrocytes, angiogenesis oxygen‐glucose deprivation (OGD). overexpression abrogated 3‐HKA‐driven vascular remodeling vitro vivo, suggesting may regulate astrocyte‐mediated by impeding activation. In conclusion, promote post‐stroke regulating A1/A2 activation, thereby improving supplementation be an efficient therapy for

Язык: Английский

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Gut–X axis

iMeta, Год журнала: 2025, Номер 4(1)

Опубликована: Фев. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Язык: Английский

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Gut microbiota: A bridge between depression and cardiovascular disease-A narrative review

The Microbe, Год журнала: 2025, Номер unknown, С. 100292 - 100292

Опубликована: Март 1, 2025

Язык: Английский

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Pretreatment with Indole-3-Propionic Acid Attenuates Lipopolysaccharide-Induced Cardiac Dysfunction and Inflammation Through the AhR/NF-κB/NLRP3 Pathway

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 5293 - 5309

Опубликована: Авг. 1, 2024

Patients with sepsis frequently develop septic cardiomyopathy, which is known to be closely related excessive inflammatory responses. Indole-3-propionic acid (IPA) a tryptophan metabolite anti-inflammatory properties that have been demonstrated in various studies. In this study, we investigated the underlying mechanisms and therapeutic role of IPA cardiomyopathy.

Язык: Английский

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