Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 12, 2024
Background
Life’s
essential’
8
(LE8)
is
a
newly
updated
cardiovascular
health
(CVH)
metrics
from
the
American
Heart
Association,
with
close
relevance
to
metabolism.
Our
objective
explore
association
between
LE8
scores
and
incidence
of
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
advanced
fibrosis
in
adults.
Methods
This
population-based
cross-sectional
study
utilized
data
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
2005
2018,
encompassing
adults
aged
20
years
or
older.
Validated
non-invasive
scoring
systems
were
employed
define
steatosis
fibrosis.
Multivariable
logistic
regression
smooth
curve
fitting
techniques
applied
evaluate
associations.
All
analyses
adjusted
for
survey’
complex
design
parameters
accounted
sample
weights.
Results
A
total
11,820
participants
included.
higher
score
was
found
be
inversely
associated
MAFLD
fibrosis,
odds
ratios
(OR)
0.64
(95%
CI:
0.57–0.71)
0.75
0.61–0.92)
per
1
standard
deviation
(SD)
increase
score.
Similar
patterns
relationship
behaviors/factors
In
subgroup
analyses,
interaction
test
showed
that
age,
education
level,
marital
status,
CVD,
hypertension
diabetes
had
significant
impact
on
(all
P
<
0.05).
Among
male,
elderly,
wealthy,
other
race,
depression
participants,
correlation
not
statistically
(
>
Younger
exhibited
more
pronounced
negative
CVH
metric
both
life
Conclusion
its
subscales
presence
non-linear
patterns.
Optimal
may
significantly
reduce
risk
BACKGROUND:
The
American
Heart
Association
(AHA),
in
conjunction
with
the
National
Institutes
of
Health,
annually
reports
most
up-to-date
statistics
related
to
heart
disease,
stroke,
and
cardiovascular
risk
factors,
including
core
health
behaviors
(smoking,
physical
activity,
nutrition,
sleep,
obesity)
factors
(cholesterol,
blood
pressure,
glucose
control,
metabolic
syndrome)
that
contribute
health.
AHA
Disease
Stroke
Statistical
Update
presents
latest
data
on
a
range
major
clinical
circulatory
disease
conditions
(including
brain
health,
complications
pregnancy,
kidney
congenital
rhythm
disorders,
sudden
cardiac
arrest,
subclinical
atherosclerosis,
coronary
cardiomyopathy,
failure,
valvular
venous
thromboembolism,
peripheral
artery
disease)
associated
outcomes
quality
care,
procedures,
economic
costs).
METHODS:
AHA,
through
its
Epidemiology
Prevention
Statistics
Committee,
continuously
monitors
evaluates
sources
stroke
United
States
globally
provide
current
information
available
annual
review
published
literature
year
before
writing.
2024
is
product
full
year’s
worth
effort
2023
by
dedicated
volunteer
clinicians
scientists,
committed
government
professionals,
staff
members.
strives
further
understand
help
heal
problems
inflicted
structural
racism,
public
crisis
can
significantly
damage
mental
perpetuate
disparities
access
education,
income,
housing,
several
other
vital
healthy
lives.
This
edition
includes
additional
global
data,
as
well
monitoring
benefits
population,
an
enhanced
focus
equity
across
key
domains.
RESULTS:
Each
chapters
focuses
different
topic
statistics.
CONCLUSIONS:
represents
critical
resource
for
lay
public,
policymakers,
media
clinicians,
care
administrators,
researchers,
advocates,
others
seeking
best
these
conditions.
JAMA Internal Medicine,
Год журнала:
2024,
Номер
184(3), С. 301 - 301
Опубликована: Янв. 29, 2024
Food
insecurity
has
been
linked
to
multiple
causes
of
disease
and
premature
mortality;
however,
its
association
with
mortality
by
sex
across
racial
ethnic
groups
remains
unknown
in
the
US.
The journal of nutrition health & aging,
Год журнала:
2024,
Номер
28(6), С. 100224 - 100224
Опубликована: Апрель 5, 2024
Maintaining
ideal
cardiovascular
health
(CVH)
is
believed
to
have
potential
anti-aging
benefits.
The
American
Heart
Association
(AHA)
recently
updated
the
"Life's
Essential
8
(LE8)"
metrics
measure
CVH,
but
its
connection
with
protein
klotho
still
unclear.
We
aimed
explore
relationship
between
and
serum
in
a
nationally
representative
US
middle-aged
older
population.
A
cross-sectional
study.
National
Health
Nutrition
Examination
Survey
(2007−2016).
total
of
9457
participants.
Ideal
CVH
scores
their
components
were
defined
according
guidelines
set
by
AHA.
Serum
detected
enzyme-linked
immunosorbent
assay.
Weighted
multivariable
linear
regression
restricted
cubic
spline
employed
examine
association
score
klotho.
Subgroup
analyses
conducted,
stratified
age
(40−59
60−79),
sex
(Male
Female),
race
(Mexican
American,
non-Hispanic
White,
Black,
Others)
chronic
kidney
disease
(Yes
No)
fully
adjusted
models.
participants
included
this
study,
mean
55.27
±
0.17
years.
level
population
was
849.33
5.39
pg/mL.
After
controlling
for
confounders,
LE8
showed
positive
correlation
levels
(β:
1.32;
95%
CI
0.73,
1.91),
non-linear
dose-response
observed.
Furthermore,
we
also
discovered
behaviors
factors
0.48;
0.07,
0.88
β:
1.05;
0.54,
1.56,
respectively),
particularly
stronger
In
subgroup
analysis,
observed
significant
interaction
race.
(P
<0.05).
subscale
positively
associated
populations.
Promoting
maintenance
can
contribute
delaying
aging
process.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 5, 2024
Background
Metabolic
syndrome
(MetS)
is
a
global
health
concern,
and
it
particularly
harmful
to
middle-aged
elderly
individuals.
Life
Element
Eight
(LE8),
measure
improve
cardiovascular
health,
may
offer
benefits
for
MetS.
Herein,
we
examined
the
relationship
between
LE8
MetS
among
individuals,
elucidated
role
of
biological
aging
inflammation
in
this
process.
Methods
We
obtained
scores
2,901
Americans,
along
with
their
indicators
(Biological
age,
Phenotypic
Serum
Klotho),
computed
inflammatory
SII,
DII.
Using
logistic
regression
model,
assessed
association
markers,
Biological
aging,
Additionally,
generated
restricted
cubic
spline
(RCS)
plots
display
trends
significant
variables
regression.
parallel
mediation
analysis,
evaluated
possible
mediating
various
factors
risk
Results
Our
examination
revealed
that
higher
were
associated
lower
incidence
fully
adjusted
model.
The
high
subgroup
had
79.73%
reduction
compared
low
an
OR
=
0.2027
(95%
Cl
0.0871,
0.4714),
similar
correlations
factor
risk.
mediated
associations
LE8,
behaviors
Conclusion
A
rise
score
individuals
protective
MetS,
be
partially
by
suggesting
reduce
ameliorating
aging.
Annual Review of Food Science and Technology,
Год журнала:
2024,
Номер
15(1), С. 283 - 305
Опубликована: Июнь 28, 2024
Many
physical,
social,
and
psychological
changes
occur
during
aging
that
raise
the
risk
of
developing
chronic
diseases,
frailty,
dependency.
These
adversely
affect
gut
microbiota,
a
phenomenon
known
as
microbe-aging.
Those
microbiota
alterations
are,
in
turn,
associated
with
development
age-related
diseases.
The
is
highly
responsive
to
lifestyle
dietary
changes,
displaying
flexibility
also
provides
anactionable
tool
by
which
healthy
can
be
promoted.
This
review
covers,
firstly,
main
socioeconomic
factors
modify
composition
function
or
unhealthy
and,
secondly,
advances
being
made
defining
promoting
aging,
including
microbiome-informed
artificial
intelligence
tools,
personalized
patterns,
food
probiotic
systems.
European Journal of Preventive Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
The
impact
of
Life's
Essential
8
(LE8)
on
heart
failure
(HF)
remains
poorly
understood.
We
examined
the
associations
between
three
forms
LE8
measurements
and
HF.
A
total
35
896
participants
without
a
prior
history
HF
from
Kailuan
community
were
included.
status
was
measured
in
2014.
latent
mixture
model
employed
to
identify
trajectories
during
2006
annual
change
rate
defined
as
slope
linear
regression
equation
fitted
by
five
measurements.
Cox
proportional
hazards
models
used
assess
risk
associated
with
LE8,
after
adjusting
for
potential
confounding
variables.
predictive
performance
quantified
compared
using
C-index.
Five
distinct
identified.
461
events
documented
follow-up.
presenting
an
upward
trend
reduced
HF,
even
when
initial
level
low
[HR
(95%
confidence
interval)
moderate-increasing
vs.
moderate-decreasing
trajectory
0.43
(0.34,
0.55)].
inversely
risk.
higher
increase
lower
more
accurate
predicting
status.
Individuals
initially
levels
experienced
reversal
upon
improvement.
Both
are
practicable
identifying
individuals
at
high
may
provide
added
prognostic
information.
Thorax,
Год журнала:
2025,
Номер
unknown, С. thorax - 222473
Опубликована: Янв. 19, 2025
Background
Although
morbidity
and
mortality
are
reportedly
increased
in
individuals
with
preserved
ratio
impaired
spirometry
(PRISm),
little
is
known
about
how
to
optimise
PRISm-related
health.
Aims
Is
Life’s
Essential
8
(LE8)
associated
cardiovascular
PRISm
transition
trajectories?
Methods
Participants
(n=31
943)
complete
data
on
LE8
23
179
two
measurements
were
included
from
the
UK
Biobank.
Eight
health
components
used
create
score
(0–100).
Cox
proportional
hazards
models
assess
associations
of
all-cause,
respiratory
mortality.
Multinomial
logistic
regression
conducted
between
trajectories
PRISm.
Results
Among
participants
PRISm,
3113
(9.75%),
25
254
(79.06%)
3576
(11.19%)
categorised
as
high
(LE8≥80),
moderate
(50≤LE8<80)
low
(LE8<50)
groups,
respectively.
Compared
group,
group
demonstrated
higher
risks
disease
(HR:
2.702,
95%
CI
2.391
3.054)
all-cause
(2.496,
2.082
2.993),
(4.165,
2.672
6.493)
(4.103,
1.866
9.020).
Individuals
(vs
LE8)
had
odds
normal
(OR:
2.238,
1.638
3.057)
lower
0.506,
0.339
0.757).
Conclusion
A
was
related
likelihood
developing
recovery.
Abstract
Objectives
Life's
essential
8
(LE8)
is
an
emerging
approach
for
accessing
and
quantifying
cardiovascular
health
(CVH),
but
the
effect
on
Parkinson's
disease
(PD)
still
unclear.
This
study
aimed
to
elucidate
association
between
LE8
metrics
PD
in
US
adults.
Methods
Data
of
26,975
participants
were
extracted
from
last
7
National
Health
Nutrition
Examination
Survey
(NHANES)
cycles
(2005–2018).
The
calculated
according
American
Heart
Association
criterion,
divided
into
3
groups
using
tertile
range.
Multivariate
logistic
regression
models
constructed
explore
PD.
Sensitivity
analysis
was
conducted
verify
robustness.
A
nonlinear
linkage
evaluated
via
restricted
cubic
spline
(RCS).
stability
this
validated
by
subgroup
interaction
test.
Results
total
eligible
(including
271
cases
26,704
non-PD
cases)
included
study.
multivariate
revealed
a
reverse
continuous
with
ORs
0.97
(unadjusted
model
[95%
CI:
0.96–0.98,
P
<
0.01],
partially
adjusted
0.97–0.98,
fully
0.95–0.98,
0.01]).
Compared
those
low
group,
high
group
0.37
(95%
0.27–0.50,
0.01)
unadjusted
model,
0.51
0.36–0.72,
0.32–0.81,
model.
sensitivity
ensured
robustness
observed
LE8-PD
association.
relationship
(
nonlinearity
RCS
analysis.
showed
that
participants'gender
might
impact
strength
metrics-PD
=
0.029).
Conclusions
CVH,
as
delineated
metrics,
reversely
associated
dose–response
pattern,
more
pronounced
female
compared
male.
These
findings
highlight
potential
guide
targeted
strategies
addressing
gender-based
CVH
disparities,
offering
beneficial
insights
tertiary
prevention
