Exposome in ischaemic heart disease: beyond traditional risk factors

European Heart Journal, Год журнала: 2024, Номер 45(6), С. 419 - 438

Опубликована: Янв. 18, 2024

Abstract Ischaemic heart disease represents the leading cause of morbidity and mortality, typically induced by detrimental effects risk factors on cardiovascular system. Although preventive interventions tackling conventional have helped to reduce incidence ischaemic disease, it remains a major death worldwide. Thus, attention is now shifting non-traditional in built, natural, social environments that collectively contribute substantially burden perpetuate residual risk. Of importance, these complex interact non-linearly unpredictable ways often enhance attributable single or collection factors. For this reason, new paradigm called ‘exposome’ has recently been introduced epidemiologists order define totality exposure The purpose review outline how emerging may occurrence with particular impact long-term different environmental pollutants, socioeconomic psychological factors, along infectious diseases such as influenza COVID-19. Moreover, potential mitigation strategies for both individuals communities will be discussed.

Язык: Английский

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Cardiovascular Imaging, Climate Change, and Environmental Sustainability

Radiology Cardiothoracic Imaging, Год журнала: 2024, Номер 6(3)

Опубликована: Июнь 1, 2024

Environmental exposures including poor air quality and extreme temperatures are exacerbated by climate change associated with adverse cardiovascular outcomes. Concomitantly, the delivery of health care generates substantial atmospheric greenhouse gas (GHG) emissions contributing to crisis. Therefore, cardiac imaging teams must be aware not only effects change, but also downstream environmental ramifications imaging. The purpose this review is highlight impact on health, discuss imaging, describe opportunities improve sustainability MRI, CT, echocardiography, nuclear invasive Overarching strategies in include prioritizing tests lower GHG when more than one test appropriate, reducing low-value turning equipment off use. Modality-specific focused MRI protocols low-field-strength applications, iodine contrast media recycling programs judicious use US-enhancing agents improved radiopharmaceutical procurement waste management cardiology, reusable supplies interventional suites. Finally, future directions research highlighted, life cycle assessments over lifespan artificial intelligence tools.

Язык: Английский

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PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner

Redox Biology, Год журнала: 2024, Номер 72, С. 103158 - 103158

Опубликована: Апрель 12, 2024

Exposure to PM2.5 is correlated with cardiac remodeling, of which hypertrophy one the main clinical manifestations. Ferroptosis plays an important role in hypertrophy. However, potential mechanism PM2.5-induced through ferroptosis remains unclear. This study aimed explore molecular caused by and intervention MitoQ involved this process. The results showed that could induce dysfunction mice. Meanwhile, characteristics were observed, such as iron homeostasis imbalance, lipid peroxidation, mitochondrial damage abnormal expression key molecules. treatment effectively mitigate these alternations. After treating human cardiomyocyte AC16 PM2.5, activator (Erastin) inhibitor (Fer-1), it was found promote ferritinophagy lead well accumulation intracellular labile iron. Subsequently, mitophagy activated provided additional source iron, enhancing sensitivity cells ferroptosis. Furthermore, Fer-1 alleviated cytotoxicity overload cytoplasm mitochondria cells. It worth noting during process ferroptosis, metabolism mediated activation a temporal order. In addition, NCOA4 knockdown reversed imbalance peroxidation thereby alleviating summary, our imbalance-mediated crosstalk played

Язык: Английский

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Heat and Cardiovascular Mortality: An Epidemiological Perspective

Circulation Research, Год журнала: 2024, Номер 134(9), С. 1098 - 1112

Опубликована: Апрель 25, 2024

As global temperatures rise, extreme heat events are projected to become more frequent and intense. Extreme causes a wide range of health effects, including an overall increase in morbidity mortality. It is important note that while there sufficient epidemiological evidence for heat-related increases all-cause mortality, on the association between cause-specific deaths such as cardiovascular disease (CVD) mortality (and its specific causes) limited, with inconsistent findings. Existing systematic reviews meta-analyses studies CVD have summarized available evidence. However, target audience mainly limited field environmental epidemiology. This overarching perspective aims provide professionals comprehensive overview recent how associated The rationale behind this broad better understanding effect will help optimize their plans adapt changes brought about by climate change events. To policymakers, would formulate targeted mitigation, strengthen early warning systems, develop adaptation strategies. Despite heterogeneity worldwide, due part different climatic conditions population dynamics, clear link risk has often been found be higher vulnerable subgroups, older people, people preexisting conditions, socioeconomically deprived. also highlights lack from low- middle-income countries focuses deaths. In addition, temporal well interactive other factors potential biological pathways. Importantly, these various aspects never fully investigated and, therefore, true extent impact remains largely unknown. Furthermore, research gaps solutions generate robust future consequences

Язык: Английский

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Society for Cardiovascular Magnetic Resonance recommendations toward environmentally sustainable cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance, Год журнала: 2025, Номер unknown, С. 101840 - 101840

Опубликована: Янв. 1, 2025

Язык: Английский

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Ozone, Heat Wave, and Cardiovascular Disease Mortality: A Population-Based Case-Crossover Study

Environmental Science & Technology, Год журнала: 2023, Номер 58(1), С. 171 - 181

Опубликована: Дек. 15, 2023

A case-crossover study among 511,767 cardiovascular disease (CVD) deaths in Jiangsu province, China, during 2015–2021 was conducted to assess the association of exposure ambient ozone (O3) and heat wave with CVD mortality explore their possible interactions. Heat defined as extreme high temperature for at least two consecutive days. Grid-level waves were by multiple combinations apparent thresholds durations. Residential O3 exposures assessed using grid data sets (spatial resolution: 1 km × O3; 0.0625° wave). Conditional logistic regression models applied exposure–response analyses evaluation additive Under different definitions, odds ratios (ORs) associated medium-level high-level ranged from 1.029 1.107 compared low-level O3, while ORs 1.14 1.65. Significant synergistic effects on observed exposures, which generally greater higher levels exposure, thresholds, longer durations exposure. Up 5.8% attributable wave. Women older adults more vulnerable Exposure both significantly an increased mortality, can interact synergistically trigger deaths.

Язык: Английский

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Heat wave, fine particulate matter, and cardiovascular disease mortality: A time-stratified case-crossover study in Shenzhen, China

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117944 - 117944

Опубликована: Март 1, 2025

In the context of global warming, frequency heat wave and concentration fine particulate matter (PM2.5) have increased, more people are co-exposed to air pollution extreme heat. However, interaction between PM2.5 on cardiovascular disease (CVD) mortality remained largely unknown. We conducted a time-stratified case-crossover study 40,169 CVD deaths in Shenzhen, China 2013 2022. Meteorological data pollutants information were obtained based residential addresses from validated grid datasets. A total 21 definitions constructed using various relative temperature thresholds durations. Conditional logistic regression was used evaluate independent interactive effects exposure mortality. The odds ratios (ORs) 95 % confidence intervals (CIs) for associated with waves ranged 1.17 (95 CI: 1.001,1.36) 1.91 1.42, 2.56). For every increase 10 µg/m³ exposure, ORs CI) 1.0283 1.0162, 1.0406) 1.029 1.0169, 1.0413). There synergistic effect exposures It estimated that up 2.03 attributable levels exceeding interim target 4 World Health Organization quality guidelines (≥ 25 μg/m3), resulting 816 premature deaths. Females individuals over 75 years old vulnerable populations. Heat individually synergistically contributed increased risks Our findings indicate reducing both may yield significant health benefits prevent portion CVDs.

Язык: Английский

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Nonlinear Relation Between Cardiac Mortality and Excess Temperature in Heatwaves

Journal of the American College of Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Effects of increased temperature on atmospheric pollutant levels and human health in small and medium-sized cities in southern Brazil

Case Studies in Chemical and Environmental Engineering, Год журнала: 2025, Номер 11, С. 101170 - 101170

Опубликована: Фев. 26, 2025

Язык: Английский

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Effects and interaction of humidex and air pollution on influenza: A national analysis of 319 cities in mainland China

Journal of Hazardous Materials, Год журнала: 2025, Номер 490, С. 137865 - 137865

Опубликована: Март 6, 2025

Язык: Английский

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