Spexin inhibits excessive autophagy‐induced ferroptosis to alleviate doxorubicin‐induced cardiotoxicity by upregulating Beclin 1
Wen Ou,
Haiqiong Liu,
Changhai Chen
и другие.
British Journal of Pharmacology,
Год журнала:
2024,
Номер
181(21), С. 4195 - 4213
Опубликована: Июль 3, 2024
Doxorubicin
is
widely
used
in
the
treatment
of
malignant
tumours,
but
doxorubicin-induced
cardiotoxicity
severely
limits
its
clinical
application.
Spexin
a
neuropeptide
that
acts
as
novel
biomarker
cardiovascular
disease.
However,
effects
spexin
on
unclear.
Язык: Английский
Spexin (Neuropeptide Q): Distribution, Functional Roles, and Emerging Therapeutic Perspectives
International Journal of Peptide Research and Therapeutics,
Год журнала:
2025,
Номер
31(2)
Опубликована: Янв. 8, 2025
Язык: Английский
Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects
Bone Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Фев. 25, 2025
Abstract
The
muscular
system
plays
a
critical
role
in
the
human
body
by
governing
skeletal
movement,
cardiovascular
function,
and
activities
of
digestive
organs.
Additionally,
muscle
tissues
serve
an
endocrine
function
secreting
myogenic
cytokines,
thereby
regulating
metabolism
throughout
entire
body.
Maintaining
requires
iron
homeostasis.
Recent
studies
suggest
that
disruptions
ferroptosis,
form
iron-dependent
cell
death,
are
essential
contributors
to
progression
wide
range
diseases
disorders,
including
sarcopenia,
cardiomyopathy,
amyotrophic
lateral
sclerosis.
Thus,
comprehensive
overview
mechanisms
ferroptosis
these
conditions
is
crucial
for
identifying
potential
therapeutic
targets
developing
new
strategies
disease
treatment
and/or
prevention.
This
review
aims
summarize
recent
advances
understanding
molecular
underlying
context
injury,
as
well
associated
disorders.
Moreover,
we
discuss
within
pathway
possible
managing
Finally,
shed
light
on
current
limitations
future
prospects
interventions
targeting
ferroptosis.
Язык: Английский
Inflammation pathways as therapeutic targets in angiotensin II induced atrial fibrillation
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 3, 2025
Atrial
fibrillation
(AF),
a
common
cardiac
arrhythmia,
is
associated
with
severe
complications
such
as
stroke
and
heart
failure.
Although
the
precise
mechanisms
underlying
AF
remain
elusive,
inflammation
acknowledged
pivotal
factor
in
its
progression.
Angiotensin
II
(AngII)
implicated
promoting
atrial
remodeling
inflammation.
However,
exact
pathways
through
which
AngII
exacerbates
are
still
not
fully
defined.
This
study
explores
key
molecular
involved,
including
dysregulation
of
calcium
ions,
altered
connexin
expression,
activation
signaling
TGF-β,
PI3K/AKT,
MAPK,
NF-κB/NLRP3,
Rac1/JAK/STAT3.
These
instrumental
contributing
to
fibrosis,
electrical
remodeling,
increased
susceptibility
AF.
Ang
II-induced
disrupts
ion
channel
function,
resulting
structural
atria
significantly
elevating
risk
Anti-inflammatory
treatments
RAAS
inhibitors,
colchicine,
statins
have
demonstrated
potential
reducing
incidence
AF,
although
clinical
outcomes
inconsistent.
manuscript
underscores
link
between
AngII-induced
development
proposing
importance
targeting
management
Язык: Английский
Novel hypothalamic pathways for metabolic effects of spexin
Pharmacological Research,
Год журнала:
2024,
Номер
208, С. 107399 - 107399
Опубликована: Сен. 7, 2024
One
of
the
main
underlying
etiologies
type
2
diabetes
(T2DM)
is
insulin
resistance,
which
most
frequently
caused
by
obesity.
Notably,
deregulation
adipokine
secretion
from
visceral
adiposity
has
been
identified
as
a
crucial
characteristic
and
Spexin
an
that
released
many
different
tissues,
including
white
adipocytes
glandular
stomach,
negatively
connected
with
state
energy
storage.
This
peptide
acts
through
GALR2/3
receptors
to
control
wide
range
metabolic
processes,
inflammation,
browning,
lipolysis,
expenditure,
eating
behavior.
Specifically,
spexin
can
enter
hypothalamus
regulate
hypothalamic
melanocortin
system,
in
turn
balances
expenditure
food
intake.
review
examines
recent
advances
mechanisms
obesity
T2DM.
In
particular,
we
address
topics
basic
research
clinical
findings,
such
analysis
possible
function
response,
involves
reducing
intake
increasing
while
also
enhancing
sensitivity
glucose
tolerance.
Gaining
more
insight
into
underlie
system's
over
metabolism
homeostasis
may
facilitate
development
innovative
treatment
approaches
focus
on
combating
diabetes.
Язык: Английский
Spexin Hormone Signaling and Atrial Fibrillation: The Knowns and Unknowns
Circulation,
Год журнала:
2024,
Номер
150(2), С. 128 - 131
Опубликована: Июль 8, 2024
Язык: Английский
Identification of the optimal reference genes for atrial fibrillation model established by iPSC-derived atrial myocytes
BMC Genomics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Окт. 25, 2024
Atrial
fibrillation
(AF)
stands
as
a
prevalent
and
detrimental
arrhythmic
disorder,
characterized
by
intricate
pathophysiological
mechanisms.
The
availability
of
reliable
reproducible
AF
models
is
pivotal
in
unraveling
the
underlying
mechanisms
this
complex
condition.
Unfortunately,
researchers
are
still
confronted
with
absence
consistent
vitro
models,
hindering
progress
crucial
area
research.
Human
induced
pluripotent
stem
cells
derived
atrial
myocytes
(hiPSC-AMs)
were
generated
based
on
GiWi
methods
verified
whole-cell
patch
clamp,
immunofluorescent
staining,
flow
cytometry.
Then
hiPSC-AMs
employed
to
establish
model
HS.
Whole-cell
clamp
technique
calcium
imaging
used
identify
model.
stability
29
reference
genes
was
evaluated
using
delta-Ct,
GeNorm,
NormFinder,
BestKeeper
algorithms;
HiPSC-AMs
displayed
myocyte
action
potentials
expressed
atrial-specific
protein
MLC-2
A
NR2F2,
about
70%
cardiomyocytes
positive.
After
HS,
showed
significant
increase
beating
frequency,
shortened
potential
duration,
increased
transient
frequency.
Of
candidate
genes,
top
five
most
stably
ranked
ABL1,
RPL37A,
POP4,
RPL30,
EIF2B1.
normalization
KCNJ2
significantly
upregulated
model;
Conclusions:
In
established
ABL1
provides
greater
efficiency
than
commonly
GAPDH.
Язык: Английский