The association of triglyceride-glucose index and combined obesity indicators with chest pain and risk of cardiovascular disease in American population with pre-diabetes or diabetes

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Сен. 6, 2024

To investigate the correlation of triglyceride-glucose (TyG) index and its combined obesity indicators with chest pain cardiovascular disease (CVD) in pre-diabetes diabetes population.

Язык: Английский

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Oxidative stress mediates the association between triglyceride-glucose index and risk of cardiovascular and all-cause mortality in metabolic syndrome: evidence from a prospective cohort study

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Авг. 20, 2024

Background The aim of this study was to investigate the relationship between triglyceride-glucose (TyG) index and cardiovascular disease (CVD) all-cause mortality in adults with metabolic syndrome (MeS) explore mediating role oxidative stress. Methods This included 6131 MeS from National Health Nutrition Examination Survey (NHANES). relationships TyG were elucidated using multivariate Cox proportional hazards models, restricted cubic splines (RCS) Fine-Gray competing risk model. In addition, mediation analysis used test indirect effect stress indicators. Results Over a median 106-month follow-up, total 357 CVD 1292 deaths recorded. After adjustment, there J-type mortality, optimal inflection point 9.13 8.92. threshold point, positively associated (HR: 4.21, 95%CI: 1.82, 9.78) mortality(HR: 2.93, 2.05, 4.18). Even non-cardiovascular as competitive risk, model also illustrated that cumulative incidence higher >9.13 (Fine-Gray P< 0.01). Mediation revealed biomarkers stress, including gamma-glutamyl transferase uric acid, collectively mediated 10.53% association 8.44% (P < 0.05). Conclusion cohort study, found have J-shaped population may play key relationship.

Язык: Английский

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Analyzing the impact of glycemic metabolic status on cardiovascular mortality and all-cause mortality related to the estimated glucose disposal rate: a nationwide cohort study

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 21, 2025

Objective The Estimated Glucose Disposal Rate (eGDR) serves as a surrogate marker for insulin resistance, with numerous studies highlighting its significant prognostic value. This paper aims to analyze the impact of eGDR on cardiovascular and all-cause mortality across different glycemic metabolic statuses, including normal fasting glucose (NFG), prediabetes, diabetes. Methods study included 46,016 American adults who underwent health examinations part National Health Nutrition Examination Survey from 1999 2018. Multivariable Cox regression was employed explore relationships between rates under varying states. Additionally, Kaplan-Meier curves were used compare cumulative incidence statuses. Finally, predictive value assessed using receiver operating characteristic curves. Results During an average follow-up 115 months, total 6,906 (15.01%) participants experienced mortality, 1,798 (3.91%) deaths attributed causes. analysis revealed that higher levels associated gradually reduced rates. After adjusting confounders, elevated protective against both mortality; effect notably stronger [Cardiovascular hazard ratio: 0.92; All-cause 0.94]. Further interaction tests indicated status significantly modified ( P -interaction<0.0001); specifically, high conferred protection in individuals NFG prediabetes compared those Receiver suggested had superior prediabetic populations diabetic group. Conclusion is straightforward acting factor adults, modifying this effect. Specifically, offer diabetes; moreover, appears be more suitable predicting events populations.

Язык: Английский

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Association between weight-adjusted waist index with incident stroke in the elderly with hypertension: a cohort study

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 27, 2024

The objective of this study was to ascertain the relationship between weight-adjusted waist index (WWI) and risk stroke in an elderly hypertensive population, a that has not been previously elucidated. Cox regression model employed assess correlation baseline WWI measurements incidence stroke. To further elucidate shape association stroke, restricted cubic splines were employed. Furthermore, subgroup analyses interaction tests carried out investigate potential heterogeneities. Our cohort comprised 4962 individuals aged 60 years or older with no prior history Over median follow-up 3.2 years, we found 547 new-onset cases. After adjusting for confounding variables, analysis revealed positive hazard ratios (HRs) escalating progressively as values increased. When compared lowest quartile WWI, highest demonstrated HR 1.87 (95% CI, 1.44–2.42) Subgroup confirmed consistency across different demographic clinical strata. findings indicate elevated is significantly related higher among patients hypertension. These results underscore importance stratification tool. confirm these explore causal mechanisms behind observed correlation, more necessary.

Язык: Английский

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Increased prevalence of cardiovascular-kidney-metabolic syndrome conditions during COVID-19: A propensity score-matched study

Diabetes Research and Clinical Practice, Год журнала: 2024, Номер 218, С. 111926 - 111926

Опубликована: Ноя. 12, 2024

Язык: Английский

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Clinical predictive model of new-onset atrial fibrillation in patients with acute myocardial infarction after percutaneous coronary intervention

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

New-onset atrial fibrillation (NOAF) is associated with increased morbidity and mortality. Despite identifying numerous factors contributing to NOAF, the underlying mechanisms remain uncertain. This study introduces triglyceride-glucose index (TyG index) as a predictive indicator establishes clinical model. We included 551 patients acute myocardial infarction (AMI) without history of (AF). These were divided into two groups based on occurrence postoperative NOAF during hospitalization: group (n = 94) sinus rhythm (SR) 457). utilized regression model analyze risk establish The performance, calibration, effectiveness evaluated using receiver operational characteristics (ROC), calibration curve, decision curve analysis, impact curve. 94 developed hospitalization. TyG was identified an independent predictor significantly higher in group. Left (LA) diameter, age, systemic inflammatory response (SIRI), creatinine also for NOAF. Combining these build prediction resulted area under (AUC) 0.780 (95% CI 0.358–0.888). ROC, demonstrated that performance new nomogram satisfactory. By incorporating model, after AMI hospitalization can be effectively predicted. Early detection improve prognosis patients.

Язык: Английский

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The Role of Stress Hyperglycemia on Delirium Onset

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 407 - 407

Опубликована: Янв. 10, 2025

Delirium is an acute neuropsychiatric syndrome that recognizes one or more underlying causal medical conditions. Stress hyperglycemia usually refers to transient associated with stress conditions such as stroke, myocardial infarction, and major surgery. Both delirium share common pathways, activation of inflammation. has been negative outcomes, recent studies suggested there increased risk onset in patients hyperglycemia. The purpose this review illustrate the relationship between delirium. Initially, we role diabetes on onset, summarize criteria used for diagnosis hyperglycemia, discuss impact outcome, focus evidence about

Язык: Английский

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Association between the triglyceride-glucose index and contrast-induced nephropathy in chronic total occlusion patients undergoing percutaneous coronary intervention

BMC Cardiovascular Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 20, 2025

The triglyceride glucose (TyG) index is a biomarker of insulin resistance and associated with an increased risk cardiovascular events. Contrast-induced nephropathy (CIN) important complication that causes poor outcomes in patients undergoing percutaneous coronary intervention (PCI). In this study, we aimed to investigate the relationship between TyG CIN mortality who underwent PCI due chronic total occlusion (CTO). Two hundred eighteen individuals from three separate medical centers procedural February 2010 April 2012 had CTO lesion at least one artery were recruited. According index, divided into two groups. Patients ≥ 8.65 included Group 1, < 2. followed up for 96 months. main outcome was development mortality. mean age (65.8 ± 10.94 vs. 61.68 11.4, P = 0.009), diabetes mellitus (60 [44.8%] 11 [13.1%], 0.001), dyslipidemia rates (52 [38.8%] 21 [25%], 0.036) higher group 1. multivariable logistic regression analysis, it seen (OR 1.04, 95% CI 1.01–1.08, 0.020), kidney disease 2.34, 1.02–5.33, 0.044), peripheral 5.66, 1.24–25.91, p 0.026), LVEF 0.95, 0.92–0.99, 0.005), LDL cholesterol levels 1.00, 95%CI 1.00–1.02, 0.024) 2.17, 1.21–3.89, 0.009) independent predictors CIN. Our study demonstrates correlation prevalence PCI. Adding routine clinical evaluation may help protect

Язык: Английский

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The prognostic association of triglyceride-glucose index and its derived indicators with stable coronary artery disease patients undergoing percutaneous coronary intervention

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Янв. 22, 2025

Aims Research on the triglyceride-glucose (TyG) index in patients with stable coronary artery disease (SCAD) remains relatively limited. Therefore, this study aims to investigate association of TyG and its derived indicators, including baseline index, triglyceride glucose-body mass (TyG-BMI), mean glucose index-standard deviation (TyG-SD), prognosis SCAD undergoing percutaneous intervention (PCI). Methods This retrospective enrolled 2,306 patients. The Cox proportional hazards model was utilized evaluate between four indicators major adverse cardiovascular cerebrovascular events (MACCE). predictive ability for MACCE assessed using time-dependent receiver operating characteristic (ROC) curve. Kaplan-Meier survival analysis employed assess prognostic differences among groups. Results After a median follow-up 26.1 months, total 352 (15.3%) experienced MACCE. regression revealed that under fully adjusted model, when were stratified by tertiles, highest tertile each indicator had significantly increased risk compared those lowest tertile. Specifically, hazard ratio 1.653 (95% confidence intervals (CI): 1.234-2.214), TyG-BMI 2.467 (95%CI: 1.849-3.293), 2.451 1.794-3.349), TyG-SD 1.896 1.430-2.513). Time-dependent ROC curve demonstrated strongest at time point. results showed grouped there significant cumulative incidence three groups (P &lt; 0.05). Conclusion Higher levels independently positively associated PCI. Among these greatest value Consequently, tracking long-term trends may be prioritized clinical practice.

Язык: Английский

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Triglyceride-glucose index is associated with microcirculatory resistance in patients with type 2 diabetes and STEMI undergoing primary PCI

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 8, 2025

The triglyceride-glucose (TyG) index is emerging as a promising marker for insulin resistance and serves an independent risk predictor cardiovascular outcomes. coronary angiography-derived of microcirculatory (AMR) computed to evaluate microcirculation. However, the association between TyG AMR in patients with type 2 diabetes mellitus (T2DM) ST-segment elevation myocardial infarction (STEMI) remains unclear. We consecutively recruited 168 T2DM STEMI who underwent primary percutaneous intervention (pPCI) at Taizhou People's Hospital from January 2022 December 2023. Patients were classified into low group (AMR < 2.5) high ≥ 2.5). was calculated using formula: ln [plasma triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. study enrolled 81 87 group, being significantly higher group. Multivariable logistic regression analysis revealed significant after adjusting confounding variables (odds ratio: 2.449, 95% confidence interval: 1.421–4.220, p = 0.001). area under curve predicting 0.650 (95% 0.57–0.73, 0.001), cut-off value 9.57. Our findings indicate that associated undergoing pPCI, suggesting it may serve valuable this population.

Язык: Английский

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