Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
142, С. 112041 - 112041
Опубликована: Авг. 16, 2021
Senescence
is
a
crucial
player
in
several
metabolic
disorders
and
chronic
inflammatory
diseases.
Recent
data
prove
the
involvement
of
hepatocyte
senescence
development
NAFLD
(non-alcoholic
fatty
liver
disease).
As
main
energy
ROS
(reactive
oxygen
species)
producing
organelle,
mitochondria
play
central
role
accelerated
diseases
development.
In
this
review,
we
focus
on
regulation
mitochondrial
Ca2+
homeostasis,
NAD+/NADH
ratio,
UPRmt
(mitochondrial
unfolded
protein
response),
phospholipids
acid
oxidation
hepatic
senescence,
lifespan
disease
susceptibility.
Additionally,
nuclear
mutations
lifespan-modulation
discussed.
While
DNA
SNPs
(single
nucleotide
polymorphisms)
can
be
used
as
effective
diagnostic
markers
targets
for
treatments,
advanced
age
should
considered
an
independent
risk
factor
Frontiers in Genetics,
Год журнала:
2021,
Номер
12
Опубликована: Май 21, 2021
Aging
affects
most
living
organisms
and
includes
the
processes
that
reduce
health
survival.
The
chronological
biological
age
of
individuals
can
differ
remarkably,
there
is
a
lack
reliable
biomarkers
to
monitor
consequences
aging.
In
this
review
we
give
an
overview
commonly
mentioned
frequently
used
potential
aging-related
biomarkers.
We
were
interested
in
aging
general
related
cellular
senescence
particular.
To
answer
question
whether
feature
relevant
as
biomarker
or
scientific
community
PICO
strategy
known
from
evidence-based
medicine.
introduced
two
scoring
systems,
aimed
at
reflecting
relevance
measurement
effort,
which
be
support
study
designs
both
clinical
research
settings.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(15), С. 8689 - 8689
Опубликована: Авг. 4, 2022
The
complement
system
is
a
part
of
the
immune
and
consists
multiple
components
with
biological
functions
such
as
defense
against
pathogens
immunomodulation.
has
three
activation
pathways:
classical
pathway,
lectin
alternative
pathway.
Increasing
evidence
indicates
that
plays
role
in
aging.
Complement
inflammatory
processes,
metabolism,
apoptosis,
mitochondrial
function,
Wnt
signaling
pathways.
In
addition,
significant
aging-related
diseases,
including
Alzheimer's
disease,
age-related
macular
degeneration,
osteoarthritis.
However,
effect
on
aging
diseases
still
unclear.
Thus,
better
understanding
potential
relationship
between
complement,
aging,
will
provide
molecular
targets
for
treating
while
focusing
balance
during
treatment.
Inhibition
single
component
does
not
result
good
outcome.
this
review,
we
discussed
research
progress
effects
diseases.
Cell Reports,
Год журнала:
2021,
Номер
35(5), С. 109076 - 109076
Опубликована: Май 1, 2021
We
lack
a
mechanistic
understanding
of
aging-mediated
changes
in
mitochondrial
bioenergetics
and
lipid
metabolism
that
affect
T
cell
function.
The
bioactive
sphingolipid
ceramide,
induced
by
aging
stress,
mediates
mitophagy
death;
however,
the
aging-related
roles
ceramide
regulating
function
remain
unknown.
Here,
we
show
activated
cells
isolated
from
mice
have
elevated
C14/C16
accumulation
mitochondria,
generated
synthase
6,
leading
to
mitophagy/mitochondrial
dysfunction.
Mechanistically,
aging-dependent
inhibits
protein
kinase
A,
cells.
This
aging/ceramide-dependent
attenuates
antitumor
functions
vitro
vivo.
Also,
inhibition
or
PKA
activation
genetic
pharmacologic
means
prevents
restores
central
memory
phenotype
Thus,
these
studies
help
explain
mechanisms
behind
dysregulation
cells'
activity,
which
can
be
restored
inhibiting
ceramide-dependent
mitophagy.
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
142, С. 112041 - 112041
Опубликована: Авг. 16, 2021
Senescence
is
a
crucial
player
in
several
metabolic
disorders
and
chronic
inflammatory
diseases.
Recent
data
prove
the
involvement
of
hepatocyte
senescence
development
NAFLD
(non-alcoholic
fatty
liver
disease).
As
main
energy
ROS
(reactive
oxygen
species)
producing
organelle,
mitochondria
play
central
role
accelerated
diseases
development.
In
this
review,
we
focus
on
regulation
mitochondrial
Ca2+
homeostasis,
NAD+/NADH
ratio,
UPRmt
(mitochondrial
unfolded
protein
response),
phospholipids
acid
oxidation
hepatic
senescence,
lifespan
disease
susceptibility.
Additionally,
nuclear
mutations
lifespan-modulation
discussed.
While
DNA
SNPs
(single
nucleotide
polymorphisms)
can
be
used
as
effective
diagnostic
markers
targets
for
treatments,
advanced
age
should
considered
an
independent
risk
factor
