Embracing variability in the search for biological mechanisms of psychiatric illness

Trends in Cognitive Sciences, Год журнала: 2024, Номер 29(1), С. 85 - 99

Опубликована: Ноя. 6, 2024

Язык: Английский

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Neural interactions in the human frontal cortex dissociate reward and punishment learning

eLife, Год журнала: 2024, Номер 12

Опубликована: Июнь 28, 2024

How human prefrontal and insular regions interact while maximizing rewards minimizing punishments is unknown. Capitalizing on intracranial recordings, we demonstrate that the functional specificity toward reward or punishment learning better disentangled by interactions compared to local representations. Prefrontal cortices display non-selective neural populations punishments. Non-selective responses, however, give rise context-specific interareal interactions. We identify a subsystem with redundant between orbitofrontal ventromedial cortices, driving role of latter. In addition, find dorsolateral insula. Finally, switching mediated synergistic two subsystems. These results provide unifying explanation distributed cortical representations supporting learning.

Язык: Английский

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Neural interactions in the human frontal cortex dissociate reward and punishment learning

eLife, Год журнала: 2023, Номер 12

Опубликована: Ноя. 9, 2023

How human prefrontal and insular regions interact while maximizing rewards minimizing punishments is unknown. Capitalizing on intracranial recordings, we demonstrate that the functional specificity toward reward or punishment learning better disentangled by interactions compared to local representations. Prefrontal cortices display non-selective neural populations punishments. Non-selective responses, however, give rise context-specific interareal interactions. We identify a subsystem with redundant between orbitofrontal ventromedial cortices, driving role of latter. In addition, find dorsolateral insula. Finally, switching mediated synergistic two subsystems. These results provide unifying explanation distributed cortical representations supporting learning.

Язык: Английский

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Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Язык: Английский

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Polyconnectomic scoring of functional connectivity patterns across eight neuropsychiatric and three neurodegenerative disorders

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Can neurotechnology revolutionize cognitive enhancement?

PLoS Biology, Год журнала: 2024, Номер 22(10), С. e3002831 - e3002831

Опубликована: Окт. 29, 2024

The development and implementation of neurotechnology for cognitive enhancement could spearhead a new wave innovation in the information age. However, we argue here that this will only happen with more fundamental understanding human brain function.

Язык: Английский

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Multivariate mapping of brain pathology: a step forward with stumbling blocks

Brain Communications, Год журнала: 2024, Номер 6(5)

Опубликована: Янв. 1, 2024

This scientific commentary refers to 'Ground-truth validation of uni- and multivariate lesion inference approaches', by Zavaglia

Язык: Английский

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Redefining language networks: connectivity beyond localised regions

Brain Structure and Function, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Язык: Английский

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Brain and Behavior: A Pragmatic Approach

Опубликована: Дек. 6, 2024

Abstract In the final chapter, we draw a general conclusion on brain development and law. After summarizing previous results, I make pragmatic proposal for connection between psycho-behavioral neuroscientific knowledge. At end, important open questions expected results neurolaw are described.

Язык: Английский

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The Brain and the Law

Опубликована: Дек. 6, 2024

Abstract After an introduction to the general topics of neurolaw, this chapter will focus in particular on concept criminal responsibility. We see that not causation, but knowledge and conscious control are central this. This corresponds a notion minimal rationality people. These criteria then applied free debate frequently cited cases brain damage nineteenth twenty-first centuries. analysis shows existing psycho-behavioral ideally supplemented by neuroscientific methods, certainly cannot be replaced for time being.

Язык: Английский

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