Combination of Physicochemical Tropism and Affinity Moiety Targeting of Lipid Nanoparticles Enhances Organ Targeting DOI
Marco E. Zamora, Serena Omo‐Lamai, Manthan N. Patel

и другие.

Nano Letters, Год журнала: 2024, Номер unknown

Опубликована: Апрель 10, 2024

Two camps have emerged for targeting nanoparticles to specific organs and cell types: affinity moiety physicochemical tropism. Here we directly compare combine both using intravenous (IV) lipid (LNPs) designed target the lungs. We utilized PECAM antibodies as moieties cationic lipids These methods yield nearly identical lung uptake, but aPECAM LNPs show higher endothelial specificity. combining these had >2-fold uptake than either method alone markedly enhanced epithelial uptake. To determine if is because lungs are first organ downstream of IV injection, compared vs intra-arterial (IA) injection into carotid artery, finding that IA combined-targeting achieve 35% injected dose per gram (%ID/g) in first-pass organ, brain, among highest reported. Thus, strategies provides benefits neither achieves alone.

Язык: Английский

Nanoghosts: Harnessing Mesenchymal Stem Cell Membrane for Construction of Drug Delivery Platforms Via Optimized Biomimetics DOI
Yuan Xiao, Ren‐He Xu, Yunlu Dai

и другие.

Small, Год журнала: 2023, Номер 20(1)

Опубликована: Авг. 31, 2023

Abstract Mesenchymal stem cells (MSCs) are becoming hotspots for application in disease therapies recently, combining with biomaterials and drug delivery system. A major advantage of MSCs applied system is that these enable specific targeting releasing cargos to the sites. However, potential tumor tropic effects raised concerns on biosafety. To solve this problem, there emerging methods isolating cell membranes developing nanoformulations perform delivery, which avoids biosafety without disturbing membrane functions polarizing locating. These cargoes so called “nanoghosts.” This review article summarizes current applications nanoghosts, promising be isolation nanoghost construction, possible approaches develop better harnessing from MSC ghost membranes.

Язык: Английский

Процитировано

17
Cell-derived membrane biomimetic nanocarriers for targeted therapy of pulmonary disease DOI
Xixi Zheng, Tianyuan Zhang, Ting Huang

и другие.

International Journal of Pharmaceutics, Год журнала: 2022, Номер 620, С. 121757 - 121757

Опубликована: Апрель 18, 2022

Язык: Английский

Процитировано

22
Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia DOI
Arun Pradhan,

Lixiao Che,

Vladimir Ustiyan

и другие.

American Journal of Respiratory and Critical Care Medicine, Год журнала: 2022, Номер 207(8), С. 1042 - 1054

Опубликована: Дек. 8, 2022

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is linked to heterozygous mutations in the

Язык: Английский

Процитировано

20
Advanced surgical technologies for lung cancer treatment: Current status and perspectives DOI Creative Commons
Hongfei Cai, Yonghui Wang, Da Qin

и другие.

Engineered Regeneration, Год журнала: 2022, Номер 4(1), С. 55 - 67

Опубликована: Дек. 2, 2022

Lung cancer has become one of the key life-threatening factors and is most common type tumor. With improvement equipment lung awareness, surgical treatment becoming more mature. Surgery can provide an important part individualized strategies for patients with different stages wishes. In addition, concept minimally invasive, precise, intelligent triggered a revolutionary change in strategy cancer. Therefore, this review focuses on development surgery history, summarizing era from traditional to invasive thoracic based TV-assisted surgery. The operating methods effects are comprehensively introduced, optimization future also discussed. Along techniques, there explorations nanotechnology application imaging, combination nanomedicine effective solution today. So, summarizes prospects before, during after

Язык: Английский

Процитировано

20
Combination of Physicochemical Tropism and Affinity Moiety Targeting of Lipid Nanoparticles Enhances Organ Targeting DOI
Marco E. Zamora, Serena Omo‐Lamai, Manthan N. Patel

и другие.

Nano Letters, Год журнала: 2024, Номер unknown

Опубликована: Апрель 10, 2024

Two camps have emerged for targeting nanoparticles to specific organs and cell types: affinity moiety physicochemical tropism. Here we directly compare combine both using intravenous (IV) lipid (LNPs) designed target the lungs. We utilized PECAM antibodies as moieties cationic lipids These methods yield nearly identical lung uptake, but aPECAM LNPs show higher endothelial specificity. combining these had >2-fold uptake than either method alone markedly enhanced epithelial uptake. To determine if is because lungs are first organ downstream of IV injection, compared vs intra-arterial (IA) injection into carotid artery, finding that IA combined-targeting achieve 35% injected dose per gram (%ID/g) in first-pass organ, brain, among highest reported. Thus, strategies provides benefits neither achieves alone.

Язык: Английский

Процитировано

5