Experimental Eye Research, Год журнала: 2024, Номер 250, С. 110159 - 110159
Опубликована: Ноя. 20, 2024
Язык: Английский
Biogerontology, Год журнала: 2025, Номер 26(2)
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117092 - 117092
Опубликована: Июль 7, 2024
Sepsis-associated encephalopathy (SAE) is a disease characterized by neuroinflammation and cognitive dysfunction caused systemic infection. Inflammation-induced microglial activation closely associated with in SAE. It widely understood that melatonin has strong anti-inflammatory immunomodulatory properties beneficial for sepsis-related brain damage. However, the mechanism of action SAE not been fully elucidated.
Язык: Английский
Процитировано
6
Seminars in Cancer Biology, Год журнала: 2024, Номер 104-105, С. 46 - 60
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
6
Pharmacological Research, Год журнала: 2024, Номер 205, С. 107253 - 107253
Опубликована: Июнь 9, 2024
Melatonin, a versatile hormone produced by the pineal gland, has garnered considerable scientific interest due to its diverse functions. In eye, melatonin regulates variety of key processes like inhibiting angiogenesis reducing vascular endothelial growth factor levels and protecting blood-retinal barrier (BRB) integrity enhancing tight junction proteins pericyte coverage. Melatonin also maintains cell health modulating autophagy via Sirt1/mTOR pathways, reduces inflammation, promotes antioxidant enzyme activity, intraocular pressure fluctuations. Additionally, protects retinal ganglion cells aging inflammatory pathways. Understanding melatonin's multifaceted functions in ocular could expand knowledge pathogenesis, shed new light on therapeutic approaches diseases. this review, we summarize current evidence potential describe roles angiogenesis, BRB maintenance, modulation various eye diseases, which leads conclusion that holds promising treatment for wide range conditions.
Язык: Английский
Процитировано
4
Current Eye Research, Год журнала: 2025, Номер unknown, С. 1 - 11
Опубликована: Янв. 15, 2025
Purpose Chronic inflammation plays an important role in the pathogenesis of choroidal neovascularization (CNV). This study aimed to investigate effect CHF5074, a γ-secretase inhibitor, on angiogenesis laser-induced CNV model and elucidate its possible molecular mechanism.
Язык: Английский
Процитировано
0
Chronobiology International, Год журнала: 2025, Номер unknown, С. 1 - 15
Опубликована: Фев. 7, 2025
The eye is an immune-protected organ, which driven by factors such as cytokines, chemicals, light, and mechanical stimuli. circadian clock intrinsic timing mechanism that influences the immune activities, cell count activity, well inflammatory responses. Recent studies have demonstrated also possesses rhythm, this rhythmic regulation participates in ocular modulation. In review, we discuss immunoregulatory mechanisms of within eye, reveal new perspectives for prevention treatment diseases.
Язык: Английский
Процитировано
0
Survey of Ophthalmology, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Апрель 22, 2024
Introduction Age-related macular degeneration (AMD) is a prevalent, chronic and progressive retinal degenerative disease characterized by an inflammatory response mediated activated microglia accumulating in the retina. In this study, we demonstrate therapeutically effects underlying mechanisms of microglial repopulation laser-induced choroidal neovascularization (CNV) model exudative AMD. Methods The CSF1R inhibitor PLX3397 was used to establish treatment paradigm for Neovascular leakage neovascular area were examined fundus fluorescein angiography (FFA) immunostaining whole-mount RPE-choroid-sclera complexes CNV mice receiving PLX3397. Altered cellular senescence measured beta-galactosidase (SA-β-gal) activity p16INK4a expression. effect repopulated on leukocyte infiltration lesions analyzed. Results We showed that ten days followed 11 drug withdrawal sufficient stimulate rapid retina with new microglia. Microglial attenuated pathological choroid dampened lesions. Repopulating exhibited lower levels activation markers, enhanced phagocytic function produced fewer cytokines involved immune response, thereby ameliorating attenuating Discussion described herein are therefore promising strategy restricting inflammation neovascularization, which important players pathophysiology
Язык: Английский
Процитировано
3
Investigative Ophthalmology & Visual Science, Год журнала: 2024, Номер 65(6), С. 34 - 34
Опубликована: Июнь 24, 2024
Purpose: The aim of this study was to elucidate the role Sema4D in pathogenesis senescence-associated choroidal neovascularization (CNV) and explore its underlying mechanisms. Methods: In study, we utilized a model laser-induced CNV both young (3 months old) old (18 mice, including those with or without knockout. expression localization were assessed using PCR, Western blot, immunostaining. Subsequently, morphological imaging examinations used evaluate size vascular leakage. Finally, M2 markers, senescence-related molecules involved RhoA/ROCK pathway detected. Results: We found that predominantly expressed macrophages within lesions, mRNA protein levels progressively increased following laser photocoagulation, trend more pronounced mice. Moreover, knockout markedly inhibited polarization senescent reduced leakage CNV, particularly aged Mechanistically, aging upregulate signaling, effectively suppressed activation pathway, significant effects observed Conclusions: Our findings revealed deletion macrophage through suppression ultimately leading attenuation CNV. These data indicate targeting could offer promising approach for gene editing therapy patients neovascular age-related macular degeneration.
Язык: Английский
Процитировано
2
Biomedicines, Год журнала: 2024, Номер 12(4), С. 817 - 817
Опубликована: Апрель 8, 2024
Acknowledged as a significant pathogenetic driver for numerous diseases, aging has become focal point in addressing the profound changes associated with increasing human life expectancy, posing critical concern global public health. Emerging evidence suggests that factors influencing vascular extend their impact to choroidal and retinal blood vessels. The objective of this work is provide comprehensive overview on ocular vessels related diseases. Additionally, study aims illuminate molecular insights contributing cell aging, particular emphasis choroid retina. Moreover, innovative targets operating within domain are presented discussed.
Язык: Английский
Процитировано
1