Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 13, 2025

Osteoarthritis is a degenerative joint disorder characterized by cartilage degradation, synovial inflammation, and altered subchondral bone structure. Recent insights have identified mitochondrial dysfunction as pivotal factor in OA pathogenesis, contributing to chondrocyte apoptosis, oxidative stress, extracellular matrix degradation. Disruptions dynamics, including impaired biogenesis, mitophagy, metabolic shifts from phosphorylation glycolysis, exacerbate damage promoting the production of reactive oxygen species matrix-degrading enzymes such ADAMTS MMPs. This review explores molecular mechanisms underlying OA, emphasizing its role homeostasis inflammation. Furthermore, it highlights emerging therapeutic strategies targeting pathways, antioxidants, mitophagy enhancers, modulators, potential interventions mitigate disease progression, which offer promising avenues for advancing personalized disease-modifying treatments OA.

Язык: Английский

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Genetic mutation in HSF4 is associated with retinal degeneration in mice

Experimental Eye Research, Год журнала: 2025, Номер unknown, С. 110316 - 110316

Опубликована: Фев. 1, 2025

Язык: Английский

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SIRT3 mitigates dry eye disease through the activation of autophagy by deacetylation of FOXO1.

Experimental Eye Research, Год журнала: 2025, Номер unknown, С. 110328 - 110328

Опубликована: Март 1, 2025

Язык: Английский

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[1H-13C]-NMR-Based Metabolic Kinetics Reveals Brain Neurochemical Alterations in Mice After Retinal Ischemia–Reperfusion Injury

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Язык: Английский

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