Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Osteoarthritis is a degenerative joint disorder characterized by cartilage degradation, synovial inflammation, and altered subchondral bone structure. Recent insights have identified mitochondrial dysfunction as pivotal factor in OA pathogenesis, contributing to chondrocyte apoptosis, oxidative stress, extracellular matrix degradation. Disruptions dynamics, including impaired biogenesis, mitophagy, metabolic shifts from phosphorylation glycolysis, exacerbate damage promoting the production of reactive oxygen species matrix-degrading enzymes such ADAMTS MMPs. This review explores molecular mechanisms underlying OA, emphasizing its role homeostasis inflammation. Furthermore, it highlights emerging therapeutic strategies targeting pathways, antioxidants, mitophagy enhancers, modulators, potential interventions mitigate disease progression, which offer promising avenues for advancing personalized disease-modifying treatments OA.

Language: Английский

---

Genetic mutation in HSF4 is associated with retinal degeneration in mice

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110316 - 110316

Published: Feb. 1, 2025

Language: Английский

---

SIRT3 mitigates dry eye disease through the activation of autophagy by deacetylation of FOXO1.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110328 - 110328

Published: March 1, 2025

Language: Английский

---

[1H-13C]-NMR-Based Metabolic Kinetics Reveals Brain Neurochemical Alterations in Mice After Retinal Ischemia–Reperfusion Injury

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

---