Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189231 - 189231
Опубликована: Ноя. 1, 2024
Язык: Английский
Nature Immunology, Год журнала: 2025, Номер 26(1), С. 17 - 28
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
Biomarker Research, Год журнала: 2025, Номер 13(1)
Опубликована: Янв. 23, 2025
Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.
Язык: Английский
Процитировано
3
MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Март 1, 2025
Colorectal cancer (CRC) ranks among the most prevalent malignant neoplasms globally. A growing body of evidence underscores pivotal roles genetic alterations and dysregulated epigenetic modifications in pathogenesis CRC. In recent years, reprogramming tumor cell metabolism has been increasingly acknowledged as a hallmark cancer. Substantial suggests crosstalk between metabolic modifications, highlighting complex interplay genome that warrants further investigation. Biomarkers associated with characteristics CRC hold significant clinical implications. Nevertheless, elucidating genetic, epigenetic, landscapes continues to pose considerable challenges. Here, we attempt summarize key genes driving onset progression related regulators, clarify gene expression signaling pathways regulation, explore potential events reprogramming, providing comprehensive mechanistic explanation for Finally, by integrating reliable targets from genetics, epigenetics, processes promise translation into practice, aim offer more strategies overcome bottlenecks treatment.
Язык: Английский
Процитировано
3
MedComm, Год журнала: 2024, Номер 5(8)
Опубликована: Июль 15, 2024
Neutrophil extracellular traps (NETs), which consist of chromatin DNA studded with granule proteins, are released by neutrophils in response to both infectious and sterile inflammation. Beyond the canonical role defense against pathogens, extrusion NETs also contributes initiation, metastasis, therapeutic malignant diseases. Recently, have been implicated development responses various types tumors. Although extensive work regarding inflammation tumors has reported, a comprehensive summary how these web-like structures initiate propagate tumor progression under specific microenvironment is lacking. In this review, we demonstrate initiators related signaling pathways that trigger formation cancers. Additionally, review will outline current molecular mechanisms regulatory networks during dormant cancer cells awakening, circulating (CTCs) extravasation, metastatic recurrence cancer. This followed perspective on potential clinical as targets treatment local disease, including improvement efficacy existing therapies.
Язык: Английский
Процитировано
13
Trends in cancer, Год журнала: 2024, Номер 10(7), С. 655 - 667
Опубликована: Апрель 24, 2024
Neutrophils, major regulators of innate immunity, have recently emerged as key components the tumor microenvironment. The role neutrophils in cancer has been linked to their ability form neutrophil extracellular traps (NETs), structures composed decondensed DNA decorated with enzymes that are released into space. Here, we discuss pivotal roles NETs influencing responses anticancer therapies such chemotherapy, radiotherapy, immunotherapy, and targeted therapy. Highlighting recent insights, delve dual nature context treatments, examining potential either counteract or enhance treatment outcomes. Strategic targeting may be a promising avenue for crafting combination resistance treatments' efficacy.
Язык: Английский
Процитировано
10
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 21, 2024
Abnormalities in ether lipid metabolism as well the formation of neutrophil extracellular traps have recently been recognized detrimental factors affecting tumorigenesis and progression. However, role abnormal colorectal cancer (CRC) evolution has not reported. Here we show that metabolism-related gene enoyl-CoA δ-isomerase 2 (ECI2) plays a tumor-suppressor CRC is negatively associated with poor prognosis patients. We mechanistically demonstrate ECI2 reduces lipid-mediated Interleukin 8 (IL-8) expression leading to decreased recruitment for suppression. In particular, inhibits production cells by inhibiting peroxisomal localization alkylglycerone phosphate synthase (AGPS), rate-limiting enzyme synthesis. These findings only deepen our understanding metabolic reprogramming interactions progression CRC, but also provide ideas identifying potential diagnostic markers therapeutic targets CRC. The association between rewiring tumour microenvironment shown be relevant Here, authors ether-lipid generation
Язык: Английский
Процитировано
10
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Март 6, 2025
Cancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid with immunosuppressive properties a critical role anti-cancer immune regulation. Cells of different origin, such as associated macrophages (TAMs), neutrophils (TANs), derived suppressor (also called MDSCs) eosinophils are often expanded cancer patients significantly influence survival, but also the outcome therapies. For this reason, variety preclinical clinical studies modulate activity these have been conducted, however without successful date. In review, pro-tumor cells, cell-specific therapeutic targets, vivo on cell re-polarization impact immunotherapies/genetic engineering addressed. This paper summarizes ongoing trials concept chimeric antigen receptor macrophage (CAR-M) therapies, suggests future research perspectives, offering new opportunities development novel treatment strategies.
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118014 - 118014
Опубликована: Март 31, 2025
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 10, 2025
Tumor metabolic reprogramming is a highly complex process that enables tumor survival in the presence of limited nutrients, involving multiple signaling pathways, non-coding RNAs (ncRNAs), and transcription factors. Lately, glutamine has been found to enhance growth, spread, drug resistance cancer cells, while also fostering an immunosuppressive microenvironment aids development. However, some tumors, such as pancreatic melanoma, additional can inhibit proliferation this mechanism closely related regulation immune microenvironment. Therefore, further exploration metabolism tumors essential for understanding pathogenesis developing new metabolically targeted therapies. We systematically review latest research on its role system regulation. Additionally, we clinical progress therapies their application combination with current anti-tumor treatments. Ultimately, address challenges prospects involved anti-cancer strategies aimed at metabolism.
Язык: Английский
Процитировано
1
Journal of Clinical Investigation, Год журнала: 2024, Номер 134(5)
Опубликована: Фев. 29, 2024
Chemotherapy, which primarily acts on cancer cells, can influence the tumor microenvironment and recruitment behavior of stromal cells. In this issue JCI, Li et al. explored potent anticancer effect combination a glutaminase inhibitor (CB-839) 5-FU against PIK3CA-mutant colorectal tumors. This chemotherapy treatment strongly induced neutrophils that formed neutrophil extracellular traps in cancer, actively killed cells by inducing apoptosis. study substantially advances our understanding multifaceted role NETs outcome treatment.
Язык: Английский
Процитировано
5