Imaging and Therapy of Tumors Based on Neutrophil Extracellular Traps DOI Creative Commons
Yongwei Hao,

Dalin Liu,

Kaiyuan Wang

et al.

Small Science, Journal Year: 2024, Volume and Issue: unknown

Published: June 21, 2024

Neutrophil extracellular traps (NETs) formed by neutrophils are netlike scaffolds that mainly contain DNA and a variety of granule proteins. Many stimuli can lead to the NET formation through independent molecular pathways. Clinically, abundance NETs is correlated with poor tumor prognosis. The biological actions complex diverse, including promoting progression, awakening dormant cancer cells, resulting in immunosuppression support growth metastasis. Therefore, NET‐associated pathological processes provide an important clue for both diagnostic imaging alternative therapies many kinds cancers. In recent years, scientists’ efforts have focused on developing novel probes visualize therapeutic strategies degrading or inhibiting its block their pro‐tumoral functions. this review, development evaluation NETs‐targeted intervention progress therapy on.

Language: Английский

The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting DOI
Evgeniy Eruslanov, Yulia Nefedova, Dmitry I. Gabrilovich

et al.

Nature Immunology, Journal Year: 2025, Volume and Issue: 26(1), P. 17 - 28

Published: Jan. 1, 2025

Language: Английский

Citations

2
Neutrophil extracellular traps in cancer DOI Creative Commons
Yuxi Ma, Jielin Wei, Wenshan He

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 15, 2024

Neutrophil extracellular traps (NETs), which consist of chromatin DNA studded with granule proteins, are released by neutrophils in response to both infectious and sterile inflammation. Beyond the canonical role defense against pathogens, extrusion NETs also contributes initiation, metastasis, therapeutic malignant diseases. Recently, have been implicated development responses various types tumors. Although extensive work regarding inflammation tumors has reported, a comprehensive summary how these web-like structures initiate propagate tumor progression under specific microenvironment is lacking. In this review, we demonstrate initiators related signaling pathways that trigger formation cancers. Additionally, review will outline current molecular mechanisms regulatory networks during dormant cancer cells awakening, circulating (CTCs) extravasation, metastatic recurrence cancer. This followed perspective on potential clinical as targets treatment local disease, including improvement efficacy existing therapies.

Language: Английский

Citations

10
The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression DOI Creative Commons
Lixia Chen,

Peiling Dai,

Lei Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 21, 2024

Abnormalities in ether lipid metabolism as well the formation of neutrophil extracellular traps have recently been recognized detrimental factors affecting tumorigenesis and progression. However, role abnormal colorectal cancer (CRC) evolution has not reported. Here we show that metabolism-related gene enoyl-CoA δ-isomerase 2 (ECI2) plays a tumor-suppressor CRC is negatively associated with poor prognosis patients. We mechanistically demonstrate ECI2 reduces lipid-mediated Interleukin 8 (IL-8) expression leading to decreased recruitment for suppression. In particular, inhibits production cells by inhibiting peroxisomal localization alkylglycerone phosphate synthase (AGPS), rate-limiting enzyme synthesis. These findings only deepen our understanding metabolic reprogramming interactions progression CRC, but also provide ideas identifying potential diagnostic markers therapeutic targets CRC. The association between rewiring tumour microenvironment shown be relevant Here, authors ether-lipid generation

Language: Английский

Citations

10
Neutrophil extracellular traps in tumor metabolism and microenvironment DOI Creative Commons

Z. Liu,

Yuanyao Dou, Conghua Lu

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 23, 2025

Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.

Language: Английский

Citations

1
NETscape or NEThance: tailoring anti-cancer therapy DOI Creative Commons
Alexandra Mousset,

Lola Bellone,

Cédric Gaggioli

et al.

Trends in cancer, Journal Year: 2024, Volume and Issue: 10(7), P. 655 - 667

Published: April 24, 2024

Neutrophils, major regulators of innate immunity, have recently emerged as key components the tumor microenvironment. The role neutrophils in cancer has been linked to their ability form neutrophil extracellular traps (NETs), structures composed decondensed DNA decorated with enzymes that are released into space. Here, we discuss pivotal roles NETs influencing responses anticancer therapies such chemotherapy, radiotherapy, immunotherapy, and targeted therapy. Highlighting recent insights, delve dual nature context treatments, examining potential either counteract or enhance treatment outcomes. Strategic targeting may be a promising avenue for crafting combination resistance treatments' efficacy.

Language: Английский

Citations

8
NETs unleashed: neutrophil extracellular traps boost chemotherapy against colorectal cancer DOI Creative Commons
Alexandra Mousset, Jean Albrengues

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(5)

Published: Feb. 29, 2024

Chemotherapy, which primarily acts on cancer cells, can influence the tumor microenvironment and recruitment behavior of stromal cells. In this issue JCI, Li et al. explored potent anticancer effect combination a glutaminase inhibitor (CB-839) 5-FU against PIK3CA-mutant colorectal tumors. This chemotherapy treatment strongly induced neutrophils that formed neutrophil extracellular traps in cancer, actively killed cells by inducing apoptosis. study substantially advances our understanding multifaceted role NETs outcome treatment.

Language: Английский

Citations

5
Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics DOI Creative Commons
Haisong Li, Can Li, Cong Fu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, tumors. While they help capture eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly achieving precise drug delivery maintaining stability. Nanoparticle (NP)-based systems offer innovative solutions for overcoming limitations conventional therapies. This review explores biological mechanisms formation, their interactions with NPs, therapeutic applications NP-based modulating NETs. We discuss how NPs be designed either promote inhibit provide a comprehensive analysis potential treating NET-related diseases. Additionally, we address current future prospects therapies research, aiming bridge gap between nanotechnology development novel approaches.

Language: Английский

Citations

0
Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24 DOI Creative Commons
Yu Liu,

Jianhui Ma,

Yiming Ma

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(2), P. e010813 - e010813

Published: Feb. 1, 2025

Background Phagocytic clearance by macrophages represents a critical immune surveillance mechanism in cancer liver metastasis. Neutrophils, the most abundant cells encountered circulation, play key roles metastasis through neutrophil extracellular traps (NETs). Although NETs promote macrophage phagocytosis during infection, whether they regulate is unknown. The present study aimed to explore of regulating seeding process and mechanisms underlying roles. Methods A lipopolysaccharide-induced NET model was applied role on colorectal (CRC) neutrophils isolated from human peripheral blood were stimulated with PMA release NETs, which collected added cultures different CRC cell lines for vitro studies. Macrophage assessed flow cytometry vivo. RNA-seq microRNA array analyses performed identify pathways regulated downstream molecules. phenotypes evaluated using immunohistochemistry, cytometry, cytokine chemokine arrays. Results both Neutrophil elastase (NE), able inactivate canonical signal protease-activated receptor 2 (PAR2), downregulated phagocytotic checkpoint CD24. Notably, PAR2 deficiency imitated effect Mechanistic studies indicated that inhibiting expression upregulated miR-34a miR-146a CD24 cells. In addition, depletion enhanced recruitment M1 polarization upregulating CSF-1 CXCL1. correlation NETs/NE corroborated specimens. Furthermore, blockade combined an anti-EGFR antibody (cetuximab (CTX)) synergistically phagocytic ability suppressed Conclusions NET-derived inactivated signaling promoted downregulating CD24, functions as Thus, inhibitors CTX may serve novel therapeutic strategy against advanced CRC.

Language: Английский

Citations

0
Protease regulation of tumor-immune cell symbiosis DOI
Lizhi Pang, Yu-Yun Huang,

Jean Huang-Gao

et al.

Trends in cancer, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Colorectal Cancer: Pathogenesis and Targeted Therapy DOI Creative Commons
Jingyuan Li,

Jiashu Pan,

Lisheng Wang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Colorectal cancer (CRC) ranks among the most prevalent malignant neoplasms globally. A growing body of evidence underscores pivotal roles genetic alterations and dysregulated epigenetic modifications in pathogenesis CRC. In recent years, reprogramming tumor cell metabolism has been increasingly acknowledged as a hallmark cancer. Substantial suggests crosstalk between metabolic modifications, highlighting complex interplay genome that warrants further investigation. Biomarkers associated with characteristics CRC hold significant clinical implications. Nevertheless, elucidating genetic, epigenetic, landscapes continues to pose considerable challenges. Here, we attempt summarize key genes driving onset progression related regulators, clarify gene expression signaling pathways regulation, explore potential events reprogramming, providing comprehensive mechanistic explanation for Finally, by integrating reliable targets from genetics, epigenetics, processes promise translation into practice, aim offer more strategies overcome bottlenecks treatment.

Language: Английский

Citations

0