Therapeutic Advances in Psychopharmacology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 1, 2023
Background:
More
than
2%
of
the
general
population
experience
suicidal
ideas
each
year
and
a
large
number
them
will
attempt
suicide.
Evidence-based
therapeutic
options
to
manage
crisis
are
currently
limited.
Objectives:
The
aim
this
study
was
overview
findings
on
use
ketamine
esketamine
for
treatment
acts.
Design:
Systematic
review.
Data
Sources
methods:
PubMed,
article
references,
Clinicaltrials.gov
up
June
30,
2022.
Meta-analyses
published
within
last
2
years
were
also
reviewed.
Results:
We
identified
12
randomized
controlled
trials
with
reduction
ideation
as
primary
objective
14
secondary
objectives.
Intravenous
racemic
superior
control
drugs
(placebo
or
midazolam)
first
72
h,
in
spite
placebo
effects.
Adverse
events
minor
transient.
In
contrast,
intranasal
did
not
differ
from
large-scale
studies.
Limitations,
clinical
considerations,
opportunities
future
research
include
following
points:
effects
when
studying
reduction;
small
concerns
about
blinding
quality
due
dissociative
effects;
no
studies
risk/prevention
acts
mortality;
lack
beyond
affective
disorders;
adolescents
older
people;
knowledge
long-term
side
effects,
notably
liability
abuse;
robust
predictive
markers;
limited
understanding
mechanisms
ideas;
need
improved
assessment
trials;
outpatient
settings,
emergency
room,
liaison
consultation;
administration;
positive
negative
concomitant
treatments.
Conclusion:
Overall,
there
is
compelling
evidence
favorable
short-term
benefit-risk
balance
intravenous
but
esketamine.
place
have
be
defined
multimodal
care
strategy
patients.
Caution
remains
necessary
use,
pharmacovigilance
essential.
JAMA Psychiatry,
Год журнала:
2024,
Номер
81(6), С. 595 - 595
Опубликована: Март 20, 2024
Suicide
rates
in
the
US
increased
by
35.6%
from
2001
to
2021.
Given
that
most
individuals
die
on
their
first
attempt,
earlier
detection
and
intervention
are
crucial.
Understanding
modifiable
risk
factors
is
key
effective
prevention
strategies.
JAMA Psychiatry,
Год журнала:
2024,
Номер
81(6), С. 572 - 572
Опубликована: Фев. 21, 2024
Not
all
people
who
die
by
suicide
have
a
psychiatric
diagnosis;
yet,
little
is
known
about
the
percentage
and
demographics
of
individuals
with
lifetime
attempts
are
apparently
psychiatrically
healthy.
If
such
common,
there
implications
for
risk
screening,
research,
policy,
nosology.
Journal of Medical Internet Research,
Год журнала:
2024,
Номер
26, С. e55913 - e55913
Опубликована: Май 17, 2024
Background
Suicide
is
the
second-leading
cause
of
death
among
adolescents
and
associated
with
clusters
suicides.
Despite
numerous
studies
on
this
preventable
death,
focus
has
primarily
been
single
nations
traditional
statistical
methods.
Objective
This
study
aims
to
develop
a
predictive
model
for
adolescent
suicidal
thinking
using
multinational
data
sets
machine
learning
(ML).
Methods
We
used
from
Korea
Youth
Risk
Behavior
Web-based
Survey
566,875
aged
between
13
18
years
conducted
external
validation
103,874
Norway’s
University
National
General
19,574
adolescents.
Several
tree-based
ML
models
were
developed,
feature
importance
Shapley
additive
explanations
values
analyzed
identify
risk
factors
thinking.
Results
When
trained
South
95%
CI,
XGBoost
reported
an
area
under
receiver
operating
characteristic
(AUROC)
curve
90.06%
(95%
CI
89.97-90.16),
displaying
superior
performance
compared
other
models.
For
United
States
Norway,
achieved
AUROCs
83.09%
81.27%,
respectively.
Across
all
sets,
consistently
outperformed
highest
AUROC
score,
was
selected
as
optimal
model.
In
terms
predictors
thinking,
feelings
sadness
despair
most
influential,
accounting
57.4%
impact,
followed
by
stress
status
at
19.8%.
age
(5.7%),
household
income
(4%),
academic
achievement
(3.4%),
sex
(2.1%),
others,
which
contributed
less
than
2%
each.
Conclusions
integrating
diverse
3
countries
address
suicide.
The
findings
highlight
important
role
emotional
health
indicators
in
predicting
Specifically,
identified
significant
predictors,
stressful
conditions
age.
These
emphasize
critical
need
early
diagnosis
prevention
mental
issues
during
adolescence.
The Lancet Public Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Deaths
from
suicide
are
a
tragic
yet
preventable
cause
of
mortality.
Quantifying
the
burden
to
understand
its
geographical
distribution,
temporal
trends,
and
variation
by
age
sex
is
an
essential
step
in
prevention.
We
aimed
present
comprehensive
set
global,
regional,
national
estimates
burden.
produced
number
deaths
age-standardised
mortality
rates
globally,
regionally,
for
204
countries
territories
1990
2021,
disaggregated
these
results
sex.
The
Global
Burden
Diseases,
Injuries,
Risk
Factors
Study
(GBD)
2021
attributable
were
broken
down
into
two
categories:
those
firearms
other
specified
means.
For
this
analysis,
we
also
mean
at
time
death
suicide,
incidence
attempts
compared
with
deaths,
firearm.
acquired
data
vital
registration,
verbal
autopsy,
surveillance
that
included
23
782
study-location-years
GBD
2021.
Point
calculated
average
1000
randomly
selected
possible
values
age,
sex,
location.
95%
uncertainty
intervals
(UIs)
derived
2·5th
97·5th
percentiles
1000-draw
distribution.
Globally,
746
000
(95%
UI
692
000-800
000)
occurred
including
519
(485
000-556
among
males
227
(200
000-255
females.
rate
has
declined
over
time,
14·9
(12·8-15·7)
per
100
population
9·0
(8·3-9·6)
Regionally,
due
highest
eastern
Europe
(19·2
[17·5-20·8]
000),
southern
sub-Saharan
Africa
(16·1
[14·0-18·3]
central
(14·4
[11·0-19·1]
000).
which
individuals
died
progressively
increased
during
study
period.
males,
was
43·0
years
(38·0-45·8),
increasing
47·0
(43·5-50·6)
females,
it
41·9
(30·9-46·7)
46·9
(41·2-52·8)
requiring
medical
care
consistently
higher
regional
level
females
than
males.
using
substantially
varied
country
region.
suicides
USA,
Uruguay,
Venezuela.
remain
variable
across
locations,
although
have
continued
improve
globally
since
1990s.
This
presents,
first
GBD,
quantification
death,
alongside
throughout
world.
These
analyses
will
help
guide
future
approaches
reduce
consider
public
health
framework
Bill
&
Melinda
Gates
Foundation.
Importance
Previous
reports
regarding
comparative
suicide
incidence
among
US
physicians
vs
nonphysicians
have
been
inconclusive.
Objective
To
estimate
the
national
of
male
and
female
physician
analyze
associated
factors,
comparing
findings
to
general
population.
Design,
Setting,
Participants
This
retrospective
cohort
study
investigated
suicides
aged
25
years
older
in
from
January
2017
December
2021.
The
analysis
took
place
November
2023
September
2024.
National
Violent
Death
Reporting
System
data
30
states
Washington,
DC,
were
used.
Decedents
with
missing
age
or
sex
excluded
for
incidence,
race,
ethnicity,
marital
status
further
analyses.
Exposure
Physician
occupation.
Main
Outcome
Measures
Suicide
rate
ratios
(IRRs)
odds
(aORs)
adjusted
by
age,
sex,
used
compare
preceding
circumstances,
primary
method,
substances.
Results
A
total
448
(354
[79%]
94
[21%]
female;
mean
[SD]
60
[16]
years)
97
467
population
(76
697
20
770
51
[17]
identified.
Female
had
higher
rates
than
(IRR,
1.88;
95%
CI,
1.19-2.83)
2019
1.75;
1.09-2.65),
overall
2021
risk
1.53;
1.23-1.87).
Male
lower
0.84;
0.75-0.93).
Compared
including
all
available
jurisdiction
data,
depressed
mood
(aOR,
1.35;
1.14-1.61;
P
<
.001)
as
well
mental
health
1.66;
1.39-1.97;
.001),
job
2.66;
2.11-3.35;
legal
1.40,
1.06-1.84;
=
.02)
problems
use
poisoning
1.85;
1.50-2.30;
sharp
instruments
4.58;
3.47-6.06;
.001).
Physicians
also
positive
toxicology
caffeine;
poison;
cardiovascular
agents;
benzodiazepines;
anxiolytics,
nonbenzodiazepines,
hypnotics;
drugs
not
prescribed
home
use.
Conclusion
Relevance
These
show
a
compared
nonphysicians.
Comprehensive
multimodal
prevention
strategies
remain
warranted.
Journal of Psychology & Clinical Psychiatry,
Год журнала:
2025,
Номер
16(1), С. 24 - 28
Опубликована: Янв. 1, 2025
Suicide
has
high
human
mortality
(0.5-1.2
million
death
each
year).
However,
it
is
not
well
informed
and
predicable
event
in
the
clinic.
Early
clinical
evidence
suggests
that
a
large
variety
of
risk
factors
(external
internal
stresses)
may
drive
neuropsychiatric
instability
various
suicide
behavior
deaths
sufferers
victims.
Influenced
by
different
sources
(individual
stresses,
genetic
cascade
unknown
pathogenic
consequences),
prevention
treatment
need
ever-growing
revolution-diagnostic
therapeutic
transition
(genetic
study
drug
targeting,
personalized
medicine
other
emotional
supporting)
with
an
unpredictable
way.
To
implement
diagnostic
transition,
bridging
gap
between
symptoms,
molecular
profiling,
psychiatric
intervene
great
medical
importance.
Currently,
neural-psychiatric
relation
realm
integrating
brain
image
provided
profound
knowledge
impacts
experimental
investigations.
introduce
these
system
integrations,
public
health
databases
should
be
analyzed.
Finally,
success
(neuropsychiatric
status,
tool
access,
analysis,
curative
therapies)
clinic
will
ensure
high-quality
pharmaceutical
benefits
for
diathesis-specificity
potential
suffers.
Next
generation
prediction,
pharmacology
landscapes
dawned
near
future.
