Suicidal ideation and behavior in youth in low- and middle-income countries: A brief review of risk factors and implications for prevention DOI Creative Commons
Johanne Renaud, Sasha MacNeil, Lakshmi Vijayakumar

et al.

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 6, 2022

Although global rates of suicide have dropped in the last 30 years, youth low- and middle-income countries (LMICs) continue to be highly represented statistics yet underrepresented research. In this review we present epidemiology suicide, suicidal ideation, attempts among LMICs. We also describe population-level (attitudes toward socioeconomic, societal factors) individual-level clinical psychosocial risk factors, highlighting specific considerations pertaining These factors within population can inform how multi-level prevention strategies may targeted meet their needs. Prevention intervention relying on stepped-care framework focusing population-, community-, individual level targets while considering locally- culturally relevant practices are key addition, systemic approaches favoring school-based family-based interventions important youth. Cross-culturally adapted multimodal targeting heterogeneity that exists healthcare systems, rates, these should accorded a high priority reduce burden

Language: Английский

Ketamine and esketamine in suicidal thoughts and behaviors: a systematic review DOI Creative Commons
Fabrice Jollant, Romain Colle, Thi Mai Loan Nguyen

et al.

Therapeutic Advances in Psychopharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 1, 2023

Background: More than 2% of the general population experience suicidal ideas each year and a large number them will attempt suicide. Evidence-based therapeutic options to manage crisis are currently limited. Objectives: The aim this study was overview findings on use ketamine esketamine for treatment acts. Design: Systematic review. Data Sources methods: PubMed, article references, Clinicaltrials.gov up June 30, 2022. Meta-analyses published within last 2 years were also reviewed. Results: We identified 12 randomized controlled trials with reduction ideation as primary objective 14 secondary objectives. Intravenous racemic superior control drugs (placebo or midazolam) first 72 h, in spite placebo effects. Adverse events minor transient. In contrast, intranasal did not differ from large-scale studies. Limitations, clinical considerations, opportunities future research include following points: effects when studying reduction; small concerns about blinding quality due dissociative effects; no studies risk/prevention acts mortality; lack beyond affective disorders; adolescents older people; knowledge long-term side effects, notably liability abuse; robust predictive markers; limited understanding mechanisms ideas; need improved assessment trials; outpatient settings, emergency room, liaison consultation; administration; positive negative concomitant treatments. Conclusion: Overall, there is compelling evidence favorable short-term benefit-risk balance intravenous but esketamine. place have be defined multimodal care strategy patients. Caution remains necessary use, pharmacovigilance essential.

Language: Английский

Citations

34
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: what do we know and future vistas DOI Open Access
Roger S. McIntyre

Expert Opinion on Drug Safety, Journal Year: 2024, Volume and Issue: 23(5), P. 539 - 542

Published: March 23, 2024

KEYWORDS: Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs)liraglutidesemaglutidetirzepatideweight lossobesityoverweightdiabetesdepressionsuicide

Language: Английский

Citations

16
Lifetime Suicide Attempts in Otherwise Psychiatrically Healthy Individuals DOI
María A. Oquendo, Melanie M. Wall, Shuai Wang

et al.

JAMA Psychiatry, Journal Year: 2024, Volume and Issue: 81(6), P. 572 - 572

Published: Feb. 21, 2024

Not all people who die by suicide have a psychiatric diagnosis; yet, little is known about the percentage and demographics of individuals with lifetime attempts are apparently psychiatrically healthy. If such common, there implications for risk screening, research, policy, nosology.

Language: Английский

Citations

15
Decoding Suicide Decedent Profiles and Signs of Suicidal Intent Using Latent Class Analysis DOI Creative Commons
Yunyu Xiao, Kaiwen Bi,

Paul Siu-Fai Yip

et al.

JAMA Psychiatry, Journal Year: 2024, Volume and Issue: 81(6), P. 595 - 595

Published: March 20, 2024

Suicide rates in the US increased by 35.6% from 2001 to 2021. Given that most individuals die on their first attempt, earlier detection and intervention are crucial. Understanding modifiable risk factors is key effective prevention strategies.

Language: Английский

Citations

15
The moderating role of belongingness in the contribution of depression to suicide ideation following the October 7, 2023, terrorist attack in Israel: A nationwide prospective study DOI
Yossi Levi‐Belz,

Yael Shoval‐Zuckerman,

Carmel Blank

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 356, P. 292 - 299

Published: April 12, 2024

Language: Английский

Citations

13
Machine Learning–Based Prediction of Suicidal Thinking in Adolescents by Derivation and Validation in 3 Independent Worldwide Cohorts: Algorithm Development and Validation Study DOI Creative Commons
Hyejun Kim, Yejun Son, Hojae Lee

et al.

Journal of Medical Internet Research, Journal Year: 2024, Volume and Issue: 26, P. e55913 - e55913

Published: May 17, 2024

Background Suicide is the second-leading cause of death among adolescents and associated with clusters suicides. Despite numerous studies on this preventable death, focus has primarily been single nations traditional statistical methods. Objective This study aims to develop a predictive model for adolescent suicidal thinking using multinational data sets machine learning (ML). Methods We used from Korea Youth Risk Behavior Web-based Survey 566,875 aged between 13 18 years conducted external validation 103,874 Norway’s University National General 19,574 adolescents. Several tree-based ML models were developed, feature importance Shapley additive explanations values analyzed identify risk factors thinking. Results When trained South 95% CI, XGBoost reported an area under receiver operating characteristic (AUROC) curve 90.06% (95% CI 89.97-90.16), displaying superior performance compared other models. For United States Norway, achieved AUROCs 83.09% 81.27%, respectively. Across all sets, consistently outperformed highest AUROC score, was selected as optimal model. In terms predictors thinking, feelings sadness despair most influential, accounting 57.4% impact, followed by stress status at 19.8%. age (5.7%), household income (4%), academic achievement (3.4%), sex (2.1%), others, which contributed less than 2% each. Conclusions integrating diverse 3 countries address suicide. The findings highlight important role emotional health indicators in predicting Specifically, identified significant predictors, stressful conditions age. These emphasize critical need early diagnosis prevention mental issues during adolescence.

Language: Английский

Citations

10
Development and Pilot Testing of the Mobile Application to Prevent Suicide (MAPS) DOI
Heather T. Schatten, Christopher D. Hughes, Sara Kimble

et al.

Cognitive Therapy and Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

Citations

1
Suicide prevention strategies in South Korea: what we have learned and the way forward DOI
Dae Hun Kang,

Andrea Horvath Marques,

Jeong Hun Yang

et al.

Asian Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 104, P. 104359 - 104359

Published: Jan. 9, 2025

Language: Английский

Citations

1
Making Progress in Clinical Trials for Suicide Prevention DOI
Samuel T. Wilkinson, Craig J. Bryan, Larry Alphs

et al.

JAMA Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Importance Suicide is a public health crisis, and despite renewed efforts to confront this problem, suicide rates continue rise in the US. While prevention encompasses broad array of strategies, treatment development lagging. Within realm, clinical trials are criterion standard for evaluating safety efficacy new treatments. Observations Most conducted among patients with mental illness have excluded at risk suicide. Historical reasons include regulatory challenges, liability concerns, ethical questions, discomfort working directly high-risk patients, belief that research too risky individuals elevated Conclusions Relevance Several considerations provided investigators design targeting at-risk populations, including thoughtful selection study outcome, use time-to-event analysis (which may simultaneously satisfy concerns scientific aims), enrolling an enriched sample (eg, recently discharged from hospital), provision usual care comparator group. Caution should be exercised avoid excessive or unreasonable requirements, which lead participants minimize self-report suicidal ideation drop out trials. Where possible, bodies (institutional review boards [IRBs] data monitoring boards) consult as members those direct experience population. An important principle IRB other regulators consider suicide-related events expected

Language: Английский

Citations

1
Human suicide, clinical treatment overview DOI Open Access
Da-Yong Lu

Journal of Psychology & Clinical Psychiatry, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 28

Published: Jan. 1, 2025

Suicide has high human mortality (0.5-1.2 million death each year). However, it is not well informed and predicable event in the clinic. Early clinical evidence suggests that a large variety of risk factors (external internal stresses) may drive neuropsychiatric instability various suicide behavior deaths sufferers victims. Influenced by different sources (individual stresses, genetic cascade unknown pathogenic consequences), prevention treatment need ever-growing revolution-diagnostic therapeutic transition (genetic study drug targeting, personalized medicine other emotional supporting) with an unpredictable way. To implement diagnostic transition, bridging gap between symptoms, molecular profiling, psychiatric intervene great medical importance. Currently, neural-psychiatric relation realm integrating brain image provided profound knowledge impacts experimental investigations. introduce these system integrations, public health databases should be analyzed. Finally, success (neuropsychiatric status, tool access, analysis, curative therapies) clinic will ensure high-quality pharmaceutical benefits for diathesis-specificity potential suffers. Next generation prediction, pharmacology landscapes dawned near future.

Language: Английский

Citations

1