A Large-Scale Examination of Attention-Deficit/Hyperactivity Disorder Behaviors and Family Functioning Over Time Using Random-Intercept Cross-Lagged Panel Modeling

JAACAP Open, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Neurobiology of attention-deficit hyperactivity disorder: historical challenges and emerging frontiers

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(12), С. 759 - 775

Опубликована: Окт. 24, 2024

Язык: Английский

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Psychiatric neuroimaging designs for individualised, cohort, and population studies

Neuropsychopharmacology, Год журнала: 2024, Номер 50(1), С. 29 - 36

Опубликована: Авг. 14, 2024

Abstract Psychiatric neuroimaging faces challenges to rigour and reproducibility that prompt reconsideration of the relative strengths limitations study designs. Owing high resource demands varying inferential goals, current designs differentially emphasise sample size, measurement breadth, longitudinal assessments. In this overview perspective, we provide a guide landscape psychiatric with respect balance scientific goals constraints. Through heuristic data cube contrasting key design features, discuss resulting trade-off among small sample, precision studies (e.g., individualised cohorts) large minimally longitudinal, population studies. Precision support tests within-person mechanisms, via intervention tracking course. Population generalisation across multifaceted individual differences. A proposed reciprocal validation model (RVM) aims recursively leverage these complementary in sequence accumulate evidence, optimise strengths, build towards improved long-term clinical utility.

Язык: Английский

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Putative epicenters identified by transcriptome-neuromorphic interactions in attention-deficit/hyperactivity disorder biotypes

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер 136, С. 111247 - 111247

Опубликована: Янв. 1, 2025

Язык: Английский

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Toward individual heterogeneity and neurobiological subtypes in attention-deficit/hyperactivity disorder

Journal of Pacific Rim Psychology, Год журнала: 2025, Номер 19

Опубликована: Янв. 1, 2025

Attention-deficit/hyperactivity disorder (ADHD) is a biologically and clinically heterogeneous neurodevelopmental condition, which hinders the identification of rooted evidence for treatment choices clinical predictions. Identifying brain-based homogenous ADHD subtypes with neuroimaging data to reduce this heterogeneity promising elucidating specific neural mechanisms underlying complex presentations, may enable development personalized treatments precise therapeutic targets. In review, we first discuss large individual differences among patients indicated by findings from both large-scale group-level studies individual-level studies, motivated new efforts discover neurobiological subtypes. Next, review recent research on neuroimaging-based in terms three aspects: sample selection, subtyping methodology (i.e., features, algorithms, validation strategies), subtype findings. Eleven utilizing multiple single modalities or multimodal were identified. Through diverse features approaches, current have revealed range different characterized distinct profiles, providing important insight into nature ADHD. Despite progress, most still little biological relevance, limited utility, generalizability, slowing down pace their translation. We highlight several crucial considerations overcome these challenges contribute more useful reproducible identification. With increasing access datasets, deliberate features/methods adequate strategies, believe that could be used inform treatments, thereby advancing practice towards precision psychiatry.

Язык: Английский

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Neural basis for individual differences in the attention-enhancing effects of methylphenidate

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(13)

Опубликована: Март 24, 2025

Stimulant drugs that boost dopamine, like methylphenidate (MP), enhance attention and are effective treatments for attention-deficit hyperactivity disorder (ADHD). Yet there is large individual variation in attentional capacity response to MP. It unclear whether this driven by differences relative density of dopamine receptor subtypes, magnitude increases induced MP, or both. Here, we extensively characterized the brain system with positron emission tomography (PET) imaging (including striatal D1 D2/3 availability MP-induced increases) measured task-evoked fMRI activity two separate sessions (placebo 60 mg oral MP; single-blind, counterbalanced) 37 healthy adults. A network lateral frontoparietal visual cortices was sensitive increasing (and working memory) load, whose positively correlated performance across individuals (partial r = 0.474, P 0.008; controlling age). change within 0.686, < 0.001). The ratio D1-to-D2/3 receptors dorsomedial caudate baseline negatively changes (all pFWE 0.02). load mediated association between improvements (mediation estimate 23.20 [95%CI: -153.67 -81.79], 0.004). MP attention-boosting effects were not linked increases, but rather showed dependence on an individual's density. Individuals lower ratios tended have during sustained experienced greater improvement function task

Язык: Английский

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Cross-sectional mega-analysis of resting-state alterations associated with autism and attention-deficit/hyperactivity disorder in children and adolescents

Nature Mental Health, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Язык: Английский

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Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics

World Journal of Pediatrics, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Язык: Английский

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Functional connectivity of the nucleus accumbens predicts clinical course in medication adherent and non-adherent adult ADHD

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Июнь 4, 2025

Язык: Английский

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Psychiatric Neuroimaging Designs for Individualised, Cohort, and Population Studies

Опубликована: Апрель 22, 2024

Psychiatric neuroimaging faces challenges to rigour and reproducibility that prompt reconsideration of the relative strengths limitations study designs. Owing high resource demands varying inferential goals, current designs differentially emphasise sample size, measurement breadth, longitudinal assessments. In this overview perspective, we provide a guide landscape psychiatric with respect balance scientific goals constraints. Through heuristic data cube contrasting key design features, discuss resulting tradeoff among small sample, precision studies (e.g., individualised cohorts) large minimally longitudinal, population studies. Precision support tests within-person mechanisms, via intervention tracking course. Population generalisation across multifaceted individual differences. A proposed reciprocal validation model (RVM) aims recursively leverage these complementary in sequence accumulate evidence, optimise strengths, build towards improved long-term clinical utility.

Язык: Английский

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