Twin Research and Human Genetics,
Год журнала:
2025,
Номер
unknown, С. 1 - 8
Опубликована: Апрель 22, 2025
Abstract
Although
financial
stressors
are
implicated
as
risk
factors
for
suicidal
behavior,
these
associations
might
be
confounded
by
other
factors.
Furthermore,
a
move
toward
high-risk
subgroup
definition
is
necessary.
The
authors
used
Swedish
national
registry
data
to
examine
the
between
receipt
of
social
welfare,
unemployment
benefits,
or
early
retirement
(
N
=
627,745−2,260,753)
with
behavior
in
Cox
proportional
hazards
models.
They
applied
co-relative
models
improve
causal
inference,
and
examined
interactions
aggregate
genetic
suicidality.
All
three
exposures
were
associated
elevated
risk.
Initial
hazard
ratios
suicide
attempt
ranged
from
1.37−3.86,
similar
death,
declined
after
controlling
psychopathology
time
elapsed
exposure.
Age
at
registration
differentially
impacted
behavior.
Aggregate
liability
suicidality
was
risk,
but
its
effect
not
moderated
stress.
Financial
even
psychopathology.
Associations
attributable
part
familial
confounding,
though
potentially
pathway
observed
most
cases.
Suicidality
varied
function
sex
age
exposure;
findings
could
identify
subgroups
high
who
warrant
targeted
prevention.
Complex Psychiatry,
Год журнала:
2025,
Номер
11(1), С. 1 - 11
Опубликована: Фев. 13, 2025
Introduction:
Research
has
identified
multiple
risk
factors
associated
with
suicide
attempt
(SA)
among
individuals
psychiatric
illness.
However,
there
is
limited
research
those
an
alcohol
use
disorder
(AUD),
despite
their
disproportionately
higher
rates
of
SA.
Methods:
We
examined
lifetime
SA
in
4,068
AUD
from
the
Collaborative
Study
on
Genetics
Alcoholism
(23%
SA;
53%
female;
mean
age:
38).
explored
for
across
other
clinical
conditions
ascertained
a
interview,
polygenic
scores
comorbid
problems,
and
neurocognitive
functioning.
Results:
Participants
who
attempted
had
greater
trauma
exposure,
major
depressive
disorder,
post-traumatic
stress
substance
disorders
(SUDs),
suicidal
ideation.
Polygenic
SA,
depression,
PTSD
were
increased
odds
reporting
(ORs
=
1.22–1.44).
reported
also
decreased
right
hemispheric
frontal-parietal
theta
interhemispheric
temporal-parietal
alpha
electroencephalogram
resting-state
coherences
relative
to
did
not,
but
differences
small.
Conclusions:
Overall,
report
experience
levels
trauma,
have
more
severe
comorbidities,
carry
problems.
Our
results
demonstrate
need
further
investigate
SAs
presence
SUDs.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 18, 2024
Numerous
studies
highlight
the
genetic
underpinnings
of
mental
disorders
comorbidity,
particularly
in
anxiety,
depression,
and
schizophrenia.
However,
their
shared
loci
are
not
well
understood.
Our
study
employs
Mendelian
randomization
(MR)
colocalization
analyses,
alongside
multi-omics
data,
to
uncover
potential
targets
for
these
conditions,
thereby
informing
therapeutic
drug
development
strategies.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 15, 2024
Multiple
lines
of
evidence
indicate
that
altered
dopamine
signaling
may
be
involved
in
neuropsychiatric
disorders
and
common
behavioral
traits.
Here
we
critically
review
collected
during
the
past
40-plus
years
supporting
role
dysfunction
attention
deficit
hyperactivity
disorder
(ADHD).
We
recapitulate
basic
components
dopaminergic
central
nervous
system,
focusing
on
core
enzymes,
transporters
receptors
monoaminergic
functions,
particularly
striatal
cortical
regions.
summarize
key
human
brain
imaging
genetic
studies
reporting
associations
between
neurotransmission
traits,
with
an
emphasis
ADHD.
also
consider
ADHD
context
animal
models
single
gene,
metabolic,
neurological
established
system.
Examining
this
way
leads
us
to
conclude
there
is
for
involvement
but
limited
a
hypo-dopaminergic
state
per
se
as
component
propose
path
forward
increase
our
understanding
traits
should
focus
its
clinical
subgroups,
development
how
it
interacts
other
neurotransmitter
systems.
Cell Genomics,
Год журнала:
2024,
Номер
4(10), С. 100631 - 100631
Опубликована: Окт. 1, 2024
Glycemic
traits
are
critical
indicators
of
maternal
and
fetal
health
during
pregnancy.
We
performed
genetic
analysis
for
five
glycemic
in
14,744
Chinese
pregnant
women.
Our
genome-wide
association
study
identified
25
locus-trait
associations,
including
established
links
between
gestational
diabetes
mellitus
(GDM)
the
genes
CDKAL1
MTNR1B.
Notably,
we
discovered
a
novel
fasting
glucose
pregnancy
ESR1
gene
(estrogen
receptor),
which
was
validated
by
an
independent
The
ESR1-GDM
link
recently
reported
FinnGen
project.
work
enhances
findings
East
Asian
populations
highlights
need
studies.
Further
analyses,
correlation,
Mendelian
randomization,
transcriptome-wide
studies,
provided
insights
into
relationship
hypertension.
Overall,
our
advance
understanding
architecture
traits,
especially
populations.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(2), С. 593 - 593
Опубликована: Янв. 19, 2024
Background:
Suicide
remains
a
persistent
global
health
challenge,
resisting
widespread
prevention
efforts.
According
to
previous
findings,
toxoplasmosis
is
particularly
associated
with
altered
decision
making,
which
could
lead
risk-taking
behavior,
thereby
increasing
the
likelihood
for
suicidal
behavior
(SB).
In
addition,
discussion
about
role
of
microbiome
in
psychiatric
disorders
has
emerged
lately,
also
makes
it
relevant
investigate
its
context
SB.
Therefore,
two
systematic
reviews
are
integrated
this
paper,
and
existing
knowledge
comprehensively
summarized
regarding
association
between
microbial
pathogens
Methods:
We
conducted
search
keywords
including
SB
Toxoplasma
gondii
(Suicid*
AND
Toxoplasm*)
Microbiome
Microbiota)
throughout
PubMed
Scopus
retrieve
related
studies
up
9
November
2023,
identifying
24
eligible
records.
The
subjects
included
had
have
fulfilled
criteria
an
disorder
as
defined
by
DSM-5,
death
cases
needed
been
suicide.
Results:
Most
reported
significant
SB,
suggesting
higher
infected
population.
Regarding
microbiome,
only
very
few
investigated
alterations
microbiome.
Based
on
six
studies,
there
were
some
indications
link
changes
Conclusion:
cognitive
aspects
making
T.
gondii-infected
individuals
should
be
further
unravel
underlying
mechanisms.
Further
sufficiently
powered
establish
