SCARF Genes in COVID-19 and Kidney Disease: A Path to Comorbidity-Specific Therapies DOI Open Access
Sol Carriazo, Daria Abasheva,

Deborah Duarte

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16078 - 16078

Опубликована: Ноя. 8, 2023

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has killed ~7 million persons worldwide. Chronic kidney (CKD) is the most common risk factor for severe COVID-19 and one that increases of COVID-19-related death. Moreover, CKD injury (AKI), patients with AKI are at an increased However, molecular basis underlying this not been well characterized. death from multiple infections, to immune deficiency in non-specific host defenses may contribute. COVID-19-associated specific features modulates local (kidney) systemic (lung, aorta) expression genes encoding coronavirus-associated receptors factors (SCARFs), SARS-CoV-2 hijacks enter cells replicate. We review interaction between COVID-19, including over 200 influence severity provide evidence suggesting modulate SCARF other key involved effective adaptive defense against coronaviruses. Given poor response certain populations (e.g., transplant recipients) vaccines their suboptimal outcomes when infected, we propose a research agenda focusing on develop concept comorbidity-specific targeted therapeutic approaches infection or future infections.

Язык: Английский

Autoimmune hepatitis under the COVID-19 veil: an analysis of the nature of potential associations DOI Creative Commons
Chaojie Yu, Wenrui Wang, Qian Zhang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 31, 2025

In recent years, the novel coronavirus infectious disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to over 670 million infections and nearly 7 deaths worldwide. The global pandemic of COVID-19 precipitated a significant public health crisis. prevalence liver function abnormalities associated with SARS-CoV-2 is as high 53% among healthy individuals or patients autoimmune hepatitis (AIH) shows positive correlation severity; moreover, specific adaptive immune responses can influence trajectory outcomes COVID-19. For instance, may impact autoimmunity through mechanisms such excessive stimulation molecular mimicry, particularly in genetically predisposed individuals. Currently, overall mutational trend indicates heightened infectivity evasion capabilities. Consequently, vaccination remains crucial for universal protection against this disease. Nevertheless, alongside widespread implementation programs globally, an increasing number cases have been documented where appears trigger new-onset hepatitis; yet definitive evidence still pending elucidation regarding causality. review, we analyse clinical-immunological characteristics, risks progression, prognosis AIH infected SARS-CoV-2; discuss detrimental effects exerted on hepatic function; summarise attributes leading AIH; well provide insights into how interfere processes. We continue underscore significance while aiming enhance awareness concerning potential it-this could facilitate better management strategies diseases along appropriate adjustments protocols. Although precise triggering mechanism linking COVID-19-related events unclear, existing suggests that relationship far from coincidental.

Язык: Английский

Процитировано

0
Cytokine storm polymorphisms in nonvaccinated COVID-19 patients DOI
Laura E. Martínez-Gómez,

Carla Isabel Oropeza-Vélez,

Maylin Almonte‐Becerril

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Cytokines and chemokines are essential for establishing an appropriate immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Variations in the genes encoding cytokines strongly influence pathogenic challenges disease outcomes. This study was carried out determine associations of polymorphisms TNF -α , IL-6 IL-8, IL-10 CCL5 with COVID-19 severity. A total 627 unvaccinated patients were classified according WHO We evaluated levels IFN-α, IFN-γ, TNF-α, IL-1R, IL-6, IL-7, IL-10, CCL2, CCL3, CXCL8, CXCL10 GCSF serum compared among severity groups stratified by polymorphism alleles. revealed a significant increase IL-2, CCL-2 dead group. However, higher moderate group than mild Logistic regression analysis that five associated increased risk COVID-19: (rs1800610) allele (OR=1.50; 95% CI: 1.01–2.24); (rs1800796) C (OR=1.64; 1.05–2.57); (rs1800871) T (OR=1.94; 1.24–3.04) (rs1800872) (OR=1.87; 1.21–2.89); (rs3817656) G (OR= 1.64; 1.02–2.65)). The (rs1800871 rs1800872) (rs1800796 rs18049563) gene also Increases carriers rs1049953. In contrast, not any SNPs.

Язык: Английский

Процитировано

0
Screening Biomarkers and Risk Factors for COVID-19 Progression in a Border Population Between Brazil-Bolivia DOI Creative Commons
Ana Maísa Passos-Silva, Adrhyan Araújo, Tárcio Peixoto Roca

и другие.

Biomedical Engineering and Computational Biology, Год журнала: 2025, Номер 16

Опубликована: Апрель 1, 2025

The performance and genetic role in host response delineate investigative points of polymorphisms as potential biomarkers viral infections. Thus, this research aimed to map risk factors the severity COVID-19 individuals Western Amazon (n = 243). Patients aged 40 59 years showed an association with clinical progression (P .003), also evidencing relationship for >60 < .001), besides non-vaccination influenced pathology .023). qPCR human genotyping targets rs2070788, rs4702, rs76635825, rs540856718, rs35803318, rs12979860, rs16899066, well gene expression ACE2, HLA-A, HLA-B, IFNL-3/2, IL-6, TMPRSS2 was used. rs12979860 (C > T) rs2070788 (A G) among analyzed groups .05) allelic genotypic frequency (x 2 3.84) evolutionary pointing rs2070788G allele infected people, including deaths. Gene high levels between moderate severe groups, emphasis on IL-6 genes that performed better. there is possibly regarding rs2070788G, age COVID-19, parallel considerable influence vaccine SARS-CoV-2 pathway.

Язык: Английский

Процитировано

0
A COMPREHENSIVE REVIEW ON THE MULTIFACETED INTERACTIONS BETWEEN HOST IMMUNITY AND VIRAL PATHOGENESIS IN COVID-19 DOI Open Access
Mairembam Stelin Singh, Sailu Yellaboina,

MAIRAJ AHMED ANSARI

и другие.

International Journal of Applied Pharmaceutics, Год журнала: 2024, Номер unknown, С. 37 - 45

Опубликована: Июль 7, 2024

The Corona Virus Disease (COVID-19) pandemic has presented unparalleled challenges, marked by a wide array of clinical presentations spanning from asymptomatic carriage to severe respiratory compromise and multi-organ dysfunction. It is crucial comprehend the intricate interplay between host immunity viral pathogenesis elucidate disease mechanisms guide therapeutic strategies. This review delves into multifaceted interactions in COVID-19, with particular focus on impact factors such as age, sex, comorbidities, genetic predisposition severity. Utilizing state-of-the-art methodologies, including multiomics approaches, yielded an expansive molecular portrayal furnishing innovative perspectives immune reactions, pathogenicity, advancement. Establishing standardized methodologies for data analysis interpretation while concurrently addressing ethical considerations promoting interdisciplinary collaboration are steps advancing our comprehension COVID-19 pathogenesis. Despite obstacles like complexities integration, this highlights imperative persistent endeavors deciphering complex hosts pathogens alleviate global health ramifications COVID-19.

Язык: Английский

Процитировано

1
Molecular genetic association of rs8099917 and rs1800795 polymorphisms in the progression of hepatitis Delta virus liver disease DOI Creative Commons
Ana Maísa Passos-Silva, Eugênia de Castro e Silva, Lourdes Maria Pinheiro Borzacov

и другие.

˜The œJournal of venomous animals and toxins including tropical diseases, Год журнала: 2024, Номер 30

Опубликована: Янв. 1, 2024

Background: The relationship between viral infections and host factors holds high hopes for identifying the role of Interferon Lambda 3 (IFNL3) Interleukin 6 (IL-6) polymorphisms in development Chronic Liver Disease (CLD) patients infected with hepatitis Delta virus (HDV) Western Brazilian Amazon. Methods: Cross-sectional study conducted a cohort 40 chronic HDV patients, 27 CLD 13 without evident liver damage. Biological samples from participants were analyzed using polymerase chain reaction (PCR) technique, followed by sequencing automated Sanger method. Results: rs8099917 T allele, IFNL3 gene, showed higher frequency both groups; however, it was not possible to establish an association infection [OR = 1.42 (0.42 - 4.75; p 0.556 (95% CI). For IL-6, rs1800795 G allele superior C. Analyzing distributions studied groups, any absent (p > 0.05). Conclusion: results suggest that T/G G/C are associated evolution population.

Язык: Английский

Процитировано

0
Interleukin-mediated therapies in liver diseases and comorbidity effects DOI Open Access
Nouhoum Bouare, Jean Delwaide

World Journal of Hepatology, Год журнала: 2024, Номер 16(7), С. 980 - 989

Опубликована: Июль 26, 2024

Cytokines like interleukins (ILs) play important roles in inflammation and innate immune. Yang Zhang carried out an interesting study related to ILs hepatic diseases. They described the role of pathogenesis resolution disorders. The authors summarized alcohol-related liver disease virus-induced hepatitis, as far clinical studies

Язык: Английский

Процитировано

0
SCARF Genes in COVID-19 and Kidney Disease: A Path to Comorbidity-Specific Therapies DOI Open Access
Sol Carriazo, Daria Abasheva,

Deborah Duarte

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16078 - 16078

Опубликована: Ноя. 8, 2023

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has killed ~7 million persons worldwide. Chronic kidney (CKD) is the most common risk factor for severe COVID-19 and one that increases of COVID-19-related death. Moreover, CKD injury (AKI), patients with AKI are at an increased However, molecular basis underlying this not been well characterized. death from multiple infections, to immune deficiency in non-specific host defenses may contribute. COVID-19-associated specific features modulates local (kidney) systemic (lung, aorta) expression genes encoding coronavirus-associated receptors factors (SCARFs), SARS-CoV-2 hijacks enter cells replicate. We review interaction between COVID-19, including over 200 influence severity provide evidence suggesting modulate SCARF other key involved effective adaptive defense against coronaviruses. Given poor response certain populations (e.g., transplant recipients) vaccines their suboptimal outcomes when infected, we propose a research agenda focusing on develop concept comorbidity-specific targeted therapeutic approaches infection or future infections.

Язык: Английский

Процитировано

0