International Journal of Polymer Science,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
This
study
is
aimed
at
developing
alginate
hydrogel
filaments
enriched
with
TEMPO
(2,2,6,6‐tetramethylpiperidine‐1‐oxyl
radical)–oxidized
cellulose
nanofibers
(TOCNs)
through
3D‐printing
techniques
for
application
in
bone
tissue
engineering.
The
were
designed
to
act
as
advanced
biomaterials
that
support
regeneration
by
combining
dissolved
phosphate
ions
TOCNs,
followed
extrusion
into
a
calcium
chloride
solution.
process
facilitated
the
cross‐linking
of
and
situ
mineralization
phosphate.
produced
characterized
using
variety
techniques,
including
scanning
electron
microscopy
(SEM),
Fourier
transform
infrared
spectroscopy
(FTIR),
thermogravimetric
analysis
(TGA).
Additionally,
biomineralization
tests
confirmed
successful
formation
apatite.
Mechanical
testing
revealed
significant
increase
tensile
strength,
ranging
from
40
80
MPa,
which
underscores
improved
structural
integrity
hydrogels.
Rheological
assessments
demonstrated
addition
TOCNs
enhanced
viscoelastic
properties
filaments,
making
them
more
suitable
applications.
Cytotoxicity
further
biocompatibility
scaffolds,
showing
cell
proliferation.
These
results
suggest
incorporating
hydrogels
offers
promising
approach
functional
engineering,
particularly
Journal of Tissue Engineering,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
The
field
of
three
dimensional
(3D)
bioprinting
has
witnessed
significant
advancements,
with
bioinks
playing
a
crucial
role
in
enabling
the
fabrication
complex
tissue
constructs.
This
review
explores
innovative
that
are
currently
shaping
future
3D
bioprinting,
focusing
on
their
composition,
functionality,
and
potential
for
engineering,
drug
delivery,
regenerative
medicine.
development
bioinks,
incorporating
natural
synthetic
materials,
offers
unprecedented
opportunities
personalized
However,
rapid
technological
progress
raises
regulatory
challenges
regarding
safety,
standardization,
long-term
biocompatibility.
paper
addresses
these
challenges,
examining
current
frameworks
need
updated
guidelines
to
ensure
patient
safety
product
efficacy.
By
highlighting
both
hurdles,
this
comprehensive
overview
landscape
emphasizing
necessity
cross-disciplinary
collaboration
between
scientists,
clinicians,
bodies
achieve
successful
clinical
applications.
Journal of Functional Biomaterials,
Год журнала:
2023,
Номер
14(10), С. 497 - 497
Опубликована: Окт. 8, 2023
Within
the
human
body,
intricate
network
of
blood
vessels
plays
a
pivotal
role
in
transporting
nutrients
and
oxygen
maintaining
homeostasis.
Bioprinting
is
an
innovative
technology
with
potential
to
revolutionize
this
field
by
constructing
complex
multicellular
structures.
This
technique
offers
advantage
depositing
individual
cells,
growth
factors,
biochemical
signals,
thereby
facilitating
functional
vessels.
Despite
challenges
fabricating
vascularized
constructs,
bioprinting
has
emerged
as
advance
organ
engineering.
The
continuous
evolution
biomaterial
knowledge
provides
avenue
overcome
hurdles
associated
tissue
fabrication.
article
overview
biofabrication
process
used
create
vascular
constructs.
It
delves
into
various
techniques
engineering,
including
extrusion-,
droplet-,
laser-based
methods.
Integrating
these
prospect
crafting
artificial
remarkable
precision
functionality.
Therefore,
impact
engineering
significant.
With
technological
advances,
it
holds
promise
revolutionizing
transplantation,
regenerative
medicine.
By
mimicking
natural
complexity
vessels,
brings
us
one
step
closer
organs
vasculature,
ushering
new
era
medical
advancement.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12766 - 12766
Опубликована: Ноя. 27, 2024
Bone
defects
and
fractures
present
significant
clinical
challenges,
particularly
in
orthopedic
maxillofacial
applications.
While
minor
bone
may
be
capable
of
healing
naturally,
those
a
critical
size
necessitate
intervention
through
the
use
implants
or
grafts.
The
utilization
traditional
methodologies,
encompassing
autografts
allografts,
is
constrained
by
several
factors.
These
include
potential
for
donor
site
morbidity,
restricted
availability
suitable
donors,
possibility
immune
rejection.
This
has
prompted
extensive
research
field
tissue
engineering
to
develop
advanced
synthetic
bio-derived
materials
that
can
support
regeneration.
optimal
substitute
must
achieve
balance
between
biocompatibility,
bioresorbability,
osteoconductivity,
osteoinductivity
while
simultaneously
providing
mechanical
during
process.
Recent
innovations
three-dimensional
printing,
nanotechnology,
bioactive
coatings
create
scaffolds
mimic
structure
natural
enhance
cell
proliferation
differentiation.
Notwithstanding
advancements
above,
challenges
remain
optimizing
controlled
release
growth
factors
adapting
various
contexts.
review
provides
comprehensive
overview
current
materials,
focusing
on
their
biological
mechanisms,
design
considerations,
It
explores
role
emerging
technologies,
such
as
additive
manufacturing
stem
cell-based
therapies,
advancing
field.
Future
highlights
need
multidisciplinary
collaboration
rigorous
testing
graft
substitutes,
improving
outcomes
quality
life
patients
with
complex
defects.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
3D
extrusion
bioprinting,
a
promising
and
widely
adopted
technology
in
the
emerging
field
of
biofabrication,
has
gained
considerable
attention
for
its
ability
to
fabricate
hierarchically
structured,
native-mimicking
tissue
substitutes
with
precisely
defined
cell
distributions.
Despite
notable
advancements,
limited
availability
suitably
bioactive
bioinks
remains
major
challenge,
hindering
construction
volumetric
effectively
mimicking
biological
functionality.
Therefore,
this
work
proposes
protein-rich,
low-cost,
bioink:
abundantly
available
eggwhite
powder
(EWP)
is
leveraged
functionalize
an
alginate-methylcellulose
(AlgMC)
hydrogel
matrix
enhance
cellular
response.
The
developed
EWP-supplemented
not
only
maintain
favorable
printability
high
shape
fidelity
but
also
exhibit
remarkable
bioactivity.
Notably,
incorporating
EWP
into
AlgMC-based
enhances
shear-thinning
features,
thereby
improving
viability
encapsulated
cells
within
bioprinted
constructs.
versatility
biofunctionality
constructs
are
demonstrated
using
three
distinct
types,
encompassing
sources
such
as
stem
line,
human
soft
skin,
stiff
bone
tissues.
Furthermore,
wide
applicability
bioink
biofabrication
exemplarily
core-shell
multi-channel
bioprinting
strategies
proof-of-concept
functional
construction.
These
findings
underscore
significant
versatile
potential
novel
biomedical
applications.
The
pendant
drop
experiment
can
be
used
to
study
the
interfacial
tension
of
a
liquid.
Here
we
perform
similar
for
granular
system.
When
dense
aggregate
cohesive
particles
extrudes
from
an
orifice,
cluster
detaches,
detachment
liquid
drop.
We
investigate
volume
clusters
formed
close-packed
oil
droplets
in
aqueous
solution.
Our
findings
reveal
that
depends
on
size
orifice
as
well
cohesion
strength.
Interestingly,
observe
droplet
does
not
significantly
impact
average
volume.
establish
simple
scaling
law
governs
which
differs
classic
propose
key
difference
between
continuum
and
systems
is
constraints
rearrangements
within
prevent
adopting
minimal
surface
structure,
case
Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 22, 2025
Additive
manufacturing
(AM)
is
revolutionizing
healthcare
by
enabling
the
creation
of
customized
3D
printed
(3DP)
medical
equipment,
implants,
orthoses,
prosthetics,
drugs,
and
organs.
With
availability
different
types
materials
suitable
for
3DP
applications,
this
technology
allows
precise
fabrication
patient-oriented
dental
orthopedic
devices,
significantly
improving
fit
functionality.
Additionally,
such
as
Oral
Dispersible
Formulations
(ODFs)
polypills,
are
surpassing
traditional
“one
pill
fits
all”
concept,
offering
more
tailored
medication
solutions.
This
innovation
also
supports
development
personalized
medications
bioprinted
tissues,
opening
way
advancements
in
regenerative
therapies.
3D-bioprinted
organs
addressing
growing
demand
organ
transplants.
In
surgical
planning,
3D-printed
anatomical
models
provide
students
professionals
with
hands-on
practice,
which
crucial
skill
understanding
complex
anatomies.
Surgeons
can
practice
refine
techniques
before
actual
procedures,
enhancing
precision
outcomes
during
real
operations.
paper
focus
on
highlighting
progression
motivations
behind
cross-disciplinary
applications
AM
within
sector
providing
drug
delivery
systems
diagnostic
tools
treatment
refinement.
designed
a
broad
audience,
including
researchers,
who
interested
exploring
implications
transformative
technology.
