Neuropharmacology,
Год журнала:
2023,
Номер
226, С. 109418 - 109418
Опубликована: Янв. 6, 2023
Psychiatric
disorders
associated
with
psychological
trauma,
stress
and
anxiety
are
a
highly
prevalent
increasing
cause
of
morbidity
worldwide.
Current
therapeutic
approaches,
including
medication,
effective
in
alleviating
symptoms
posttraumatic
disorder
(PTSD),
at
least
some
individuals,
but
have
unwanted
side-effects
do
not
resolve
underlying
pathophysiology.
After
period
stagnation,
there
is
renewed
enthusiasm
from
public,
academic
commercial
parties
designing
developing
drug
treatments
for
these
disorders.
Here,
we
aim
to
provide
snapshot
the
current
state
this
field
that
written
neuropharmacologists,
also
practicing
clinicians
interested
lay-reader.
introducing
currently
available
treatments,
summarize
recent/ongoing
clinical
assessment
novel
medicines
PTSD,
grouped
according
primary
neurochemical
targets
their
potential
produce
acute
and/or
enduring
effects.
The
evaluation
putative
targeting
monoamine
(including
psychedelics),
GABA,
glutamate,
cannabinoid,
cholinergic
neuropeptide
systems,
amongst
others,
discussed.
We
emphasize
importance
clinically
assessing
new
medications
based
on
firm
understanding
neurobiology
stemming
rapid
advances
being
made
neuroscience.
This
includes
harnessing
neuroplasticity
bring
about
lasting
beneficial
changes
brain
rather
than
–
as
many
transient
attenuation
symptoms,
exemplified
by
combining
psychotropic/cognitive
enhancing
drugs
psychotherapeutic
approaches.
conclude
noting
other
emerging
trends
promising
phase
development.
Molecules,
Год журнала:
2025,
Номер
30(2), С. 322 - 322
Опубликована: Янв. 15, 2025
Agomelatine
(AGM)
is
an
effective
antidepressant
with
low
oral
bioavailability
due
to
intensive
hepatic
metabolism.
Transdermal
administration
of
agomelatine
may
increase
its
and
reduce
the
doses
necessary
for
therapeutic
effects.
However,
transdermal
delivery
requires
crossing
stratum
corneum
barrier.
For
this
purpose,
use
microneedles
efficiency
administration.
The
aim
study
was
prepare
agomelatine-loaded
hydrogel
suitable
coating
drug
AGM.
optimized
formulations
were
subjected
spectroscopic
rheological
characterization
mechanical
tests,
as
well
tested
release
through
artificial
membrane
permeation
human
skin
ex
vivo.
Both
hydrogels
found
have
parameters
using
dip-coating
method,
including
stability
substance
at
process
temperature,
shear-thinning
behavior,
appropriate
textural
such
adhesion
or
hardness.
Additionally,
two
potential
application
alone
because
gels
showed
properties
application.
In
case,
ethanol
gel
characterized
by
higher
permeability
better
spreadability.
information
obtained
in
will
allow
preparation
coated
agomelatine.
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 407 - 407
Опубликована: Фев. 9, 2024
Emotional
experiences
are
a
part
of
our
lives.
The
maladaptive
functioning
an
individual's
emotional
field
can
lead
to
disturbances
various
kinds,
such
as
anxiety
and
depression.
Currently,
there
is
increasing
prevalence
disorders
that
cause
great
human
suffering
high
socioeconomic
costs.
processing
has
biological
basis.
major
neuroscientific
theories
emotion
based
on
functioning,
all
them
take
into
account
the
anatomy
function
tenth
cranial
nerve:
vagus
nerve.
nerve
connects
subdiaphragmatic
supradiaphragmatic
areas
modulates
basis
interoceptive
functioning.
Auricular
stimulation
new
innovative
neuromodulation
technique
Several
interventions
have
shown
this
neurostimulation
very
promising
resource
for
treating
disorders.
In
paper,
we
summarise
three
emotion,
explain
what
transcutaneous
auricular
is,
present
arguments
its
use
continued
research.
Current Opinion in Psychiatry,
Год журнала:
2022,
Номер
36(2), С. 140 - 145
Опубликована: Дек. 6, 2022
Purpose
of
review
This
examines
recent
evidence
that
informs
the
treatment
anxiety-related
disorders.
Recent
findings
In
addition
to
selective
serotonin
reuptake
inhibitors
(SSRIs),
and
norepinephrine
(SNRIs),
benzodiazepines,
agomelatine
has
demonstrated
efficacy
in
treating
generalized
anxiety
disorder
(GAD).
Other
novel
products,
such
as
ketamine,
psilocybin
cannabidiol,
are
process
gathering
support
psychological
therapy,
various
treatments
for
disorders,
mindfulness-based
intervention,
acceptance
commitment
psychodynamic
emotion-focused
therapy
dialectical
behavioural
have
been
tried.
Still,
most
therapies
not
proven
superior
cognitive
(CBT).
very
preliminary
findings:
Repetitive
transcranial
magnetic
stimulation
(rTMS)
was
effective
GAD;
direct
current
(tDCS)
social
(SAD)
GAD
augmented
exposure
specific
fears.
Internet
mobile-based
interventions
comparable
face-to-face
therapy.
Summary
Pharmacotherapy
disorders
is
expanding
products.
Despite
trying
other
were
but
CBT.
rTMS
tDCS
also
used
show
early
promise
GAD,
further
studies
needed.
Most
internet
or
mobile
app
based
on
CBT,
some
can
be
considered
alternatives
in-person
Journal of Mood and Anxiety Disorders,
Год журнала:
2024,
Номер
6, С. 100058 - 100058
Опубликована: Фев. 24, 2024
Improving
mindfulness
is
an
important
treatment
target
for
generalized
anxiety
disorder
(GAD).
However,
less
known
about
how
different
treatments
impact
specific
aspects
of
mindfulness.
In
a
clinical
trial
(Simon
et
al.,
2021),
226
individuals
with
GAD
were
randomized
to
12
weeks
Kundalini
Yoga
(KY),
cognitive
behavioral
therapy
(CBT)
or
stress
education
(SE).
To
examine
whether
facets
mindfulness,
as
measured
by
the
Five
Facet
Mindfulness
Questionnaire
(FFMQ)
change
more
than
others
across
and
between
treatments,
we
ran
multi-variate
multilevel
growth
curve
model
(MMLM).
Results
indicated
that
while
Non-judge,
Act
Awareness,
Non-react
increased
significantly
during
treatment,
Observe
Describe
did
not.
Improvement
in
Acting
Awareness
facet
was
greater
KY
CBT.
These
findings
reveal
need
better
understand
can
influence
components
those
anxiety.
