Global trends and research status in clonal hematopoiesis: a bibliometric analysis of the last 10 years DOI
QingQing Luo, Li Yu

Опубликована: Апрель 28, 2025

Abstract Objective: Clonal hematopoiesis (CH) refers to the clonal expansion of hematopoietic stem cells caused by somatic mutations. CH is commonly observed in elderly individuals and closely associated with myeloid malignancies as well various non-malignant diseases. This study aims explore research trends hotspots using bibliometric analysis. Methods: Relevant studies were retrieved from Web Science Core Collection database based on predefined inclusion criteria. Bibliometric analysis visualization conducted VOSviewer, CiteSpace, R software. Results: A total 851 included. From 2014 2024, annual number publications showed a consistent upward trend. The United States was identified leading country this field, contributing 53.7% publications. Harvard Medical School Benjamin L Ebert recognized most influential institution author, respectively. Blood prolific journal, highest citation H-index. Research CH-related gene mutations their association risk acute leukemia currently extensively studied area, while cardiovascular diseases inflammation have emerged recent hotspots. Conclusion: first systematically analyze related methods. Our reveals overall landscape identifies contributors including countries, institutions, authors, journals. Moreover, we identify emerging key areas, highlighting potential avenues for exploration innovation within field CH.

Язык: Английский

Immune effector cell-associated haematotoxicity after CAR T-cell therapy: from mechanism to management DOI
Kai Rejeski, Michael D. Jain, Nirali N. Shah

и другие.

The Lancet Haematology, Год журнала: 2024, Номер 11(6), С. e459 - e470

Опубликована: Май 8, 2024

Язык: Английский

Процитировано

22
The Epigenetic Hallmarks of Cancer DOI
Manel Esteller, Mark A. Dawson, Cigall Kadoch

и другие.

Cancer Discovery, Год журнала: 2024, Номер 14(10), С. 1783 - 1809

Опубликована: Окт. 4, 2024

Abstract Cancer is a complex disease in which several molecular and cellular pathways converge to foster the tumoral phenotype. Notably, latest iteration of cancer hallmarks, “nonmutational epigenetic reprogramming” was newly added. However, epigenetics, much like genetics, broad scientific area that deserves further attention due its multiple roles initiation, progression, adaptive nature. Herein, we present detailed examination hallmarks affected human cancer, elucidating genes involved, dissecting disrupted landscapes for DNA methylation, histone modifications, chromatin architecture define disease. Significance: characterized by constant evolution, spanning from initial premalignant stages advanced invasive disseminated stages. It pathology able adapt survive amidst hostile microenvironments diverse treatments implemented medical professionals. The more fixed setup genetic structure cannot fully provide transformed cells with tools but rapid plastic nature changes ready task. This review summarizes ecological success our bodies.

Язык: Английский

Процитировано

16
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs DOI
Mohsen Hosseini, Véronique Voisin,

Ali Chegini

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

1
Clinical application of the Lung Cancer Compact PanelTM using various types of cytological specimens in patients with lung cancer DOI Creative Commons
Kei Kunimasa, Motohiro Tamiya,

Takako Inoue

и другие.

Lung Cancer, Год журнала: 2024, Номер 189, С. 107498 - 107498

Опубликована: Фев. 3, 2024

BackgroundThe Lung Cancer Compact PanelTM (compact panel) is a gene panel that can detect driver alterations with high sensitivity in liquid samples, including tumor cells. This study examined the ability of compact to genetic mutations specimens used clinical practice.MethodsThree cohorts, bronchoscopic biopsy forceps washing (washing cohort), pleural effusion (pleural and spinal fluid (spinal were analyzed using panel. Liquid samples added into GM (GeneMetrics) tubes analyzed. The cohort assessed concordance rate analysis outcomes tissue derived from primary tumor. Meanwhile, investigated impact storing for 8 weeks more on nucleic acid mutation detection rates.ResultsIn (n = 79), detected tissues was 75/79 (94.9 %). reached 100 % when focusing solely treatment. 8) showed no deterioration quality or quantity after storage tubes. Similarly, 9), malignant cells exhibited similar those These findings underscore efficacy accurately identifying different specimens.ConclusionsThe reliable tool detecting various cytological specimens. Its consistent performance across diverse sample types emphasizes its potential guiding targeted therapies patients lung cancer enhancing precision medicine approaches.

Язык: Английский

Процитировано

7
Natural history of clonal haematopoiesis seen in real‐world haematology settings DOI
Shyam A. Patel,

William K Gerber,

Rena Zheng

и другие.

British Journal of Haematology, Год журнала: 2024, Номер 204(5), С. 1844 - 1855

Опубликована: Март 24, 2024

Summary Recursive partitioning of healthy consortia led to the development Clonal Hematopoiesis Risk Score (CHRS) for clonal haematopoiesis (CH); however, in practical setting, most cases CH are diagnosed after patients present with cytopenias or related symptoms. To address this real‐world population, we characterize clinical trajectories 94 and distinguish harbouring canonical DNMT3A/TET2/ASXL1 mutations alone (‘sole DTA’) versus all other groups (‘non‐sole DTA’). TET2 , rather than DNMT3A was prevalent mutation setting. Sole DTA did not progress myeloid neoplasm (MN) absence acquisition mutations. Contrastingly, 14 (20.1%) 67 non‐sole progressed MN. CHRS assessment showed a higher frequency high‐risk (vs. sole DTA) progressors non‐progressors). RUNX1 conferred strongest risk progression MN (odds ratio [OR] 10.27, 95% CI 2.00–52.69, p = 0.0053). The mean variant allele across genes non‐progressors (36.9% ± 4.62% vs. 24.1% 1.67%, 0.0064). This analysis post‐CHRS era underscores natural history CH, providing insight into patterns

Язык: Английский

Процитировано

5
Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL) DOI Creative Commons

Attila Kállai,

Zoltán Ungvári, Mónika Fekete

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 15, 2024

Abstract Aging is a multifaceted process characterized by gradual decline in physiological function and increased susceptibility to range of chronic diseases. Among the molecular cellular mechanisms driving aging, genomic instability fundamental hallmark, contributing mutation load genetic heterogeneity within populations. This review explores role aging hematopoietic system, with particular focus on clonal hematopoiesis indeterminate potential (CHIP), monoclonal gammopathy undetermined significance (MGUS), B-cell lymphocytosis (MBL) as biomarkers. CHIP involves expansion stem cells somatic mutations. In contrast, MGUS presence plasma producing immunoglobulins, while MBL proliferation B cells. These conditions are prevalent population serve measurable indicators underlying instability. Studying these entities offers valuable insights into which mutations accumulate drive evolution providing deeper understanding how impacts tissue homeostasis. summary, system serves powerful model for investigating interplay between aging. Incorporating age-related hematological research, alongside other biomarkers such epigenetic clocks, can enhance precision predictive power biological age assessments. provide comprehensive view process, facilitating early detection diseases hopefully enabling personalized healthcare strategies.

Язык: Английский

Процитировано

5
Clinical decision-making and treatment of myelodysplastic syndromes DOI

Eva S. Hellström-Lindberg,

Nicolaus Kröger

Blood, Год журнала: 2023, Номер 142(26), С. 2268 - 2281

Опубликована: Окт. 24, 2023

Язык: Английский

Процитировано

12
Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity DOI Creative Commons
Tianqi Ma, Chen Zhu, Xunjie Cheng

и другие.

JACC Basic to Translational Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Are rs1042059 and rs11591377 polymorphisms of BMI1 gene related to leukemia? DOI
A. Farid,

Zeinab Eftekhar,

Zari Tahannejad Asadi

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

0
Heart Failure Post-Hematopoietic Cell Transplantation in Patients With Lymphoma DOI Creative Commons
Oscar Calvillo‐Argüelles, Robert Vanner

JACC CardioOncology, Год журнала: 2025, Номер 7(1), С. 34 - 37

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0