Global trends and research status in clonal hematopoiesis: a bibliometric analysis of the last 10 years DOI
QingQing Luo, Li Yu

Published: April 28, 2025

Abstract Objective: Clonal hematopoiesis (CH) refers to the clonal expansion of hematopoietic stem cells caused by somatic mutations. CH is commonly observed in elderly individuals and closely associated with myeloid malignancies as well various non-malignant diseases. This study aims explore research trends hotspots using bibliometric analysis. Methods: Relevant studies were retrieved from Web Science Core Collection database based on predefined inclusion criteria. Bibliometric analysis visualization conducted VOSviewer, CiteSpace, R software. Results: A total 851 included. From 2014 2024, annual number publications showed a consistent upward trend. The United States was identified leading country this field, contributing 53.7% publications. Harvard Medical School Benjamin L Ebert recognized most influential institution author, respectively. Blood prolific journal, highest citation H-index. Research CH-related gene mutations their association risk acute leukemia currently extensively studied area, while cardiovascular diseases inflammation have emerged recent hotspots. Conclusion: first systematically analyze related methods. Our reveals overall landscape identifies contributors including countries, institutions, authors, journals. Moreover, we identify emerging key areas, highlighting potential avenues for exploration innovation within field CH.

Language: Английский

Immune effector cell-associated haematotoxicity after CAR T-cell therapy: from mechanism to management DOI
Kai Rejeski, Michael D. Jain, Nirali N. Shah

et al.

The Lancet Haematology, Journal Year: 2024, Volume and Issue: 11(6), P. e459 - e470

Published: May 8, 2024

Language: Английский

Citations

22
The Epigenetic Hallmarks of Cancer DOI
Manel Esteller, Mark A. Dawson, Cigall Kadoch

et al.

Cancer Discovery, Journal Year: 2024, Volume and Issue: 14(10), P. 1783 - 1809

Published: Oct. 4, 2024

Abstract Cancer is a complex disease in which several molecular and cellular pathways converge to foster the tumoral phenotype. Notably, latest iteration of cancer hallmarks, “nonmutational epigenetic reprogramming” was newly added. However, epigenetics, much like genetics, broad scientific area that deserves further attention due its multiple roles initiation, progression, adaptive nature. Herein, we present detailed examination hallmarks affected human cancer, elucidating genes involved, dissecting disrupted landscapes for DNA methylation, histone modifications, chromatin architecture define disease. Significance: characterized by constant evolution, spanning from initial premalignant stages advanced invasive disseminated stages. It pathology able adapt survive amidst hostile microenvironments diverse treatments implemented medical professionals. The more fixed setup genetic structure cannot fully provide transformed cells with tools but rapid plastic nature changes ready task. This review summarizes ecological success our bodies.

Language: Английский

Citations

16
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs DOI
Mohsen Hosseini, Véronique Voisin,

Ali Chegini

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

1
Clinical application of the Lung Cancer Compact PanelTM using various types of cytological specimens in patients with lung cancer DOI Creative Commons
Kei Kunimasa, Motohiro Tamiya,

Takako Inoue

et al.

Lung Cancer, Journal Year: 2024, Volume and Issue: 189, P. 107498 - 107498

Published: Feb. 3, 2024

BackgroundThe Lung Cancer Compact PanelTM (compact panel) is a gene panel that can detect driver alterations with high sensitivity in liquid samples, including tumor cells. This study examined the ability of compact to genetic mutations specimens used clinical practice.MethodsThree cohorts, bronchoscopic biopsy forceps washing (washing cohort), pleural effusion (pleural and spinal fluid (spinal were analyzed using panel. Liquid samples added into GM (GeneMetrics) tubes analyzed. The cohort assessed concordance rate analysis outcomes tissue derived from primary tumor. Meanwhile, investigated impact storing for 8 weeks more on nucleic acid mutation detection rates.ResultsIn (n = 79), detected tissues was 75/79 (94.9 %). reached 100 % when focusing solely treatment. 8) showed no deterioration quality or quantity after storage tubes. Similarly, 9), malignant cells exhibited similar those These findings underscore efficacy accurately identifying different specimens.ConclusionsThe reliable tool detecting various cytological specimens. Its consistent performance across diverse sample types emphasizes its potential guiding targeted therapies patients lung cancer enhancing precision medicine approaches.

Language: Английский

Citations

7
Natural history of clonal haematopoiesis seen in real‐world haematology settings DOI
Shyam A. Patel,

William K Gerber,

Rena Zheng

et al.

British Journal of Haematology, Journal Year: 2024, Volume and Issue: 204(5), P. 1844 - 1855

Published: March 24, 2024

Summary Recursive partitioning of healthy consortia led to the development Clonal Hematopoiesis Risk Score (CHRS) for clonal haematopoiesis (CH); however, in practical setting, most cases CH are diagnosed after patients present with cytopenias or related symptoms. To address this real‐world population, we characterize clinical trajectories 94 and distinguish harbouring canonical DNMT3A/TET2/ASXL1 mutations alone (‘sole DTA’) versus all other groups (‘non‐sole DTA’). TET2 , rather than DNMT3A was prevalent mutation setting. Sole DTA did not progress myeloid neoplasm (MN) absence acquisition mutations. Contrastingly, 14 (20.1%) 67 non‐sole progressed MN. CHRS assessment showed a higher frequency high‐risk (vs. sole DTA) progressors non‐progressors). RUNX1 conferred strongest risk progression MN (odds ratio [OR] 10.27, 95% CI 2.00–52.69, p = 0.0053). The mean variant allele across genes non‐progressors (36.9% ± 4.62% vs. 24.1% 1.67%, 0.0064). This analysis post‐CHRS era underscores natural history CH, providing insight into patterns

Language: Английский

Citations

5
Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL) DOI Creative Commons

Attila Kállai,

Zoltán Ungvári, Mónika Fekete

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Aging is a multifaceted process characterized by gradual decline in physiological function and increased susceptibility to range of chronic diseases. Among the molecular cellular mechanisms driving aging, genomic instability fundamental hallmark, contributing mutation load genetic heterogeneity within populations. This review explores role aging hematopoietic system, with particular focus on clonal hematopoiesis indeterminate potential (CHIP), monoclonal gammopathy undetermined significance (MGUS), B-cell lymphocytosis (MBL) as biomarkers. CHIP involves expansion stem cells somatic mutations. In contrast, MGUS presence plasma producing immunoglobulins, while MBL proliferation B cells. These conditions are prevalent population serve measurable indicators underlying instability. Studying these entities offers valuable insights into which mutations accumulate drive evolution providing deeper understanding how impacts tissue homeostasis. summary, system serves powerful model for investigating interplay between aging. Incorporating age-related hematological research, alongside other biomarkers such epigenetic clocks, can enhance precision predictive power biological age assessments. provide comprehensive view process, facilitating early detection diseases hopefully enabling personalized healthcare strategies.

Language: Английский

Citations

5
Clinical decision-making and treatment of myelodysplastic syndromes DOI

Eva S. Hellström-Lindberg,

Nicolaus Kröger

Blood, Journal Year: 2023, Volume and Issue: 142(26), P. 2268 - 2281

Published: Oct. 24, 2023

Language: Английский

Citations

12
Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity DOI Creative Commons
Tianqi Ma, Chen Zhu, Xunjie Cheng

et al.

JACC Basic to Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Are rs1042059 and rs11591377 polymorphisms of BMI1 gene related to leukemia? DOI
A. Farid,

Zeinab Eftekhar,

Zari Tahannejad Asadi

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 18, 2025

Language: Английский

Citations

0
Heart Failure Post-Hematopoietic Cell Transplantation in Patients With Lymphoma DOI Creative Commons
Oscar Calvillo‐Argüelles, Robert Vanner

JACC CardioOncology, Journal Year: 2025, Volume and Issue: 7(1), P. 34 - 37

Published: Jan. 1, 2025

Language: Английский

Citations

0