A breath of the future: a novel human model for COPD and beyond DOI
Maja C. Funk, Janna Nawroth, Mareike Lehmann

и другие.

European Respiratory Journal, Год журнала: 2024, Номер 64(6), С. 2401531 - 2401531

Опубликована: Дек. 1, 2024

Extract We have cured chronic lung diseases, including COPD, in mice many times. However, translation to clinical application has failed most cases. Why is this the case and what can we do about it? One of reasons for that are simply not small humans. Developing novel human models will help us identifying more promising therapeutic strategies, thereby hopefully leading options translate clinic.

Язык: Английский

The Association Between the CALLY Index and All-Cause Mortality in Patients with COPD: Results from the Cohort Study of NHANES 2007–2010 DOI Creative Commons

Ding Yu,

Yuxia Liu,

Jianjian Yu

и другие.

International Journal of COPD, Год журнала: 2025, Номер Volume 20, С. 159 - 169

Опубликована: Янв. 1, 2025

Purpose:The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a newly developed biomarker that combines measurements of CRP, serum albumin, and lymphocyte count.This provides thorough assessment patient's inflammation level, nutritional condition, immunological function.The objective this study to examine the correlation between CALLY all-cause mortality in COPD patients.Methods: We calculated using data from National Health Nutrition Examination Survey (NHANES) for 2007-2008 2009-2010 cycles, extracted participants' peripheral blood samples.The utilized Kaplan-Meier curves, restricted cubic spline (RCS) Cox regression analysis evaluate relationship risk patients.To assess predictive accuracy index, we area under receiver operating characteristic (ROC) curve (AUC). Results:The included 1,048 participants found significant negative patients with COPD.The was major predictor survival [fully adjusted model: 3rd quartile, HR = 1.61, 95% CI: 1.02-2.52,p 0.039; 2nd 2.11, 1.22-3.65,p 0.008; 1st 3.12, 2.00-4.85,p < 0.001].The RCS curves demonstrated non-linear association patients.The areas (AUC) predicting 5-and 10-year were 0.693 0.656. Conclusion:The has strong US could serve as prognostic these patients.

Язык: Английский

Процитировано

2
Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study DOI Creative Commons
Zhenghua Cao, Tong Wu,

Yakun Fang

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 28, 2024

This study employed Mendelian Randomization (MR) to investigate the causal relationships among immune cells, COPD, and potential metabolic mediators. Utilizing summary data from genome-wide association studies, we analyzed 731 cell phenotypes, 1,400 plasma metabolites, COPD. Bidirectional MR analysis was conducted explore links between cells complemented by two-step mediation multivariable identify mediating metabolites. Causal were identified 41 phenotypes with 6 exhibiting reverse causality. Additionally, 21 metabolites causally related Through analyses, 8 found have COPD mediated (including one unidentified), 1-methylnicotinamide levels showing highest proportion at 26.4%. We These findings contribute screening of individuals high risk for offer insights into early prevention precocious diagnosis Pre-COPD.

Язык: Английский

Процитировано

4
Inherent immunity and adaptive immunity: Mechanism and role in AECOPD DOI Creative Commons

Linguangjin Wu,

Eryun Zhang, Yadan Tu

и другие.

Innate Immunity, Год журнала: 2025, Номер 31

Опубликована: Янв. 1, 2025

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the leading cause hospitalization and mortality in COPD patients. The occurrence antibiotic resistance progression non-infectious diseases contribute to poor patient outcomes. Thus, a comprehensive understanding mechanisms underlying AECOPD essential for effective prevention. It widely acknowledged that immune system plays fundamental role pathogen clearance development inflammation. Immune dysregulation, either due deficiency or hyperactivity, has been implicated pathogenesis. Therefore, purpose this review investigate possible dysregulated function patients, specifically focusing on innate adaptive responses. ultimate aim provide new insights clinical prevention treatment strategies targeting AECOPD.

Язык: Английский

Процитировано

0
Advances in acute COPD exacerbation: clarifying specific immune mechanisms of infectious and noninfectious factors DOI Creative Commons
Yadan Tu, Yong Chen,

Xuanhan Li

и другие.

Therapeutic Advances in Respiratory Disease, Год журнала: 2025, Номер 19

Опубликована: Янв. 1, 2025

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main cause hospitalization and death patients with disease. This largely due to bacterial resistance caused by clinical antibiotic abuse limited efficacy current treatment strategies in managing noninfectious AECOPD, which presents a significant challenge for clinicians. Therefore, it urgent prevention AECOPD fully understand specific mechanism immune system master key differences between infectious factors factors. article systematically discusses triggered various factors, including activation system, recruitment inflammatory cells role responses, through comprehensive review literature, this expounds existing targeted diagnosis methods technologies at different stages order provide new ideas AECOPD.

Язык: Английский

Процитировано

0
ERJ2024: your journal, my journal, our journal DOI Open Access
Don D. Sin, James D. Chalmers

European Respiratory Journal, Год журнала: 2024, Номер 63(1), С. 2302215 - 2302215

Опубликована: Янв. 1, 2024

Our 5-year mission at the European Respiratory Journal ( ERJ ) is to be best journal in respiratory medicine, publish outstanding science and "go-to" educational source for you, our readers [1]. To achieve these lofty goals, we have carefully listened your suggestions, made some significant changes implemented new initiatives 2023 (with more come 2024). How done thus far? There are coming 2024

Язык: Английский

Процитировано

1
Correlation-based network integration of lung RNA sequencing and DNA methylation data in chronic obstructive pulmonary disease DOI Creative Commons
Pasquale Sibilio, Federica Conte, Yichen Huang

и другие.

Heliyon, Год журнала: 2024, Номер 10(10), С. e31301 - e31301

Опубликована: Май 1, 2024

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous, chronic inflammatory process of the lungs and, like other complex diseases, caused by both genetic and environmental factors. Detailed understanding molecular mechanisms diseases requires study interplay among different biomolecular layers, thus integration omics data types. In this study, we investigated COPD-associated through correlation-based network lung tissue RNA-seq DNA methylation COPD cases (n = 446) controls 346) derived from Lung Tissue Research Consortium. First, performed SWIM-network based analysis to build separate correlation networks for our case-control population. Then, developed method integrate results into

Язык: Английский

Процитировано

0
Lipogenic Lung Fibroblast-derived Extracellular Vesicles Mitigate Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Pathologies through LAT1-mediated Alveolar Type II Cell Restoration DOI Creative Commons
Shota Fujimoto,

Yuta Hirano,

Naoaki Watanabe

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Abstract Emerging research has revealed specific cellular aberrations in Chronic Obstructive Pulmonary Disease (COPD), with a particular focus on alveolar type 2 (AT2) cells, which play pivotal role the restoration of damaged lung tissue and promotion normal differentiation. Lipofibroblasts (LipoFBs), are stromal fibroblasts that house lipid droplets, have been identified close proximity to AT2 cells demonstrated support function. In this study, we present comprehensive investigation into therapeutic potential extracellular vesicles (EVs) derived from LipoFBs (LipoFB-EVs) COPD treatment. They effectively mitigate key pathologies such as senescence inflammatory responses epithelial cells. This is achieved by reducing reactive oxygen species (ROS) levels modulating DNA damage response pathways. Moreover, LipoFB-EVs demonstrate antifibrotic properties inhibiting TGF-β-induced myofibroblast differentiation, surpassing conventional drugs. also aid restoring impaired stem crucial for homeostasis, enhancing their viability, colony-forming ability, proliferation. Furthermore, identify presence L-type amino acid transporter 1 (LAT1) within LipoFB-EVs, mediates uptake, particularly leucine transport, contributes cell dysfunction. Importantly, administration murine models resulted significant improvements airway inflammation, remodeling, obstruction, senescence, emphysema induced both short- long-term CS exposure. Overall, our findings highlight novel regenerative therapy COPD, offering promising avenues future clinical interventions.

Язык: Английский

Процитировано

0
Inflammatory and Immune Mechanisms in COPD: Current Status and Therapeutic Prospects DOI Creative Commons

Yanan Qi,

Yuanyuan Yan,

Da-Wei Tang

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 6603 - 6618

Опубликована: Сен. 1, 2024

Chronic obstructive pulmonary disease (COPD) currently ranks among the top three causes of mortality worldwide, presenting as a prevalent and complex respiratory ailment. Ongoing research has underscored pivotal role immune function in onset progression COPD. The response COPD patients exhibits abnormalities, characterized by diminished anti-infection capacity due to senescence, heightened activation neutrophils macrophages, T cell infiltration, aberrant B activity, collectively contributing airway inflammation lung injury

Язык: Английский

Процитировано

0
COPD-iNET: a call to the lung community for action to combat the global epidemic of COPD DOI
Ali Önder Yildirim, Thomas M. Conlon, Ian M. Adcock

и другие.

European Respiratory Journal, Год журнала: 2024, Номер 64(3), С. 2400921 - 2400921

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0
A breath of the future: a novel human model for COPD and beyond DOI
Maja C. Funk, Janna Nawroth, Mareike Lehmann

и другие.

European Respiratory Journal, Год журнала: 2024, Номер 64(6), С. 2401531 - 2401531

Опубликована: Дек. 1, 2024

Extract We have cured chronic lung diseases, including COPD, in mice many times. However, translation to clinical application has failed most cases. Why is this the case and what can we do about it? One of reasons for that are simply not small humans. Developing novel human models will help us identifying more promising therapeutic strategies, thereby hopefully leading options translate clinic.

Язык: Английский

Процитировано

0