Application of bronchoscopy in the diagnosis and treatment of peripheral pulmonary lesions in China: a national cross-sectional study

Journal of Cancer, Год журнала: 2023, Номер 14(8), С. 1398 - 1406

Опубликована: Янв. 1, 2023

Background: Bronchoscopy has gradually become valuable armamentarium in evaluating and applying endoscopic therapy to peripheral pulmonary lesions (PPLs) around the world.We aimed make a comprehensive understanding of application bronchoscopy diagnosis treatment PPLs China.Methods: A cross-sectional survey was carried out China between January 2022 March 2022.The form an online questionnaire which filled with real-time data by respondents.Results: total 347 doctors from 284 tertiary hospitals (81.8%) 63 secondary general (18.2%) were included analysis.More than half surveyed (55.0%) had independently performed respiratory endoscopy for 5-15 years.Higher proportions fixed nursing team, anesthesiologists rapid on-site evaluation (ROSE) during bronchoscopic procedures those (P<0.001each).There 316 (91.7%) eligible performing biopsies less 30mm, while more 300 only 78 (24.7%) per year.Radial probe endobronchial ultrasound (r-EBUS) (50.3%) commonest type technique used guidance bronchoscope PPLs, followed navigational (30.3%) cone beam CT (CBCT) (17.0%).Although two thirds at least one devices, actual utilization these devices not high due capital costs absence training.To note, diagnostic allocated concentrated southeast region coastal cities.Furthermore, therapeutic interventions lung cancer and/or high-risk could be 124 (35.7%) involved hospitals.Conclusions: been most yields different regions varied greatly.To date, few can develop PPLs.

Язык: Английский

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Transbronchial lung cryobiopsy for peripheral pulmonary lesions. A narrative review

Pulmonology, Год журнала: 2023, Номер 30(5), С. 475 - 484

Опубликована: Окт. 31, 2023

An increasing number of peripheral pulmonary lesions (PPLs) requiring tissue verification to establish a definite diagnosis for further individualized management are detected due the growing adoption lung cancer screening by chest computed tomography (CT), especially low-dose CT. However, morphological PPLs remains challenging. Transbronchial cryobiopsy (TBLC) that can retrieve larger specimens with more preserved cellular architecture and fewer crush artifacts in comparison conventional transbronchial forceps biopsy (TBFB), as an emerging technology diagnosing PPLs, has been demonstrated have potential resolve clinical dilemma pertaining currently available sampling devices (e.g., forceps, needle brush) become diagnostic cornerstone PPLs. Of note, introduction 1.1 mm cryoprobe will be compatible advanced bronchoscopic navigation techniques, such radial endobronchial ultrasound (r-EBUS), virtual (VBN) electromagnetic bronchoscopy (ENB), use TBLC is expected gain popularity While much exploration using technique it envisaged emergence additional studies data accrual hopefully add body evidence this field.

Язык: Английский

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Multimodality Imaging with Confocal Endomicroscopy, Red Dichromatic Imaging, and Virtual Bronchoscopic Navigation Guided Recanalization of Complete Airway Obstruction Caused by Tracheobronchial Amyloidosis

Archivos de Bronconeumología, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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A review on diagnostic assessments of tracheal stenosis

BioMedical Engineering OnLine, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 14, 2025

Язык: Английский

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Advancements in Imaging Technologies for the Diagnosis of Lung Cancer and Other Pulmonary Diseases

Diagnostics, Год журнала: 2025, Номер 15(7), С. 826 - 826

Опубликована: Март 25, 2025

Advancements in imaging technologies have redefined pulmonary medicine, with increased diagnostic accuracy and improved clinical outcomes. This review discusses the evolving landscape of advancements, including pivotal role low-dose computed tomography (CT) lung cancer screening transformative impact endobronchial ultrasound on staging. Imaging techniques like high-resolution CT remain indispensable for diagnosis monitoring parenchymal diseases. Positron emission (PET) is increasingly being used inflammatory conditions sarcoidosis. In pleural diseases, thoracic essential diagnosing performing bedside procedures safely. Advanced modalities ventilation scans also been to target persistent air leaks. emphasizes importance advancements field medicine underscores continued innovation integration these advancements.

Язык: Английский

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Radial endobronchial ultrasound - guided bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta-analysis of prospective trials

Heliyon, Год журнала: 2024, Номер 10(8), С. e29446 - e29446

Опубликована: Апрель 1, 2024

The diagnostic yield of radial endobronchial ultrasound (r-EBUS) for the diagnosis peripheral pulmonary lesions (PPLs) varies between studies and is affected by multiple factors. We aimed to evaluate efficacy safety r-EBUS, explore factors influencing r-EBUS in patients with PPLs.

Язык: Английский

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Real-time and non-invasive acute lung rejection diagnosis using confocal LASER Endomicroscopy in lung transplant recipients: Results from the CELTICS study

Pulmonology, Год журнала: 2024, Номер 31(1)

Опубликована: Фев. 24, 2024

Traditionally, the diagnosis of acute rejection (AR) relies on invasive transbronchial biopsies (TBBs) to obtain histopathological samples. We aimed evaluate diagnostic yield probe-based confocal laser endomicroscopy (pCLE) as a complementary and non-invasive tool for ACR screening, comparing its results with those obtained from TBBs. Between January 2015 April 2022, we conducted retrospective study all lung transplant recipients aged over 18 years at Toulouse University Hospital (France). All patients who underwent bronchoscopies both TBBs pCLE imaging were included. Two experienced interpreters (TV MS) reviewed images independently, blinded clinical information pathology results. From 120 procedures in 85 patients, 34 abnormal histological samples identified. Probe-based revealed significant associations between alveolar (ALC) perivascular (PVC) cellularities (p<0.0001 0.003 respectively). Alveolar cellularity demonstrated sensitivity (Se) 85.3 %, specificity (Spe) 43 positive predictive value (PPV) 37.2 % negative (NPV) 88.1 %. For PVC, Se was 70.6 Spe 80.2 PPV 58.5 NPV 87.3 Intra-interpreter correlation (TV) 88.3 number vessels (+/-1), 98.3 ALC 90 PVC. Inter-interpreter 80 97.5 83.3 Our demonstrates feasibility incorporating into practice, demonstrating good reproducible outcomes screening AR recipients.

Язык: Английский

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ETV6-NTRK2 Fusion in a Patient With Metastatic Pulmonary Atypical Carcinoid Successfully Treated With Entrectinib: A Case Report and Review of the Literature

Clinical Lung Cancer, Год журнала: 2024, Номер 25(3), С. 215 - 224.e3

Опубликована: Март 19, 2024

Язык: Английский

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Predictive value of the resistance of the probe to pass through the lesion in the diagnosis of peripheral pulmonary lesions using radial probe endobronchial ultrasound with a guide sheath

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Июль 31, 2023

Transbronchial lung biopsy guided by radial probe endobronchial ultrasonography with a guide sheath (EBUS-GS-TBLB) is becoming significant approach for diagnosing peripheral pulmonary lesions (PPLs). We aimed to explore the clinical value of resistance pass through lesion in diagnosis PPLs when performing EBUS-GS-TBLB, and determine optimum number EBUS-GS-TBLB.We performed prospective, single-center study 126 consecutive patients who underwent EBUS-GS-TBLB solid positive-bronchus-sign where was located within from September 2019 May 2022. The classification each carried out two bronchoscopists independently, final result depended on bronchoscopist responsible procedures. primary endpoint diagnostic yield according pattern. secondary endpoints were factors affecting yield. Procedural complications also recorded.The total 77.8%, including 83.8% malignant 67.4% benign diseases (P=0.033). Probe type II displayed highest (87.5%), followed III (81.0%) I (61.1%). A difference between detected (P = 0.008), whereas others did not. Although most definitive using or could be diagnosed first biopsy, fourth contributed sufficient samples. In contrast, considerably limited tissue specimens obtained I. inter-observer agreement blinded excellent (κ 0.84).The useful predictive factor successful lesion. Four serial biopsies are appropriate both III, additional procedures needed

Язык: Английский

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Fibre-optic based exploration of lung cancer autofluorescence using spectral fluorescence lifetime

Biomedical Optics Express, Год журнала: 2024, Номер 15(2), С. 1132 - 1132

Опубликована: Янв. 10, 2024

Fibre-optic based time-resolved fluorescence spectroscopy (TRFS) is an advanced technique that generates sample-specific spectral-temporal signature, characterising variations in real-time. As such, it can be used to interrogate tissue autofluorescence. Recent advancements TRFS technology, including the development of devices simultaneously measure high-resolution spectral and temporal fluorescence, paired with novel analysis methods extracting information from these multidimensional measurements effectively, provide additional insight into underlying autofluorescence features a sample. This study demonstrates, using both simulated data endogenous fluorophores measured bench-side, shape lifetime , or lifetimes estimated over channels across broad range, influenced by relative abundance mixed systems their respective environment. study, furthermore, explores properties lung deemed either abnormal normal pathologists. We observe that, on average, at multiple locations sampled 14 tissue, compared shows more variability; and, while not statistically significant, average consistently lower every wavelength than tissue.

Язык: Английский

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