A prediction model for risk of low oxygen saturation in patients with post-tuberculosis tracheobronchial stenosis during bronchoscopy DOI Creative Commons
Hui Chen, Sen Tian, Haidong Huang

et al.

Therapeutic Advances in Respiratory Disease, Journal Year: 2023, Volume and Issue: 17

Published: Jan. 1, 2023

Background: Low oxygen saturation (LOS) is a frequent occurrence for patients with post-tuberculosis tracheobronchial stenosis (PTTS) during bronchoscopic procedures. However, there are currently no systematic assessment tools to predict LOS risk in PTTS bronchoscopy. Objectives: This study aimed develop an effective preoperative predictive model guide clinical practice. Design: Retrospective cohort study. Methods: Data was retrospectively collected from who underwent interventions between January 2017 and December 2022. Among all included this study, 2021 were used as training the logistic regression model, 2022 utilized validation internal validation. We consistency index (C-index), goodness-of-fit test calibration plot evaluate performance. Results: A total of 465 met inclusion criteria enrolled The overall incidence 26.0% (121/465). Comorbidity, degree stenosis, bronchoscopist level, thermal ablation therapy, balloon dilation, airway stenting, independent factors presence LOS, construct nomogram prediction model. C-index 0.827 (95% CI, 0.786–0.869), whereas that 0.836 0.757–0.916), combining results test, demonstrating had good ability. Conclusion: derived ability has been developed preoperatively bronchoscopy, allowing individualized high-risk patients.

Language: Английский

Application of bronchoscopy in the diagnosis and treatment of peripheral pulmonary lesions in China: a national cross-sectional study DOI Creative Commons
Haidong Huang, Ning Wu,

Sen Tian

et al.

Journal of Cancer, Journal Year: 2023, Volume and Issue: 14(8), P. 1398 - 1406

Published: Jan. 1, 2023

Background: Bronchoscopy has gradually become valuable armamentarium in evaluating and applying endoscopic therapy to peripheral pulmonary lesions (PPLs) around the world.We aimed make a comprehensive understanding of application bronchoscopy diagnosis treatment PPLs China.Methods: A cross-sectional survey was carried out China between January 2022 March 2022.The form an online questionnaire which filled with real-time data by respondents.Results: total 347 doctors from 284 tertiary hospitals (81.8%) 63 secondary general (18.2%) were included analysis.More than half surveyed (55.0%) had independently performed respiratory endoscopy for 5-15 years.Higher proportions fixed nursing team, anesthesiologists rapid on-site evaluation (ROSE) during bronchoscopic procedures those (P<0.001each).There 316 (91.7%) eligible performing biopsies less 30mm, while more 300 only 78 (24.7%) per year.Radial probe endobronchial ultrasound (r-EBUS) (50.3%) commonest type technique used guidance bronchoscope PPLs, followed navigational (30.3%) cone beam CT (CBCT) (17.0%).Although two thirds at least one devices, actual utilization these devices not high due capital costs absence training.To note, diagnostic allocated concentrated southeast region coastal cities.Furthermore, therapeutic interventions lung cancer and/or high-risk could be 124 (35.7%) involved hospitals.Conclusions: been most yields different regions varied greatly.To date, few can develop PPLs.

Language: Английский

Citations

11
Transbronchial lung cryobiopsy for peripheral pulmonary lesions. A narrative review DOI Creative Commons
Yibo Tang, Sen Tian, Hua Chen

et al.

Pulmonology, Journal Year: 2023, Volume and Issue: 30(5), P. 475 - 484

Published: Oct. 31, 2023

An increasing number of peripheral pulmonary lesions (PPLs) requiring tissue verification to establish a definite diagnosis for further individualized management are detected due the growing adoption lung cancer screening by chest computed tomography (CT), especially low-dose CT. However, morphological PPLs remains challenging. Transbronchial cryobiopsy (TBLC) that can retrieve larger specimens with more preserved cellular architecture and fewer crush artifacts in comparison conventional transbronchial forceps biopsy (TBFB), as an emerging technology diagnosing PPLs, has been demonstrated have potential resolve clinical dilemma pertaining currently available sampling devices (e.g., forceps, needle brush) become diagnostic cornerstone PPLs. Of note, introduction 1.1 mm cryoprobe will be compatible advanced bronchoscopic navigation techniques, such radial endobronchial ultrasound (r-EBUS), virtual (VBN) electromagnetic bronchoscopy (ENB), use TBLC is expected gain popularity While much exploration using technique it envisaged emergence additional studies data accrual hopefully add body evidence this field.

Language: Английский

Citations

11
Multimodality Imaging with Confocal Endomicroscopy, Red Dichromatic Imaging, and Virtual Bronchoscopic Navigation Guided Recanalization of Complete Airway Obstruction Caused by Tracheobronchial Amyloidosis DOI

Sen Tian,

Yifei Zhang, Shunmin Zhang

et al.

Archivos de Bronconeumología, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
A review on diagnostic assessments of tracheal stenosis DOI Creative Commons
Mojdeh Monjezi, Milad Rismanian, Hamidreza Jamaati

et al.

BioMedical Engineering OnLine, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 14, 2025

Language: Английский

Citations

0
Advancements in Imaging Technologies for the Diagnosis of Lung Cancer and Other Pulmonary Diseases DOI Creative Commons
Alireza Nathani,

H. Erhan Dincer

Diagnostics, Journal Year: 2025, Volume and Issue: 15(7), P. 826 - 826

Published: March 25, 2025

Advancements in imaging technologies have redefined pulmonary medicine, with increased diagnostic accuracy and improved clinical outcomes. This review discusses the evolving landscape of advancements, including pivotal role low-dose computed tomography (CT) lung cancer screening transformative impact endobronchial ultrasound on staging. Imaging techniques like high-resolution CT remain indispensable for diagnosis monitoring parenchymal diseases. Positron emission (PET) is increasingly being used inflammatory conditions sarcoidosis. In pleural diseases, thoracic essential diagnosing performing bedside procedures safely. Advanced modalities ventilation scans also been to target persistent air leaks. emphasizes importance advancements field medicine underscores continued innovation integration these advancements.

Language: Английский

Citations

0
Radial endobronchial ultrasound - guided bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta-analysis of prospective trials DOI Creative Commons

Sen Tian,

Xiang Li,

Jian Liu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29446 - e29446

Published: April 1, 2024

The diagnostic yield of radial endobronchial ultrasound (r-EBUS) for the diagnosis peripheral pulmonary lesions (PPLs) varies between studies and is affected by multiple factors. We aimed to evaluate efficacy safety r-EBUS, explore factors influencing r-EBUS in patients with PPLs.

Language: Английский

Citations

3
Real-time and non-invasive acute lung rejection diagnosis using confocal LASER Endomicroscopy in lung transplant recipients: Results from the CELTICS study DOI Creative Commons
Thomas Villeneuve,

C. Hermant,

A. Le Borgne

et al.

Pulmonology, Journal Year: 2024, Volume and Issue: 31(1)

Published: Feb. 24, 2024

Traditionally, the diagnosis of acute rejection (AR) relies on invasive transbronchial biopsies (TBBs) to obtain histopathological samples. We aimed evaluate diagnostic yield probe-based confocal laser endomicroscopy (pCLE) as a complementary and non-invasive tool for ACR screening, comparing its results with those obtained from TBBs. Between January 2015 April 2022, we conducted retrospective study all lung transplant recipients aged over 18 years at Toulouse University Hospital (France). All patients who underwent bronchoscopies both TBBs pCLE imaging were included. Two experienced interpreters (TV MS) reviewed images independently, blinded clinical information pathology results. From 120 procedures in 85 patients, 34 abnormal histological samples identified. Probe-based revealed significant associations between alveolar (ALC) perivascular (PVC) cellularities (p<0.0001 0.003 respectively). Alveolar cellularity demonstrated sensitivity (Se) 85.3 %, specificity (Spe) 43 positive predictive value (PPV) 37.2 % negative (NPV) 88.1 %. For PVC, Se was 70.6 Spe 80.2 PPV 58.5 NPV 87.3 Intra-interpreter correlation (TV) 88.3 number vessels (+/-1), 98.3 ALC 90 PVC. Inter-interpreter 80 97.5 83.3 Our demonstrates feasibility incorporating into practice, demonstrating good reproducible outcomes screening AR recipients.

Language: Английский

Citations

2
ETV6-NTRK2 Fusion in a Patient With Metastatic Pulmonary Atypical Carcinoid Successfully Treated With Entrectinib: A Case Report and Review of the Literature DOI
Wusheng Zhang, Sen Tian, X. Li

et al.

Clinical Lung Cancer, Journal Year: 2024, Volume and Issue: 25(3), P. 215 - 224.e3

Published: March 19, 2024

Language: Английский

Citations

2
Predictive value of the resistance of the probe to pass through the lesion in the diagnosis of peripheral pulmonary lesions using radial probe endobronchial ultrasound with a guide sheath DOI Creative Commons

Zhenli Hu,

Sen Tian,

Xiangqi Wang

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: July 31, 2023

Transbronchial lung biopsy guided by radial probe endobronchial ultrasonography with a guide sheath (EBUS-GS-TBLB) is becoming significant approach for diagnosing peripheral pulmonary lesions (PPLs). We aimed to explore the clinical value of resistance pass through lesion in diagnosis PPLs when performing EBUS-GS-TBLB, and determine optimum number EBUS-GS-TBLB.We performed prospective, single-center study 126 consecutive patients who underwent EBUS-GS-TBLB solid positive-bronchus-sign where was located within from September 2019 May 2022. The classification each carried out two bronchoscopists independently, final result depended on bronchoscopist responsible procedures. primary endpoint diagnostic yield according pattern. secondary endpoints were factors affecting yield. Procedural complications also recorded.The total 77.8%, including 83.8% malignant 67.4% benign diseases (P=0.033). Probe type II displayed highest (87.5%), followed III (81.0%) I (61.1%). A difference between detected (P = 0.008), whereas others did not. Although most definitive using or could be diagnosed first biopsy, fourth contributed sufficient samples. In contrast, considerably limited tissue specimens obtained I. inter-observer agreement blinded excellent (κ 0.84).The useful predictive factor successful lesion. Four serial biopsies are appropriate both III, additional procedures needed

Language: Английский

Citations

5
Fibre-optic based exploration of lung cancer autofluorescence using spectral fluorescence lifetime DOI Creative Commons
Alexandra Adams, András Kufcsák, Charles Lochenie

et al.

Biomedical Optics Express, Journal Year: 2024, Volume and Issue: 15(2), P. 1132 - 1132

Published: Jan. 10, 2024

Fibre-optic based time-resolved fluorescence spectroscopy (TRFS) is an advanced technique that generates sample-specific spectral-temporal signature, characterising variations in real-time. As such, it can be used to interrogate tissue autofluorescence. Recent advancements TRFS technology, including the development of devices simultaneously measure high-resolution spectral and temporal fluorescence, paired with novel analysis methods extracting information from these multidimensional measurements effectively, provide additional insight into underlying autofluorescence features a sample. This study demonstrates, using both simulated data endogenous fluorophores measured bench-side, shape lifetime , or lifetimes estimated over channels across broad range, influenced by relative abundance mixed systems their respective environment. study, furthermore, explores properties lung deemed either abnormal normal pathologists. We observe that, on average, at multiple locations sampled 14 tissue, compared shows more variability; and, while not statistically significant, average consistently lower every wavelength than tissue.

Language: Английский

Citations

1