Journal of Physics D Applied Physics,
Год журнала:
2012,
Номер
45(26), С. 263001 - 263001
Опубликована: Июнь 13, 2012
Reactive
oxygen
species
(ROS)
and
the
closely
related
reactive
nitrogen
(RNS)
are
often
generated
in
applications
of
atmospheric
pressure
plasmas
intended
for
biomedical
purposes.
These
also
central
players
what
is
sometimes
referred
to
as
'redox'
or
oxidation–reduction
biology.
Oxidation–reduction
biochemistry
fundamental
all
aerobic
ROS
RNS
perhaps
best
known
disease-associated
agents,
implicated
diabetes,
cancer,
heart
lung
disease,
autoimmune
disease
a
host
other
maladies
including
ageing
various
infectious
diseases.
play
active
roles
immune
systems
both
animals
plants
key
signalling
molecules,
among
many
important
roles.
Indeed,
latest
research
has
shown
that
ROS/RNS
much
more
complex
nuanced
role
health
than
previously
thought.
Some
most
potentially
profound
therapeutic
played
by
medical
interventions
have
emerged
only
last
several
years.
Recent
suggests
significant
even
actors
actions
antimicrobial
anti-parasite
drugs,
cancer
therapies,
wound
healing
therapies
involving
cardiovascular
system.
Understanding
ways
act
established
may
help
guide
future
efforts
exploiting
novel
plasma
therapies.
The
importance
plant
biology
been
relatively
little
appreciated
biomedicine
community,
but
these
just
plants.
It
appears
there
opportunities
useful
this
area
well.
Journal of the American College of Cardiology,
Год журнала:
2016,
Номер
68(13), С. 1465 - 1473
Опубликована: Сен. 1, 2016
Coronary
angiography
and
percutaneous
intervention
rely
on
the
use
of
iodinated
intravascular
contrast
for
vessel
chamber
imaging.
Despite
advancements
in
imaging
interventional
techniques,
continues
to
pose
a
risk
contrast-induced
acute
kidney
injury
(CI-AKI)
subgroup
patients
at
this
complication.
There
has
been
consistent
graded
signal
associated
outcomes
including
need
renal
replacement
therapy,
rehospitalization,
death,
according
incidence
severity
CI-AKI.
This
paper
reviews
epidemiology,
pathophysiology,
prognosis,
management
CI-AKI
as
it
applies
cardiac
catheterization
laboratory.
Journal of the American Chemical Society,
Год журнала:
2014,
Номер
136(12), С. 4551 - 4556
Опубликована: Март 5, 2014
Ferrostatin-1
(Fer-1)
inhibits
ferroptosis,
a
form
of
regulated,
oxidative,
nonapoptotic
cell
death.
We
found
that
Fer-1
inhibited
death
in
cellular
models
Huntington's
disease
(HD),
periventricular
leukomalacia
(PVL),
and
kidney
dysfunction;
lipid
peroxidation,
but
not
mitochondrial
reactive
oxygen
species
formation
or
lysosomal
membrane
permeability.
developed
mechanistic
model
to
explain
the
activity
Fer-1,
which
guided
development
ferrostatins
with
improved
properties.
These
studies
suggest
numerous
therapeutic
uses
for
ferrostatins,
peroxidation
mediates
diverse
phenotypes.
Biochemical Journal,
Год журнала:
2011,
Номер
434(3), С. 365 - 381
Опубликована: Фев. 24, 2011
Iron
is
an
essential
but
potentially
hazardous
biometal.
Mammalian
cells
require
sufficient
amounts
of
iron
to
satisfy
metabolic
needs
or
accomplish
specialized
functions.
delivered
tissues
by
circulating
transferrin,
a
transporter
that
captures
released
into
the
plasma
mainly
from
intestinal
enterocytes
reticuloendothelial
macrophages.
The
binding
iron-laden
transferrin
cell-surface
receptor
1
results
in
endocytosis
and
uptake
metal
cargo.
Internalized
transported
mitochondria
for
synthesis
haem
iron–sulfur
clusters,
which
are
integral
parts
several
metalloproteins,
excess
stored
detoxified
cytosolic
ferritin.
metabolism
controlled
at
different
levels
diverse
mechanisms.
present
review
summarizes
basic
concepts
transport,
use
storage
focuses
on
IRE
(iron-responsive
element)/IRP
(iron-regulatory
protein)
system,
well
known
post-transcriptional
regulatory
circuit
not
only
maintains
homoeostasis
various
cell
types,
also
contributes
systemic
balance.
Chemical Society Reviews,
Год журнала:
2010,
Номер
40(1), С. 387 - 426
Опубликована: Авг. 17, 2010
The
study
of
biological
systems
in
a
holistic
manner
(systems
biology)
is
increasingly
being
viewed
as
necessity
to
provide
qualitative
and
quantitative
descriptions
the
emergent
properties
complete
system.
Systems
biology
performs
studies
focussed
on
complex
interactions
system
components;
emphasising
whole
rather
than
individual
parts.
Many
perturbations
mammalian
(diet,
disease,
drugs)
are
multi-factorial
small
parts
insufficient
understand
phenotypic
changes
induced.
Metabolomics
one
functional
level
tool
employed
investigate
metabolites
with
other
(metabolism)
but
also
regulatory
role
through
interaction
genes,
transcripts
proteins
(e.g.
allosteric
regulation).
Technological
developments
driving
force
behind
advances
scientific
knowledge.
Recent
two
analytical
platforms
mass
spectrometry
(MS)
nuclear
magnetic
resonance
(NMR)
spectroscopy
have
driven
forward
discipline
metabolomics.
In
this
critical
review,
an
introduction
metabolites,
metabolomes,
metabolomics
MS
NMR
will
be
provided.
applications
for
health-disease
continuum,
drug
efficacy
toxicity
dietary
effects
health
reviewed.
current
limitations
future
goals
discussed
(374
references).
