International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12111 - 12127
Опубликована: Ноя. 1, 2024
Delayed
healing
and
non-healing
of
bone
defects
pose
significant
challenges
in
clinical
practice,
with
metal
materials
increasingly
recognized
for
their
significance
addressing
these
issues.
Among
materials,
Strontium
(Sr)
Zinc
(Zn)
have
emerged
as
promising
agents
promoting
repair.
Building
upon
this
insight,
research
evaluates
the
impact
a
porous
Sr@Zn@SiO2
nanocomposite
implant
on
regeneration,
aiming
to
advance
field
The
preparation
composite
involves
various
techniques
such
roasting,
centrifugation,
washing.
material's
composition
is
examined,
its
microstructure
element
distribution
are
analyzed
using
TEM
elemental
scanning
technology.
In
vitro
experiments
entail
isolation
characterization
BMSCs
followed
by
safety
assessments
material,
evaluation
cell
migration
capabilities,
relevant
proliferation
markers.
Mechanistically,
study
delves
into
key
targets
associated
changes
osteogenic
process.
vivo
involve
establishing
rat
femur
defect
model,
assessment
potential
Micro-CT
imaging
tissue
section
staining.
Through
investigations,
we
validate
efficacy
implant.
analyses
demonstrate
that
upregulate
BMP-2
expression,
leading
activation
Smad1/5/9
phosphorylation
subsequent
downstream
genes,
culminating
differentiation
proliferation.
And
closely
related
high
expression
CXCL12/CXCR4,
which
will
also
provide
conditions
osteogenesis.
vivo,
ability
was
confirmed
rats.
our
research,
displays
prominent
effect
promotes
promote
healing.
This
bioactive
has
surgical
application
future.
Microvascular
destabilization
is
the
primary
cause
of
inner
blood-retinal
barrier
(iBRB)
breakdown
and
increased
vascular
leakage
in
diabetic
retinopathy
(DR).
results
from
combinational
effects
levels
growth
factors
cytokines,
involvement
inflammation,
changed
cell-to-cell
interactions,
especially
loss
endothelial
cells
pericytes,
due
to
hyperglycemia
hypoxia.
As
manifestation
microvascular
destabilization,
fluid
transports
via
paracellular
transcellular
routes
increase
disruption
intercellular
junctional
complexes
and/or
altered
caveolar
transport
across
retinal
endothelium.
With
diabetes
progression,
functional
structural
changes
iBRB
components,
including
cellular
noncellular
further
facilitate
aggravate
resulting
macular
edema,
neuroretinal
damage
dysfunction
neurovascular
unit
(iNVU).
Although
there
have
been
considerable
recent
advances
towards
a
better
understanding
complex
molecular
network
underlying
some
still
remain
be
fully
elucidated.
Recent
data
indicate
that
targeting
intricate
signaling
pathways
may
allow
against
destabilization.
Therefore,
efforts
made
clarify
mechanisms
are
involved
DR.
In
this
review,
we
discuss:
(1)
brief
introduction
DR
destabilization;
(2)
components
iNVU,
iBRB;
(3)
matrix
contacts
maintain
stabilization,
glycocalyx,
basement
membrane,
various
cell-cell
interactions;
(4)
mediated
cell
death;
(5)
cytokines
as
well
This
comprehensive
review
aimed
provide
insights
for
by
key
molecules
or
specific
cells,
thus
restoring
function
structure
treat
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Ferroptosis,
a
new
type
of
programmed
cell
death
proposed
in
recent
years,
is
characterized
mainly
by
reactive
oxygen
species
and
iron-mediated
lipid
peroxidation
differs
from
death,
such
as
apoptosis,
necrosis,
autophagy.
Ferroptosis
associated
with
variety
physiological
pathophysiological
processes.
Recent
studies
have
shown
that
ferroptosis
can
aggravate
or
reduce
the
occurrence
development
diseases
targeting
metabolic
pathways
signaling
tumors,
ischemic
organ
damage,
other
degenerative
related
to
peroxidation.
Increasing
evidence
suggests
closely
linked
onset
progression
various
ophthalmic
conditions,
including
corneal
injury,
glaucoma,
age-related
macular
degeneration,
diabetic
retinopathy,
retinal
detachment,
retinoblastoma.
Our
review
current
research
on
reveals
significant
advancements
our
understanding
pathogenesis,
aetiology,
treatment
these
conditions.
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 244 - 244
Опубликована: Фев. 20, 2025
Chronic
hyperglycemia
is
a
major
driver
of
neurovascular
damage
in
diabetic
retinopathy
(DR),
leading
cause
preventable
blindness
adults.
DR
progression
often
undetected
until
its
advanced
stages,
with
oxidative
stress
recognized
as
primary
contributor.
In
diabetes,
disrupts
retinal
cellular
balance,
damaging
proteins,
DNA,
and
lipids,
triggering
photoreceptor
degeneration.
Pterostilbene
(Pter),
polyphenol
antioxidant
properties,
has
demonstrated
protective
effects
animal
models
was
assessed
pilot
clinical
study.
patients
treated
250
mg/day
oral
Pter
showed
reduction
the
development
vascular
alterations
characteristic
disease.
Urinary
analyses
confirmed
Pter's
role
reducing
lipid
peroxidation
polyunsaturated
fatty
acids
(PUFAs),
including
arachidonic
adrenic
acids,
indicators
DR.
also
improved
GSH/GSSG
ratio,
reflecting
restored
redox
balance.
However,
after
six
months
without
treatment,
reappeared,
highlighting
importance
sustained
intervention.
These
findings
suggest
that
may
help
slow
by
protecting
against
highlight
implementing
therapies
from
diagnosis
although
long-term
impact
consistent
biomarkers
deserve
more
research
to
optimize
management.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 25, 2025
The
human
retina
is
a
fragile
and
sophisticated
light-sensitive
tissue
in
the
central
nervous
system.
Unhealthy
retinas
can
cause
irreversible
visual
deterioration
permanent
vision
loss.
Effective
therapeutic
strategies
are
restricted
to
treatment
or
reversal
of
these
conditions.
In
recent
years,
nanoscience
nanotechnology
have
revolutionized
targeted
management
retinal
diseases.
Pharmaceuticals,
theranostics,
regenerative
medicine,
gene
therapy,
prostheses
indispensable
for
interventions
been
significantly
advanced
by
nanomedical
innovations.
Hence,
this
review
presents
novel
insights
into
use
versatile
nanomaterial-based
nanocomposites
frontier
applications,
including
non-invasive
drug
delivery,
theranostic
contrast
agents,
nanoagents,
stem
cell-based
optogenetics
prostheses,
which
mainly
reported
within
last
5
years.
Furthermore,
progress,
potential
challenges,
future
perspectives
field
highlighted
discussed
detail,
may
shed
light
on
clinical
translations
ultimately,
benefit
patients
with
disorders.
Jordan Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
18(1), С. 272 - 291
Опубликована: Март 25, 2025
Diabetic
retinopathy
(DR)
is
a
progressive
neurovascular
disorder
due
to
damage
retinal
blood
vessels.
Beta-carotene
acts
as
chromophores
and
initiates
photo-transduction
epithelial
maintenance.
(BC)
present
in
palm
oil
mill
effluent,
it
called
effluent-derived
beta-carotene
(PBC).
The
study
designed
evaluate
the
effect
of
PBC
streptozotocin-induced
DR
zebrafish
by
measuring
oxidative
stress,
inflammation,
polyol
pathway
markers.
five
groups
healthy
Danio
rerio
were
used
this
study.
diabetes
was
instigated
intraperitoneal
administration
streptozotocin
(STZ)
followed
intravitreal
STZ
on
7th
day.
exposure
(50
100
mg/L)
dexamethasone
(DEX)
administered
for
21
continuous
days.
DR-associated
visual
behaviours
i.e.,
optomotor
response
(OMR)
startle
(SR)
appraised
0,
7,
14,
21st
biochemical
changes
plasma
glucose
&
homocysteine
(HCY);
tissue
lipid
peroxidation,
reduced
glutathione
(GSH),
tumor
necrosis
factor-alpha
(TNF-α),
superoxide
dismutase
(SOD)
total
protein
levels
estimated.
lens
evaluation
markers
sorbitol
dehydrogenase
(SDH)
aldose
reductase
(AR)
activity.
potentially
attenuated
with
regulation
abnormalities
which
similar
DEX
treated
group.
Hence,
can
be
management
its
anti-hyperglycemia,
antioxidant,
anti-inflammatory,
regulatory
actions.
