Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Ноя. 8, 2024
Alzheimer's
disease
(AD)
is
the
most
common
human
neurodegenerative
disorder
worldwide.
Owing
to
its
chronic
nature,
our
limited
understanding
of
pathophysiological
mechanisms,
and
because
lack
effective
anti-AD
drugs,
AD
represents
a
significant
socio-economic
challenge
for
all
industrialized
countries.
Neuronal
cell
death
key
factor
in
pathogenesis
recent
studies
have
suggested
that
neuronal
ferroptosis
may
play
major
patho-physiological
role.
Since
involves
free
radical-mediated
lipid
peroxidation,
we
hypothesized
enteral
administration
radical
scavenger
butylated
hydroxytoluene
(BHT)
might
slow
down
or
even
prevent
development
AD-related
symptoms
an
vivo
animal
model.
The
prevalence
of
hyperuricemia
(HUA)
is
climbing
worldwide
and
persistent
elevation
serum
uric
acid
impairs
cognitive
function.
This
study
aimed
to
explore
the
mechanisms
Artemisinin
(Art)
antagonizing
disorder
in
HUA
by
suppressing
pyroptosis.
A
mouse
model
was
established
intraperitoneal
injection
300
mg/kg
potassium
oxonate
(PO)
C57BL/6
mice
for
14
days.
were
simultaneously
treated
with
Art,
an
agonist
pyroptosis
Polyphyllin
VI
(PPVI),
or
glutamate
receptor-interacting
protein
1
(GRIP1)
knockdown
lentiviral
plasmid.
After
treatment,
acid,
IL-6,
TNF-ɑ
levels
examined,
as
well
hippocampal
IL-1β
IL-18
levels,
function
assessed
Morris
water
maze
test.
Pathological
changes
CA1
hippocampus
observed.
Cleave-caspase-1,
GSDMD-N,
GRIP1
level
quantified
western
blot.
PO
induction,
escape
latency
time
spent
target
quadrant
increased
mice,
cell
arrangement
loose
disorganized,
obvious
inflammatory
infiltration
serious
damage
being
observed,
had
elevated
cleaved-caspase-1,
IL-1β,
IL-18.
Art
treatment
reduced
improved
mice.
Administration
PPVI
aggravated
Art-treated
dysfunction
inhibiting
through
upregulation
GRIP1.
blunts
suffering
from
upregulating
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Окт. 10, 2024
Diabetes
mellitus
is
a
metabolic
disorder
with
persistent
hyperglycemia
caused
by
variety
of
underlying
factors.
Chronic
can
lead
to
diverse
serious
consequences
and
diversified
complications,
which
pose
threat
patients.
Among
the
major
complications
are
cardiovascular
disease,
kidney
diabetic
foot
ulcers,
retinopathy,
neurological
disorders.
Heme
oxygenase
1
(HO-1)
protective
enzyme
antioxidant,
anti-inflammatory
anti-apoptotic
effects,
has
been
intensively
studied
plays
an
important
role
in
complications.
By
inducing
expression
activity
HO-1,
it
enhance
anti-inflammatory,
capacity
tissues,
thus
reduce
degree
damage
The
present
study
aims
review
relationship
between
HO-1
pathogenesis
diabetes
its
involved
regulation
macrophage
polarization
promotes
M1
state
(pro-inflammatory)
towards
M2
(anti-inflammatory).
Induction
dendritic
cells
inhibits
them
maturation
secretion
pro-inflammatory
cytokines
regulatory
T
cell
(T
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8126 - 8126
Опубликована: Июль 25, 2024
Diabetic
neuropathy
(DN)
is
a
common
complication
of
diabetes,
affecting
over
50%
patients,
leading
to
significant
pain
and
burden.
Currently,
there
are
no
effective
treatments
available.
Cell
death
considered
key
factor
in
promoting
the
progression
DN.
This
article
reviews
how
cell
initiated
DN,
emphasizing
critical
roles
oxidative
stress,
mitochondrial
dysfunction,
inflammation,
endoplasmic
reticulum
autophagy.
Additionally,
we
thoroughly
summarize
mechanisms
that
may
be
involved
pathogenesis
including
apoptosis,
autophagy,
pyroptosis,
ferroptosis,
among
others,
as
well
potential
therapeutic
targets
offered
by
these
mechanisms.
provides
pathways
for
prevention
treatment
diabetic
future.
The American Journal of Chinese Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Сен. 30, 2024
Artemisinin
(ART)
and
its
derivatives,
collectively
referred
to
as
artemisinins
(ARTs),
have
been
approved
for
the
treatment
of
malaria
decades.
ARTs
are
converted
into
dihydroartemisinin
(DHA),
only
active
form,
which
is
reductive
in
vivo.
In
this
review,
we
provide
a
brief
overview
neuroprotective
potential
underlying
mechanisms
on
several
most
common
neurodegenerative
diseases,
particularly
considering
their
application
those
associated
with
cognitive
motor
impairments
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
Huntington’s
(HD),
amyotrophic
lateral
sclerosis
(ALS).
act
autophagy
balancers
alleviate
AD
PD.
They
inhibit
neuroinflammatory
responses
by
regulating
phosphorylation
signal
transduction
proteins,
such
AKT,
PI3K,
ERK,
NF-[Formula:
see
text]B,
p38
MAPK,
I[Formula:
text]B[Formula:
text].
addition,
regulate
GABAergic
signaling
dose-dependent
manner.
Although
they
competitively
binding
gephyrin
receptors,
low
doses
enhance
signaling.
can
also
ferroptosis,
activate
Akt/Bcl-2,
AMPK,
or
ERK/CREB
pathways
reduce
oxidative
stress,
maintain
mitochondrial
homeostasis,
protecting
neurons
from
stress
injury.
More
importantly,
structurally
combine
suppress
[Formula:
text]-Amyloid
(A[Formula:
text]-induced
neurotoxicity,
P-tau,
O-GlcNAcylation/Phosphorylation
balance,
leading
relieved
pathological
changes
diseases.
Collectively,
these
natural
properties
endow
unique
