Remodeling of tumour microenvironment: strategies to overcome therapeutic resistance and innovate immunoengineering in triple-negative breast cancer DOI Creative Commons
Desh Deepak Singh, Shafiul Haque, Youngsun Kim

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Triple-negative breast cancer (TNBC) stands as the most complex and daunting subtype of affecting women globally. Regrettably, treatment options for TNBC remain limited due to its clinical complexity. However, immunotherapy has emerged a promising avenue, showing success in developing effective therapies advanced cases improving patient outcomes. Improving treatments involves reducing side effects, minimizing systemic toxicity, enhancing efficacy. Unlike traditional immunotherapy, engineered nonmaterial's can precisely target TNBC, facilitating immune cell access, antigen presentation, triggering lasting responses. Nanocarriers with enhanced sensitivity specificity, specific cellular absorption, low toxicity are gaining attention. Nanotechnology-driven immunoengineering strategies focus on targeted delivery systems using multifunctional molecules precise tracking, diagnosis, therapy TNBC. This study delves into TNBC's tumour microenvironment (TME) remodeling, therapeutic resistance, nanotechnology.

Language: Английский

Emerging Applications of Nanoparticles in the Diagnosis and Treatment of Breast Cancer DOI Open Access

Josephine B Oehler,

Weranga Rajapaksha, Hugo Albrecht

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 723 - 723

Published: July 4, 2024

Breast cancer remains the most prevalent among women worldwide, driving urgent need for innovative approaches to diagnosis and treatment. This review highlights pivotal role of nanoparticles in revolutionizing breast management through advancements interconnected including targeted therapy, imaging, personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise addressing current treatment limitations such as drug resistance nonspecific systemic distribution. Applications range from enhancing delivery systems sustained release developing diagnostic tools early precise detection metastases. Moreover, integration into photothermal therapy synergistic use existing treatments, immunotherapy, illustrate transformative potential care. However, journey towards clinical adoption is fraught challenges, chemical feasibility, biodistribution, efficacy, safety concerns, scalability, regulatory hurdles. delves state nanoparticle research, applications diagnosis, obstacles that must be overcome integration.

Language: Английский

Citations

21
Antitumor Research Based on Drug Delivery Carriers: Reversing the Polarization of Tumor-Associated Macrophages DOI
Xinyu Cao,

Shen Wan,

Bingyu Wu

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The development of malignant tumors is a complex process that involves the tumor microenvironment (TME). An immunosuppressive TME presents significant challenges to current cancer therapies, serving as key mechanism through which cells evade immune detection and play crucial role in progression metastasis. This impedes optimal effectiveness immunotherapeutic approaches, including cytokines, checkpoint inhibitors, vaccines. Tumor-associated macrophages (TAMs), major component tumor-infiltrating cells, exhibit dual functionalities: M1-like TAMs suppress tumorigenesis, while M2-like promote growth Consequently, various nanocarriers aimed at polarizing phenotypes distinct mechanisms has emerged promising therapeutic strategy inhibit escape enhance antitumor responses. Review covers origin types TAMs, common pathways regulating macrophage polarization, progression, strategies targeting aiming provide comprehensive understanding guidance for future research clinical applications.

Language: Английский

Citations

1
CD-44 targeted nanoparticles for combination therapy in an in vitro model of triple-negative breast cancer: targeting the tumour inside out DOI Creative Commons
Silvia Gómez-Pastor,

Auréane Maugard,

Harriet R. Walker

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114504 - 114504

Published: Jan. 9, 2025

Triple-negative breast cancer (TNBC) is an aggressive form of defined by the lack three key receptors: estrogen, progesterone, and HER2. This receptors makes TNBC difficult to treat with hormone therapy or drugs, so it characterised a poor prognosis compared other kinds cancer. study explores photoactive Poly(lactic-co-glycolic acid) (PLGA) nanoparticles as potential therapeutic strategy for TNBC. The are functionalised hyaluronic acid (HA) targeted delivery CD-44 overexpressed in cells, especially under hypoxic conditions. Additionally, we co-loaded Doxorubicin (Dox) Indocyanine Green (ICG) enable combinatorial chemo-photothermal therapy. After carefully optimising formulation, propose effortless reproducible preparation nanodrugs. We demonstrate that HA-conjugated effectively target cells inhibit their proliferation while treatment efficiency enhanced during near-infrared light irradiation. also prove our effective 3D cell culture model, highlighting importance tumour architecture metabolic stage microenvironment. approach promising tumour-targeted theragnostic improved efficacy microenvironments.

Language: Английский

Citations

0
Advances in Cancer Research through Functionalized Silk Fibroin Nanomaterial Drug Delivery Systems DOI Creative Commons

Yuhua Han,

Wenli Li,

Jie Zhao

et al.

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 126, P. 136 - 141

Published: Jan. 10, 2025

With the continuous development of medical and materials science technologies, drug delivery have started transitioning from synthetic to natural materials. Silk fibroin, known for its excellent biocompatibility drug-loading capabilities, has shown immense potential broad prospects in enhancing cellular uptake rates tumor tissue aggregation through construction nanomaterial systems, thereby improving resistance issues increasing efficiency cancer treatment. This paper summarizes application functionalized silk fibroin nanomaterials field delivery, based on relevant domestic international research. It aims provide a reference further in-depth research this area.

Language: Английский

Citations

0
Green synthesis of silver nanoparticles coated with Methotrexate-conjugated Polyvinyl Alcohol: as potential nanosystem for chemo/radiotherapy DOI

Nazli Aghapur,

Mahmoud Gharbavi, Zahra Bigdelou

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106643 - 106643

Published: Jan. 1, 2025

Language: Английский

Citations

0
An update on cancer stem cell survival pathways involved in chemoresistance in triple-negative breast cancer DOI
Asma Jan,

Shazia Sofi,

Nusrat Jan

et al.

Future Oncology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: Feb. 12, 2025

Triple-negative breast cancer (TNBC) presents a formidable global health challenge, marked by its aggressive behavior and significant treatment resistance. This subtype, devoid of estrogen, progesterone, HER2 receptors, largely relies on stem cells (BCSCs) for progression, metastasis, recurrence. BCSCs, characterized their self-renewal capacity resistance to conventional therapies, exploit key surface markers critical signaling pathways like Wnt, Hedgehog, Notch, TGF-β, PI3K/AKT/mTOR Hippo-YAP/TAZ thrive. Their adaptability is underscored mechanisms including drug efflux enhanced DNA repair, contributing poor prognosis high recurrence rates. The tumor microenvironment (TME) further facilitates BCSC survival through complex interactions with stromal immune cells. Emerging therapeutic strategies targeting BCSCs - ranging from immunotherapy nanoparticle-based delivery systems gene-editing technologies aim disrupt these resistant Additionally, innovative approaches focusing exosome-mediated metabolic reprogramming show promise in overcoming chemoresistance. By elucidating the distinct characteristics role TNBC, researchers are paving way novel treatments that may effectively eradicate resilient cells, mitigate ultimately improve patient outcomes. review highlights urgent need targeted address unique biology pursuit more effective interventions TNBC.

Language: Английский

Citations

0
Silencing of fibronectin type III domain-containing protein 3A (FNDC3A) attenuates epithelial-to-mesenchymal transition (EMT), cancer invasion, and stemness in triple-negative breast cancer (TNBC) DOI
Noriaki Wada, Satoshi Sakai, Yasumichi Inoue

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 119935 - 119935

Published: March 1, 2025

Language: Английский

Citations

0
Composites of Reduced Graphene Oxide Based on Silver Nanoparticles and Their Effect on Breast Cancer Stem Cells DOI Creative Commons

Babu Vimalanathan,

Devasena Thiyagarajan,

Ruby Nirmala Mary

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 508 - 508

Published: May 11, 2025

Graphene and its related nanocomposites have garnered significant interest due to their distinct physiochemical biological properties. In this study, reduced graphene oxide–silver hybrid nanostructures were synthesized for applications in biomedical nanotechnology, particularly targeting cancer stem cells (CSCs). A range of analytical techniques, such as X-ray diffraction (XRD), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), UV–visible absorption (UV–VIS), employed characterize oxide (GO), (rGO)–silver nanoparticles (AgNPs), composite structures. The GO-rGO-AgNPs exhibited potent anticancer properties evidenced by cell culture assays, spheroid formation assay, quantitative RT-PCR analysis. Treatment breast (MCF-7) with GO, rGO, AgNPs significantly proliferation mammosphere formation. Furthermore, these treatments downregulated the expression marker genes associated CSCs MCF-7 cells. Among tested materials, rGO-AgNP, sodium citrate-mediated GO-AgNP, rGO-AgNP demonstrated superior inhibitory effects on survival compared GO alone. These findings suggest that hold promise effective non-toxic therapeutic agents CSCs, thereby offering a novel approach treatment.

Language: Английский

Citations

0
Targeting tumor-associated macrophages with nanocarrier-based treatment for breast cancer: A step toward developing innovative anti-cancer therapeutics DOI Creative Commons
Ghazala Muteeb, Doaa S. R. Khafaga,

Manar T El-Morsy

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37217 - e37217

Published: Aug. 30, 2024

Language: Английский

Citations

3
Navigating the therapeutic landscape for breast cancer: targeting breast cancer stem cells DOI

S. Chatti Dey,

Yirivinti Hayagreeva Dinakar,

R. Soundarya

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

Citations

3