Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments

Molecular Neurobiology, Год журнала: 2024, Номер 61(9), С. 6469 - 6483

Опубликована: Фев. 3, 2024

Язык: Английский

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Bridging the gap: associations between gut microbiota and psychiatric disorders

Middle East Current Psychiatry, Год журнала: 2024, Номер 31(1)

Опубликована: Янв. 15, 2024

Abstract Background Gut microbiota plays a pivotal role in the gut-brain axis and can influence neurodevelopment mental health outcomes. This review summarizes current evidence on associations between gut alterations various psychiatric illnesses. Main body The composition of microbiome evolves from birth through old age, disruptions during critical periods may increase disease risk. Factors like diet, medications, stress, infections disturb microenvironment lead to dysbiosis. Dysbiosis has been linked conditions depression, anxiety, autism, ADHD, schizophrenia. Proposed mechanisms involve microbial regulation neurotransmitters, inflammation, oxidative blood-brain barrier permeability, immune system. Therapeutic strategies probiotics, prebiotics, faecal transplantation modulate ecosystem. However, more research is needed elucidate causal microbiota-psychiatry relationship. Understanding interactions uncover new possibilities for preventing managing disorders. Conclusion A growing points close relationship health. While field still emerging, dysbiosis ecosystem associated with neuropsychiatric conditions. underlying likely microbiota-gut-brain signalling pathways. Additional larger samples required establish links specific changes

Язык: Английский

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Aspects of Area Deprivation Index in Relation to Hippocampal Volume Among Children

JAMA Network Open, Год журнала: 2024, Номер 7(6), С. e2416484 - e2416484

Опубликована: Июнь 12, 2024

Area deprivation index (ADI) has been shown to be associated with reduced hippocampal volume (HV) among youths. The social environment may interact the association between ADI and HV.

Язык: Английский

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Early‐Life Adversity Predicts Markers of Aging‐Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women

Annals of Neurology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Objective Despite the overwhelming evidence for profound and longstanding effects of early‐life stress (ELS) on inflammation, brain structure, molecular aging, its impact human aging risk neurodegenerative disease is poorly understood. We examined ELS severity in interaction with age blood‐based markers neuroinflammation neurodegeneration, volumes, cognitive function middle‐aged women. Methods recruited 179 women (aged 30–60 years) without exposure before onset puberty. Using Simoa technology, we assessed including serum concentrations glial fibrillary acidic protein (GFAP) neurofilament light chain (NfL). further obtained T1‐weighted T2‐weighted magnetic resonance images to assess volumes performance sensitive early impairments associated development dementia, using Cambridge Neuropsychological Automated Test Battery. used generalized additive models examine nonlinear these outcomes. Results Analyses revealed significant NfL GFAP concentrations, total subcortical gray matter volume loss, increased third ventricular volume, impairment. Interpretation These findings suggest that profoundly exacerbates peripheral, neurostructural, aging. Our results are critical novel prevention strategies target developmental mitigate aging‐related neurological diseases. ANN NEUROL 2025

Язык: Английский

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Association of parental rearing styles with suicidal ideation in Chinese adolescent patients with depression: a large-scale cross-sectional study

Frontiers in Psychiatry, Год журнала: 2025, Номер 15

Опубликована: Янв. 9, 2025

Suicide is the first cause of death among adolescents globally and has a severe impact on socioeconomic development. Several studies have found that suicide attempts suicidal ideation (SI) are more likely to occur in with depression. Previous stressful events early childhood, especially family stress, can influence occurrence SI. Chinese parents tend be strict less able express their emotions, owing unique national conditions, which may result parenting problems. Therefore, our study investigates risk factors for SI large sample A total 1604 adolescent patients depression were recruited this study. self-administered questionnaire collected clinical demographic data. was assessed by interview. The Egna Minnen Beträffande Uppfostran (EMBU) scale used evaluate parental rearing style. showed female (OR=1.886, 95%CI:1.502-2.368), sleep (OR=0.798, 95%CI:0.637-0.998), school management (OR=1.179, 95%CI:1.041-1.336), alcohol consumption (OR=1.798, 95%CI:1.304-2.479), child life (OR=1.797, 95%CI:1.457-2.216), maternal interference (OR=1.032, 95%CI:1.015-1.048), paternal emotional warmth (OR=0.975, 95%CI:0.966-0.983) rejection (OR=1.102, 95%CI:1.063-1.142) significantly associated To recognize earlier, physicians nurses need pay attention those populations experiencing an unhappy non-democratic management, consumption, excessive interference, lack warmth, rejection.

Язык: Английский

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The Mental Health of Minority and Marginalized Young People: An Opportunity for Action

Public Health Reports, Год журнала: 2022, Номер 137(4), С. 613 - 616

Опубликована: Июнь 8, 2022

Язык: Английский

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The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

Nutrients, Год журнала: 2022, Номер 14(5), С. 1107 - 1107

Опубликована: Март 6, 2022

Major depressive disorder (MDD) is an incapacitating condition characterized by loss of interest, anhedonia and low mood, which affects almost 4% people worldwide. With rising prevalence, it considered a public health issue that economic productivity heavily increases costs alone or as comorbidity for other pandemic non-communicable diseases (such obesity, cardiovascular disease, diabetes, inflammatory bowel diseases, etc.). What even more noteworthy the double number women suffering from MDD compared to men. In fact, this sex-related ratio has been contemplated since men have different sexual hormone oscillations, where meet significant changes depending on age range moment life (menstruation, premenstruation, pregnancy, postpartum, menopause…), seem be associated with susceptibility symptoms. For instance, decreased estrogen level promotes activation serotonin transporters. Nevertheless, hormones are not only triggers alter neurotransmission monoamines neuropeptides. Actually, dietary habits and/or nutritional requirements specific moments severely affect pathophysiology in women. context, present review aims descriptively collect information regarding role malnutrition onset course, focusing female patient especially macro- micronutrient deficiencies (amino acids, ω3 polyunsaturated fatty acids (ω3 PUFAs), folate, vitamin B12, D, minerals…), besides providing evidence future intervention programs sex-gender perspective hopefully improves mental quality

Язык: Английский

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Developmental psychopathology

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 206 - 220

Опубликована: Янв. 1, 2024

Язык: Английский

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Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms

Biomedicines, Год журнала: 2024, Номер 12(9), С. 1978 - 1978

Опубликована: Сен. 2, 2024

Stress profoundly affects physical and mental health, particularly when experienced early in life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse, neglect, violence, or chronic poverty. These stressors can induce long-lasting changes brain structure function, impacting areas involved emotion regulation, cognition, response. Consequently, individuals exposed to high levels of ELS are at an increased risk for health disorders like depression, anxiety, post-traumatic disorders, well issues, including metabolic cardiovascular disease, cancer. This review explores the biological psychological consequences early-life adversity paradigms rodents, maternal separation deprivation limited bedding nesting. The study these experimental models have revealed that organism’s response is complex, involving genetic epigenetic mechanisms, associated with dysregulation physiological systems nervous, neuroendocrine, immune systems, a sex-dependent fashion. Understanding impact crucial developing effective interventions preventive strategies humans stressful traumatic childhood.

Язык: Английский

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Exposure to traffic-related air pollution and noise during pregnancy and childhood, and functional brain connectivity in preadolescents

Environment International, Год журнала: 2022, Номер 164, С. 107275 - 107275

Опубликована: Май 5, 2022

The amount of people affected by traffic-related air pollution and noise is continuously increasing, but limited research has been conducted on the association between these environmental exposures functional brain connectivity in children. This exploratory study aimed to analyze associations exposure during pregnancy childhood, amongst a wide-swath areas preadolescents from 9 12 years age. We used data 2,197 children Generation R Study. Land use regression models were applied estimate nitrogen oxides particulate matter levels at participant's homes for several time periods: pregnancy, birth 3 years, 6 age magnetic resonance imaging (MRI) assessment. Existing maps road traffic same periods. Resting-state MRI was obtained 9–12 Pair-wise correlation coefficients blood-oxygen-level-dependent signals 380 calculated. Linear regressions run corrected multiple testing. Preadolescents exposed higher NO2, NOx, PM2.5 absorbance, showed among regions (e.g. 0.16 0.19 coefficient related absorbance exposure, depending connection). Overall, most identified task positive negative networks, mainly inter-network (20 26). Slightly more than half connections intra-hemispheric (14 26), predominantly right hemisphere. Road not associated with connectivity. found that first life located These results could be an indicator differential pollution.

Язык: Английский

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