Biomolecules,
Год журнала:
2024,
Номер
14(5), С. 554 - 554
Опубликована: Май 4, 2024
Osteoporosis
(OP),
a
prevalent
skeletal
disorder
characterized
by
compromised
bone
strength
and
increased
susceptibility
to
fractures,
poses
significant
public
health
concern.
This
review
aims
provide
comprehensive
analysis
of
the
current
state
research
in
field,
focusing
on
application
proteomic
techniques
elucidate
diagnostic
markers
therapeutic
targets
for
OP.
The
integration
cutting-edge
technologies
has
enabled
identification
quantification
proteins
associated
with
metabolism,
leading
deeper
understanding
molecular
mechanisms
underlying
In
this
review,
we
systematically
examine
recent
advancements
studies
related
OP,
emphasizing
potential
biomarkers
OP
diagnosis
discovery
novel
targets.
Additionally,
discuss
challenges
future
directions
highlighting
impact
transforming
landscape
treatment.
Mass Spectrometry Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
ABSTRACT
Cancer
is
the
leading
cause
of
death
worldwide
characterized
by
patient
heterogeneity
and
complex
tumor
microenvironment.
While
genomics‐based
testing
has
transformed
modern
medicine,
challenge
diverse
clinical
outcomes
highlights
unmet
needs
for
precision
oncology.
As
functional
molecules
regulating
cellular
processes,
proteins
hold
great
promise
as
biomarkers
drug
targets.
Mass
spectrometry
(MS)‐based
proteomics
illuminated
molecular
features
cancers
facilitated
discovery
or
therapeutic
targets,
paving
way
innovative
strategies
that
enhance
personalized
treatment.
In
this
article,
we
introduced
tools
current
achievements
MS‐based
proteomics,
choice
targeted
MS
from
to
validation
phases,
profiling
sensitivity
bulk
samples
single‐cell
level
tissue
liquid
biopsy
specimens,
regulatory
landscape
protein
laboratory‐developed
tests
(LDTs).
The
challenges,
success
future
perspectives
in
translating
research
assay
into
applications
are
also
discussed.
With
well‐designed
studies
demonstrate
benefits
meet
requirements
both
analytical
performance,
assays
promising
with
numerous
opportunities
improve
cancer
diagnosis,
treatment,
monitoring.
Osteoporosis
(OP),
a
prevalent
skeletal
disorder
characterized
by
compromised
bone
strength
and
increased
susceptibility
to
fractures,
poses
significant
public
health
concern.
This
review
aims
provide
comprehensive
analysis
of
the
current
state
research
in
field,
focusing
on
application
proteomic
techniques
elucidate
diagnostic
markers
therapeutic
targets
for
OP.
The
integration
cutting-edge
technologies
has
enabled
identification
quantification
proteins
associated
with
metabolism,
leading
deeper
understanding
molecular
mechanisms
underlying
In
this
review,
we
systematically
examine
recent
advancements
studies
related
OP,
emphasizing
potential
biomarkers
OP
diagnosis
discovery
novel
targets.
Additionally,
discuss
challenges
future
directions
highlighting
impact
transforming
landscape
treatment.
Biomolecules,
Год журнала:
2024,
Номер
14(5), С. 554 - 554
Опубликована: Май 4, 2024
Osteoporosis
(OP),
a
prevalent
skeletal
disorder
characterized
by
compromised
bone
strength
and
increased
susceptibility
to
fractures,
poses
significant
public
health
concern.
This
review
aims
provide
comprehensive
analysis
of
the
current
state
research
in
field,
focusing
on
application
proteomic
techniques
elucidate
diagnostic
markers
therapeutic
targets
for
OP.
The
integration
cutting-edge
technologies
has
enabled
identification
quantification
proteins
associated
with
metabolism,
leading
deeper
understanding
molecular
mechanisms
underlying
In
this
review,
we
systematically
examine
recent
advancements
studies
related
OP,
emphasizing
potential
biomarkers
OP
diagnosis
discovery
novel
targets.
Additionally,
discuss
challenges
future
directions
highlighting
impact
transforming
landscape
treatment.
