Research Square (Research Square),
Год журнала:
2021,
Номер
unknown
Опубликована: Ноя. 2, 2021
Abstract
Cephalosporin
antibiotics,
a
group
of
widely
prescribed
are
frequently
detected
in
wastewater
effluent
and
the
natural
aquatic
environment.
Materials
have
been
sought
to
effectively
degrade
antibiotics.
In
this
study,
novel
high-iron
clay
was
prepared
with
potassium
ferrate
montmorillonite
via
strong
alkaline
in-situ
synthesis
method.
Degradation
cefazolin
sodium
(CFZ)
by
Fe
(VI)-clay
investigated.
The
optimal
conditions
for
degradation
CFZ
were
determined
using
single
factor
experiment
response
surface
optimization
We
found
that
89.84
%
removal
efficiency
obtained
137
min
when
pH
value
5.16
dosage
0.79
g/100mL.
mechanism
studied
Density
Functional
Theory
(DFT)
combination
spectroscopic
mass
analysis.
characteristics
products
at
different
stages
showed
oxidation
decomposition
reaction
occurred
during
Fe(VI)
-clay.
Further,
DFT
calculation
combined
GC-MS
results
pathways
mainly
cleavage
β-lactam,
thiadiazole,
tetrazole
dihydrothiazine
rings.
Journal of Hazardous Materials,
Год журнала:
2022,
Номер
429, С. 128302 - 128302
Опубликована: Янв. 20, 2022
Concerns
about
environmental
contamination
by
organic
micropollutants
(OMPs)
are
increasing,
due
to
their
potential
bioaccumulative
and
toxic
properties.
This
study
evaluated
the
risk
posed
OMPs
aquatic
ecosystems
in
Swedish
freshwaters.
The
assessment
was
based
on
measured
concentrations
(MEC)
of
surface
waters
upstream
downstream
wastewater
treatment
plants
(WWTPs).
A
novel
optimised
quotient
(RQf)
used
identify
high-risk
substances
environment.
secondary
objective
assess
impact
WWTP
effluent
using
a
factor
(I)
(RQ).
Among
126
investigated,
four
compounds
(metformin,
N,N-dimethyltetradecylamine,
oxazepam,
venlafaxine)
were
identified
as
likely
pose
(RQf>1),
five
(clindamycin,
gemfibrozil,
sertraline,
o-desmethylvenlafaxine,
diclofenac)
posing
moderate
(
0.1
Water Research,
Год журнала:
2022,
Номер
222, С. 118878 - 118878
Опубликована: Июль 18, 2022
This
study
aimed
to
provide
insights
into
the
risk
posed
by
psychopharmaceuticals
and
illicit
drugs
in
European
surface
waters,
identify
current
knowledge
gaps
hampering
this
assessment.
First,
availability
quality
of
data
on
concentrations
waters
(occurrence)
toxicity
aquatic
organisms
(hazard)
were
reviewed.
If
both
occurrence
ecotoxicity
available,
quotients
(risk)
calculated.
Where
abundant
a
species
sensitivity
distribution
(SSD)
was
constructed,
from
which
hazardous
concentration
for
5%
(HC5)
derived,
allowing
derive
integrated
multi-species
risks.
A
total
702
compounds
categorised
as
based
combination
all
502
anatomical
therapeutic
class
(ATC)
'N'
pharmaceuticals
list
according
Dutch
Opium
Act.
Of
these,
343
(49%)
returned
data,
while
only
105
(15%)
data.
Moreover,
many
tests
used
irrelevant
endpoints
neurologically
active
compounds,
such
mortality,
may
underestimate
hazard
psychopharmaceuticals.
Due
limitations,
risks
could
be
assessed
87
(12%)
with
23
(3.3%)
indicating
potential
risk,
several
highly
prescribed
neither
nor
Primary
bottlenecks
calculation
included
lack
diversity
test
ecotoxicological
end
points,
large
disparities
between
well
studied
understudied
identified
merit
concern,
that
any
driving
research
priorities.
Despite
gaps,
we
concluded
presence
substantial
part
(26%)
data-rich
present
an
ecological
non-target
organisms.
The Science of The Total Environment,
Год журнала:
2023,
Номер
906, С. 167440 - 167440
Опубликована: Сен. 28, 2023
Reducing
the
risk
posed
by
mixtures
of
pharmaceuticals
is
a
goal
current
initiatives
such
as
European
Green
Deal
to
reduce
anthropological
environmental
impacts.
Wastewater
effluent
typically
contains
large
numbers
active
pharmaceutical
ingredients
(APIs).
For
some
APIs,
existing
technology
conventional
activated
sludge
(CAS)
wastewater
treatment
plants
(WWTPs)
have
removal
rates
below
20
%,
thus
WWTP
discharges
are
adding
toxic
burden
receiving
waters.
We
present
an
assessment
35
APIs
in
samples
from
82
Northern
WWTPs
using
concentration
addition
model,
and
identify
respective
risk-driving
APIs.
This
then
compared
corresponding
mixture
Danish
Hillerød
subjected
post-treatment
with
varying
specific
ozone
doses
(0.15-1.05
mgO3/mgDOC)
and/or
granulated
carbon
(GAC).
All
exceeded
thresholds
at
least
factor
30,
median
RQSUM
92.9,
highlighting
need
for
substantial
dilution
recipient
Antibiotics,
analgesics
anti-depressants
were
among
top
drivers
99
%
average
attributable
azithromycin,
diclofenac,
venlafaxine,
clarithromycin
mycophenolic
acid.
Effluent
was
reduced
ozonation
concentration-dependent
manner,
decreasing
threshold
levels
0.83
following
0.65
mgO3/mg
DOC.
Fresh
GAC
also
effective
reducing
both
alone
treatment,
0.04
0.07
respectively.
To
our
knowledge,
this
first
study
comparing
"conventional"
processes
additional
joint
risks
demonstrate
technologies,
efficacy
aquatic
environment
acceptable
limits.
European Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
192, С. 106614 - 106614
Опубликована: Окт. 17, 2023
Active
pharmaceutical
ingredients
(APIs),
their
metabolites
and
transformation
products
(TPs)
are
found
as
pollutants
in
the
environment.
They
can
impact
human
environmental
health.
To
address
this
issue,
an
efficient,
long-term
prevention
strategy
could
be
design
of
APIs
that
have
less
on
natural
environment,
i.e.
greener
APIs,
by
implementation
parameters
into
drug
discovery
development
process
(also
abbreviated
R&D
for
'research
development').
Our
study
aimed
to
evaluate
feasibility
based
insights
from
experts
working
large,
research-based
companies.
The
evaluation
also
identified
needs
incentives
modification.
For
purpose,
30
seven
globally
active
companies
were
interviewed
along
a
structured
questionnaire.
Main
findings
saw
manifold
opportunities
include
properties
rendering
different
stages
process.
This
would
favoured
fact
is
very
flexible
relies
balancing
multiple
parameters.
Furthermore,
some
API
reduce
risks
considered
compatible
with
common
desirable
application.
Environmental
should
early
during
R&D,
when
molecules
screened
optimized.
It
has
been
availability
suitable
silico
models
vitro
assays
crucial
consideration.
Their
attributes,
e.g.
throughput
costs,
determine
at
which
stage
they
successfully
applied.
An
intensified
exchange
between
within
outside
push
industrial
application
benign
approach
forward.
Collaboration
across
companies,
authorities,
academia
seen
highly
promising
respect.
Financial,
social,
regulatory
support
future
APIs.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
266, С. 131168 - 131168
Опубликована: Март 27, 2024
Pharmaceuticals,
designed
for
treating
diseases,
ironically
endanger
humans
and
aquatic
ecosystems
as
pollutants.
Adsorption-based
wastewater
treatment
could
address
this
problem,
however,
creating
efficient
adsorbents
remains
a
challenge.
Recent
efforts
have
shifted
towards
sustainable
bio-based
adsorbents.
Here,
cryogels
from
lignin-containing
cellulose
nanofibrils
(LCNF)
lignin
nanoparticles
(LNPs)
were
explored
pharmaceuticals
An
enzyme-based
approach
using
laccase
was
used
crosslinking
instead
of
fossil-based
chemical
modification.
The
impact
on
LNPs
alone
produced
surface-crosslinked
water-insoluble
with
preserved
morphology
hemicellulose-rich,
water-soluble
LNP
fraction.
displayed
significant
increase
in
adsorption
capacity,
up
to
140
%
400
neutral
cationic
drugs,
respectively.
crosslinked
cryogel
prepared
by
one-pot
incubation
LNPs,
LCNF
showed
significantly
higher
capacities
various
multi-component
system
than
pure
or
unmodified
cryogels.
minimized
the
leaching
water,
signifying
enhanced
binding
between
LCNF.
In
real
wastewater,
laccase-modified
8–47
removal
pharmaceuticals.
Overall,
facilitated
production
improving
deposition
Finally,
work
introduces
engineering
adsorbents,
while
aligning
global
sustainability
goals.
