Sex Differences in Characteristics Associated with Potentially Inappropriate Medication Use and Associations with Functional Capacity in Older Participants of the Berlin Aging Study II

Gerontology, Год журнала: 2021, Номер 68(6), С. 664 - 672

Опубликована: Сен. 17, 2021

<b><i>Introduction:</i></b> Medication safety is a vital aim in older adults’ pharmacotherapy. Increased morbidity and vulnerability require particularly careful prescribing. Beneath avoiding unnecessary polypharmacy prescribing omissions, physicians have to be aware of potentially inappropriate medications (PIMs) related outcomes optimize drug therapy, reduce adverse events. <b><i>Objective:</i></b> The this study was identify participants characteristics associated with PIM use associations functional capacity focus on sex differences. <b><i>Methods:</i></b> Multivariable logistic regression analyses cross-sectional Berlin Aging Study II (BASE-II) data (<i>N</i> = 1,382, median age 69 years, interquartile range 67–71, 51.3% women) were performed classification according the EU(7)-PIM list. <b><i>Results:</i></b> In overall population, higher education lower odds (odds ratio [OR] 0.93, confidence interval [CI] 95% 0.87–0.99, <i>p</i> 0.017). Falls (OR 1.53, CI 1.08–2.17, 0.016), frailty/prefrailty 1.68, 1.17–2.41, 0.005), depression 2.12, 1.32–3.41, 0.002) increased use. A better nutritional status 0.88, 0.81–0.97, 0.008). sex-stratified analysis, men 0.90, 0.82–0.99, 0.032). Frailty/prefrailty 2.04, 1.18–3.54, 0.011) 0.83, 0.72–0.96, 0.011). past 12 months an prevalence women 1.74, 1.10–2.75, 0.019). Depression both 2.74, 1.20–6.24, 0.016) 2.06, 1.14–3.71, We did not detect differences regarding drugs anticholinergic effects, but more than used PIMs referring cardiovascular system (<i>p</i> 0.036), while genitourinary hormones &#x3c; 0.001). <b><i>Conclusion:</i></b> found similarities, also between as participants’ assessments. association may suggest that physicians’ behavior modified by patient education, relationship could evolve from critical attitudes educated patients towards medication conclude capacities might partly attributable classes used, regard anticholinergics, these are similar extent cohort studied here.

Язык: Английский

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Prevalencia de prescripción de fármacos con carga anticolinérgica/sedante en adultos mayores institucionalizados con demencia

Revista Española de Geriatría y Gerontología, Год журнала: 2020, Номер 56(1), С. 11 - 17

Опубликована: Дек. 11, 2020

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A comparison of anticholinergic burden in older patients with and without cancer

Future Oncology, Год журнала: 2021, Номер 17(36), С. 5067 - 5075

Опубликована: Окт. 27, 2021

Aim: To compare anticholinergic burden (ACB) in older patients with and without cancer evaluate the effects of ACB on geriatric syndromes. Methods: A total 291 from clinic 301 oncology were evaluated. <2 was categorized as low ≥2 high ACB. comprehensive assessment performed clinic. Results: scores significantly higher compared those (p < 0.005). Number falls Geriatric Depression Scale 15 Mini-Nutritional Assessment Barthel/Lawton activities daily living lower Conclusion: It is crucial to understand potential for rational drug use optimum management cancer.

Язык: Английский

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Is anticholinergic and sedative drug burden associated with postdischarge institutionalization in community‐dwelling older patients acutely admitted to hospital? A Norwegian registry‐based study

Pharmacoepidemiology and Drug Safety, Год журнала: 2022, Номер 32(6), С. 607 - 616

Опубликована: Дек. 31, 2022

Investigate the association between anticholinergic (AC) and sedative (SED) drug burden before hospitalization postdischarge institutionalization (PDI) in community-dwelling older patients acutely admitted to hospital.A cross-sectional study using data from Norwegian Patient Registry Prescription Database. We studied hospitalized ≥70 years during 2013 (N = 86 509). Patients geriatric wards underwent subgroup analyses (n 1715). calculated by Drug Burden Index (DBI), use of AC/SED drugs, number drugs. Piecewise linearity DBI versus PDI a knot point (DBI 2.45) was identified. Statistical included an adjusted multivariable logistic regression model.In total population, 45.4% were exposed at least one drug, compared 52.5% subgroup. drugs significantly associated with PDI. The odds ratios (ORs) 1.11 (95% CI 1.07-1.15) for < 2.45 1.08 1.04-1.13) ≥ 2.45. OR 1.07 1.05-1.09). AC component 1.23 1.13. In subgroup, ORs closer 1 drugs.The highly prevalent acute hospital admissions, number, or just gave similar associations applying DBI. Using showed higher sensitivity, indicating that reduce risk PDI, clinical approach could be

Язык: Английский

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Drug burden index of people ageing with intellectual disability and cognitive complaints attending a specialist memory service

Journal of Intellectual Disability Research, Год журнала: 2024, Номер 68(12), С. 1386 - 1395

Опубликована: Авг. 26, 2024

Medications with sedative or anticholinergic properties should be prescribed caution in those cognitive complaints. This is particularly relevant people ageing an intellectual disability (ID). Higher drug burden index (DBI) scores are associated increased frailty and falls reduced quality of life older risk adverse effects (daytime somnolence, constipation) ID. While previous studies have shown that the ID population has higher rates a propensity to antipsychotic than general population, degree not been assessed specifically

Язык: Английский

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