British Journal of Hospital Medicine,
Год журнала:
2023,
Номер
84(5), С. 1 - 8
Опубликована: Май 2, 2023
Hypertension
is
a
chronic
disease
with
high
levels
of
morbidity
and
disability.
Elevated
blood
pressure
can
lead
to
many
complications
the
main
risk
factor
for
stroke,
heart
failure
nephropathy.
Factors
associated
hypertension
inflammatory
response
differ
from
those
vascular
inflammation.
The
immune
system
plays
vital
role
in
pathophysiology
hypertension.
Inflammation
particularly
relevant
progression
cardiovascular
diseases,
which
has
led
extensive
research
on
markers
indicators.
Journal of Parkinson s Disease,
Год журнала:
2022,
Номер
12(s1), С. S93 - S104
Опубликована: Июнь 3, 2022
Ageing
is
a
major
risk
factor
for
most
neurodegenerative
diseases,
including
Parkinson's
disease
(PD).
Progressive
age-related
dysregulation
of
the
immune
system
termed
immunosenescence
and
responsible
weakened
response
to
novel
antigens,
increased
susceptibility
infections
reduced
effectiveness
vaccines
seen
in
elderly.
Immune
activation,
both
within
brain
periphery,
heavily
implicated
PD
but
role
has
not
been
fully
explored.
Studies
date
provide
some
evidence
an
attenuation
PD,
particularly
reduction
senescent
CD8
T
lymphocytes
cases
compared
similarly
aged
controls.
Here,
we
discuss
recent
abnormalities
with
focus
on
cell
senescence
explore
their
potential
pathogenesis
development.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 13269 - 13269
Опубликована: Окт. 31, 2022
The
immunosenescence-related
disproportion
in
T
lymphocytes
may
have
important
consequences
for
endothelial
dysfunction,
which
is
a
key
event
vascular
aging.
study
was
designed
to
assess
the
prognostic
values
of
inflammatory-immune
profile
better
predict
and
prevent
diseases
associated
with
old
age.
Eighty
individuals
aged
70.9
±
5.3
years
were
allocated
low-
(LGI)
or
high-grade
inflammation
(HGI)
group
based
on
CRP
(<3
≥3
mg/L)
as
conventional
risk
marker
cardiovascular
diseases.
Significant
changes
inflammatory
endothelium-specific
variables
IL-1β,
IL-6,
TNFα,
oxLDL,
H2O2,
NO,
3-nitrotyrosine,
progenitor
cells
(OR
7.61,
95%
CI
2.56−29.05,
p
<
0.0001),
confirmed
their
interplay
inflammation.
flow-cytometry
analysis
demonstrated
high
CD4+
CD8+
between
LGI
HGI
groups.
<3
mg/mL
CD4/CD8
ratio
within
reference
≥
1
≤2.5,
unlike
>2.5.
odds
ratios
distribution
5.98,
0.001−0.008,
0.001),
0.23,
0.08−0.59,
0.01),
CD8CD45RO+
naïve
0.27,
0.097−0.695,
0.01)
5.69,
2.07−17.32,
0.001)
indicated
potential
diagnostic
value
clinical
prognosis
aging-related
dysfunction.
Frontiers in Sports and Active Living,
Год журнала:
2023,
Номер
5
Опубликована: Май 11, 2023
Methods
This
study
examined
the
effects
of
exercise
training
for
8
weeks
on
blood
immune
cell
characteristics
among
20
breast
cancer
survivors
(age
56
±
6
years,
Body
Mass
Index
25.4
3.0
kg
m
2
)
within
two
years
treatment.
Participants
were
randomly
allocated
to
a
partly-supervised
or
remotely-supported
group
(
n
=
10
each).
The
partly
supervised
undertook
(laboratory-based
treadmill
walking
and
cycling)
1
unsupervised
session
per
week
(outdoor
walking)
progressing
from
35
50
min
55%
70%
V˙O
max.
received
weekly
exercise/outdoor
targets
(progressing
105
150
max)
via
telephone
calls
discussing
data
fitness
tracker.
Immune
counts
assessed
using
flow
cytometry:
CD4+
CD8+
T
cells
(Naïve,
NA;
Central
memory,
CM;
Effector
cells,
EM
EMRA;
CD27/CD45RA),
Stem
cell-like
memory
(TSCMs;
CD95/CD127),
B
(plasmablasts,
immature
naïve
CD19/CD27/CD38/CD10)
Natural
Killer
(effector
regulatory
CD56/CD16).
function
was
by
unstimulated
HLA-DR
expression
interferon
gamma
(IFN-γ)
production
with
Enzyme-linked
ImmunoSpot
assays
following
stimulation
virus
tumour-associated
antigens.
Results
Total
leukocyte
counts,
lymphocytes,
monocytes
neutrophils
did
not
change
p
>
0.425).
Most
subtypes,
including
TSCMs,
NK
subtypes
0.127).
However,
across
groups
combined,
EMRA
count
lower
after
(cells/µl:
18
33
vs.
12
22,
0.028)
these
less
activated
basis
(HLA-DR
median
fluorescence
intensity:
463
138
420
77,
0.018).
Furthermore,
showed
significant
decrease
in
CD4+/CD8+
ratio
(3.90
2.98
2.54
1.29,
0.006)
increase
16
21
10,
0.011).
IFN-γ
0.515).
Discussion
In
summary,
most
are
relatively
stable
survivors.
activation
might
reflect
an
anti-immunosenescence
effect
exercise.
British Journal of Hospital Medicine,
Год журнала:
2023,
Номер
84(5), С. 1 - 8
Опубликована: Май 2, 2023
Hypertension
is
a
chronic
disease
with
high
levels
of
morbidity
and
disability.
Elevated
blood
pressure
can
lead
to
many
complications
the
main
risk
factor
for
stroke,
heart
failure
nephropathy.
Factors
associated
hypertension
inflammatory
response
differ
from
those
vascular
inflammation.
The
immune
system
plays
vital
role
in
pathophysiology
hypertension.
Inflammation
particularly
relevant
progression
cardiovascular
diseases,
which
has
led
extensive
research
on
markers
indicators.
