Lipid Trajectories Improve Risk Models for Alzheimer’s Disease and Mild Cognitive Impairment DOI Creative Commons
Bruce A. Chase,

Roberta Frigerio,

Chad J. Yucus

и другие.

Journal of Lipid Research, Год журнала: 2024, Номер unknown, С. 100714 - 100714

Опубликована: Ноя. 1, 2024

In this retrospective, case-control study, we tested the hypothesis that blood-lipid concentrations during decade prior to cognitive symptom onset can inform risk prediction for Alzheimer's disease (AD) and stable mild impairment (MCI). Clinically well-characterized cases were diagnosed using DSM-IV criteria; MCI had been ≥5 years; controls propensity matched at (MCI: 116 cases, 435 controls; AD: 215 483 controls). Participants grouped based on (i) longitudinal trajectories (ii) quintile of variability independent mean (VIM) total cholesterol (TC), high-density lipoprotein (HDL-C), low-density cholesterol, non-HDL-C, ln(triglycerides). Risk models evaluated contributions lipid trajectory VIM groups relative APOE genotype or polygenic scores (PRS) AD levels major confounders: age, lipid-lowering medications, comorbidities, other correlates concentrations. with AD-PRS, higher MCI-risk was associated two lower HDL-C [odds ratios: 3.8(1.3-11.3; P=0.014), 3.2(1.1-9.3; P=0.038), high trajectory], lowest non-HDL-C ratio: 2.2 (1.3-3.8:P=0.004), quintiles 2-5]. Higher AD-risk 2.8(1.5-5.1; P=0.001), 3.7 (2.0-7.0; P<0.001)], TC 2.5(1.5-4.0: P<0.001)]. Inclusion lipid-trajectory improved risk-model predictive performance lipid-level PRS. These results provide important real-world perspectives how variation contribute decline.

Язык: Английский

Postoperative delirium risk in patients with hyperlipidemia: A prospective cohort study DOI

Yue Zhao,

Ke Zhong,

Yujie Zheng

и другие.

Journal of Clinical Anesthesia, Год журнала: 2024, Номер 98, С. 111573 - 111573

Опубликована: Авг. 2, 2024

Язык: Английский

Процитировано

6
Relationship between plasma lipid and cognitive function in the elderly based on individual's diet and ApoE, CD36, SCARB1 genetic polymorphisms DOI

Xiuwen Ren,

Xixiang Wang,

Yu Liu

и другие.

Gene Reports, Год журнала: 2025, Номер unknown, С. 102140 - 102140

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Dyslipidemia and cerebral atrophy among health check-up individuals: a cross-sectional study DOI Creative Commons

Xiaoying He,

Jingyi Xiao, Yan Wang

и другие.

International Journal of Cardiology Cardiovascular Risk and Prevention, Год журнала: 2025, Номер 25, С. 200394 - 200394

Опубликована: Март 8, 2025

To examine the association between dyslipidemia and cerebral atrophy in Chinese health check-up population. 67,526 participants underwent routine check-ups at management center of First Affiliated Hospital Sun Yat-Sen University (FAH-SYSU) Guangzhou for two years (2022-2023) this cross-sectional study. Cerebral was determined by expert physicians based on non-contrast scans Head Magnetic Resonance Imaging (MRI), Angiography (MRA) and/or Computed Tomography (CT). The levels Total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C) triglyceride (TG) were measured classified quartiles into four categories, respectively. multivariable logistic regression model used to obtain odds ratios (ORs) 95% confidence intervals (CIs). A total 1,661 included with ages from 18 93 years. Among participants, 121 (7.28%) had atrophy. On multivariate analysis, TC LDL-C not associated atrophy, although lower subgroup This study conducted China is first identify that examinees raising possible cognitive dysfunction. Future planned overcome existing limitation address lack statistically significant dementia.

Язык: Английский

Процитировано

0
Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis DOI Creative Commons

Li-quan Qiu,

Jian-li Song,

Licai Zhang

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Март 18, 2025

The association between hyperlipidemia and its potential role as a risk factor for postoperative delirium (POD) remains unclear. We systematically searched PubMed, Embase, Web of Science, Cochrane Library, ClinicalTrials.gov to identify studies meeting the inclusion criteria. Outcomes interest included comparisons blood lipid levels POD non-POD (NPOD) patients, risk, predictive value POD. A total nine involving 4,686 patients were in meta-analysis. Pooled analysis revealed that was significantly associated with an increased (OR = 1.47; 95% CI 1.13-1.91; P 0.004;) compared without hyperlipidemia. Patients exhibited higher cholesterol (TC) (weighted mean difference [WMD] 0.31; 0.03-0.59; 0.030), triglycerides (TG) (WMD 0.37; 0.03-0.71; 0.033), low-density lipoprotein (LDL-C) 0.09; 0.01-0.17; 0.023) NPOD patients. In contrast, high-density (HDL-C) lower -0.07; -0.12 -0.01; 0.026). Insufficient evidence available summarize area under curve (AUC) results. Blood elevated Hyperlipidemia POD, highlighting factor.

Язык: Английский

Процитировано

0
Association between platelet-to-high-density lipoprotein cholesterol ratio and cognitive function in older americans: insights from a cross-sectional study DOI Creative Commons
Tianyi Wang,

Ruwen Zheng,

Siqi Zhang

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 28, 2024

The main aim of this study was to explore the correlation between platelet/high-density lipoprotein cholesterol ratio (PHR) and cognitive function in elderly individuals from United States. This investigation leveraged data encompassing 2299 participants, all aged 60 years above, National Health Nutrition Examination Survey conducted 2011 2014. Inclusion criteria were based on availability complete datasets for PHR assessments. analytical approach incorporated multivariate logistic regression discern association function. Additionally, employed restricted cubic splines (RCS) potential non-linear relationships subgroup analyses identify variations observed associations across different demographic clinical subgroups. In fully adjusted model, an increment 10 units associated with a decline 0.014 scores (β=-0.014, 95% CI: -0.025, -0.002; P < 0.05). Compared lowest quartile, participants highest quartile exhibited 38.4% increased prevalence impairment per one-unit increase (OR = 1.384, 1.012, 1.893; Subgroup analysis revealed consistent results regarding relationship A using RCS, indicating that above 111.49 significantly elevated incidence (P Our demonstrates higher is greater risk older U.S. population, although further validation needed, warrants consideration assessments interventions.

Язык: Английский

Процитировано

1
Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and Cognitive Function in Older Americans: Insights from a Cross-Sectional Study DOI Creative Commons

Ruwen Zheng,

Siqi Zhang,

Hongyu Qin

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

Abstract Aims The main aim of this study was to explore the correlation between platelet/high-density lipoprotein cholesterol ratio (PHR) and cognitive function in elderly individuals from United States. Methods This investigation leveraged data encompassing 2299 participants, all aged 60 years above, National Health Nutrition Examination Survey conducted 2011 2014. Inclusion criteria were based on availability complete datasets for PHR assessments. analytical approach incorporated multivariate logistic regression discern association impairment. Additionally, employed restricted cubic splines (RCS) potential non-linear relationships subgroup analyses identify variations observed associations across different demographic clinical subgroups. Results In fully adjusted model, an increment 10 units associated with a decline 0.014 scores (β=-0.014, 95% CI: -0.025, -0.002; P<0.05). Compared lowest quartile, participants highest quartile exhibited 38.4% increased prevalence impairment per one-unit increase (OR=1.384, 1.012, 1.893; P<0.05). Subgroup analysis revealed consistent results regarding relationship A using RCS, indicating that above 111.49 significantly elevated incidence (P<0.05). Conclusions Our proves higher is linked greater risk U.S. population, warranting consideration assessments interventions.

Язык: Английский

Процитировано

0
Lipid trajectories improve risk models for Alzheimer's disease and mild cognitive impairment DOI Creative Commons
Bruce A. Chase,

Roberta Frigerio,

Chad J. Yucus

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Abstract To assess the relationship between lipids and cognitive dysfunction, we retrospectively analyzed blood-lipid levels in clinically well-characterized individuals with stable mild impairment (MCI) or Alzheimer’s disease (AD) over decade prior to first symptoms. In this case/control cohort study, AD MCI cases were diagnosed using DSM-IV criteria; had not progressed dementia for ≥5 years; controls propensity matched at age of symptom onset (MCI: 116 cases, 435 controls; AD: 215 483 controls). Participants grouped based on longitudinal trajectories quintile variability independent mean (VIM) total cholesterol, HDL-C, LDL-C, non-HDL-C ln(triglycerides). Models risk dysfunction evaluated trajectory VIM groups, APOE genotype, polygenic scores (PRS) lipid levels, age, comorbidities, correlates concentrations. Lower HDL-C (OR = 3.8, 95% CI 1.3–11.3) lowest 2.2, 1.3–3.0) associated higher risk. 3.0, 1.6–5.7) cholesterol 2.4, 1.5–3.9) The inclusion lipid-trajectory groups improved risk-model predictive performance genotype PRS levels. These results provide an important real-world perspective influence metabolism development AD.

Язык: Английский

Процитировано

0
Lipid Trajectories Improve Risk Models for Alzheimer’s Disease and Mild Cognitive Impairment DOI Creative Commons
Bruce A. Chase,

Roberta Frigerio,

Chad J. Yucus

и другие.

Journal of Lipid Research, Год журнала: 2024, Номер unknown, С. 100714 - 100714

Опубликована: Ноя. 1, 2024

In this retrospective, case-control study, we tested the hypothesis that blood-lipid concentrations during decade prior to cognitive symptom onset can inform risk prediction for Alzheimer's disease (AD) and stable mild impairment (MCI). Clinically well-characterized cases were diagnosed using DSM-IV criteria; MCI had been ≥5 years; controls propensity matched at (MCI: 116 cases, 435 controls; AD: 215 483 controls). Participants grouped based on (i) longitudinal trajectories (ii) quintile of variability independent mean (VIM) total cholesterol (TC), high-density lipoprotein (HDL-C), low-density cholesterol, non-HDL-C, ln(triglycerides). Risk models evaluated contributions lipid trajectory VIM groups relative APOE genotype or polygenic scores (PRS) AD levels major confounders: age, lipid-lowering medications, comorbidities, other correlates concentrations. with AD-PRS, higher MCI-risk was associated two lower HDL-C [odds ratios: 3.8(1.3-11.3; P=0.014), 3.2(1.1-9.3; P=0.038), high trajectory], lowest non-HDL-C ratio: 2.2 (1.3-3.8:P=0.004), quintiles 2-5]. Higher AD-risk 2.8(1.5-5.1; P=0.001), 3.7 (2.0-7.0; P<0.001)], TC 2.5(1.5-4.0: P<0.001)]. Inclusion lipid-trajectory improved risk-model predictive performance lipid-level PRS. These results provide important real-world perspectives how variation contribute decline.

Язык: Английский

Процитировано

0