Metabolites,
Год журнала:
2022,
Номер
12(11), С. 1026 - 1026
Опубликована: Окт. 26, 2022
Exercise
intolerance
is
a
major
manifestation
of
post-acute
sequelae
severe
acute
respiratory
syndrome
coronavirus
infection
(PASC,
or
"long-COVID").
in
PASC
associated
with
higher
arterial
blood
lactate
accumulation
and
lower
fatty
acid
oxidation
rates
during
graded
exercise
tests
to
volitional
exertion,
suggesting
altered
metabolism
mitochondrial
dysfunction.
It
remains
unclear
whether
the
profound
disturbances
that
have
been
identified
plasma
from
patients
suffering
disease
2019
(COVID-19)
are
also
present
PASC.
To
bridge
this
gap,
individuals
history
previous
COVID-19
did
not
require
hospitalization
were
enrolled
at
National
Jewish
Health
(Denver,
CO,
USA)
grouped
into
those
developed
(n
=
29)
fully
recovered
16).
Plasma
samples
two
groups
analyzed
via
mass
spectrometry-based
untargeted
metabolomics
compared
against
metabolic
profiles
healthy
control
30).
Observational
demographic
clinical
data
retrospectively
abstracted
medical
record.
Compared
controls
who
COVID-19,
exhibited
significantly
free-
carnitine-conjugated
mono-,
poly-,
highly
unsaturated
acids,
accompanied
by
markedly
levels
di-
tricarboxylates
(pyruvate,
lactate,
citrate,
succinate,
malate),
polyamines
(spermine)
taurine.
an
intermediary
phenotype,
milder
spermine
Of
note,
depletion
tryptophan-a
hallmark
severity
COVID-19-is
normalized
patients,
despite
normalization
kynurenine
levels-a
tryptophan
metabolite
predicts
mortality
hospitalized
patients.
In
conclusion,
metabolites
indicative
dysfunctional
mitochondria-dependent
lipid
catabolism.
These
obtained
rest
consistent
previously
reported
dysfunction
exercise,
may
pave
way
for
therapeutic
intervention
focused
on
restoring
fat-burning
capacity.
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(16), С. 10362 - 10362
Опубликована: Авг. 19, 2022
The
physio-affective
phenome
of
Long
COVID-19
is
predicted
by
(a)
immune-inflammatory
biomarkers
the
acute
infectious
phase,
including
peak
body
temperature
(PBT)
and
oxygen
saturation
(SpO2),
(b)
subsequent
activation
immune
oxidative
stress
pathways
during
COVID.
purpose
this
study
was
to
delineate
effects
PBT
SpO2
infection,
as
well
increased
neurotoxicity
on
physical,
psychological,
social
environmental
domains
health-related
quality
life
(HR-QoL)
in
people
with
We
recruited
86
participants
COVID
39
normal
controls,
assessed
WHO-QoL-BREF
(World
Health
Organization
Quality
Life
Instrument-Abridged
Version,
Geneva,
Switzerland)
(comprising
depression,
anxiety
fibromyalgia-fatigue
rating
scales)
measured
(NT,
comprising
serum
interleukin
(IL)-1β,
IL-18
caspase-1,
advanced
oxidation
protein
products
myeloperoxidase,
calcium
insulin
resistance)
found
that
70.3%
variance
HR-QoL
explained
regression
phenome,
lowered
NT,
whilst
61.5%
calcium,
PBT,
SpO2,
female
sex
vaccination
AstraZeneca
Pfizer.
were
mediated
NT
yielding
severity
which
largely
affects
HR-QoL.
In
conclusion,
HR-Qol
neuro-immune
neuro-oxidative
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 23, 2022
In
patients
with
SARS-CoV-2,
innate
immunity
is
playing
a
central
role,
depicted
by
hyperinflammation
and
longer
lasting
inflammatory
response.
Reliable
markers
that
cover
both
acute
long-lasting
COVID-19
monitoring
are
still
lacking.
Thus,
we
investigated
one
specific
marker
involved
as
key
player
of
the
immune
system,
kynurenine
(Kyn),
its
use
for
diagnosis/detection
Long-/Post-COVID
syndrome
in
comparison
to
currently
used
serum
saliva
samples.
Frontiers in Molecular Neuroscience,
Год журнала:
2023,
Номер
16
Опубликована: Июнь 2, 2023
Critical
COVID-19
disease
is
accompanied
by
depletion
of
plasma
tryptophan
(TRY)
and
increases
in
indoleamine-dioxygenase
(IDO)-stimulated
production
neuroactive
catabolites
(TRYCATs),
including
kynurenine
(KYN).
The
TRYCAT
pathway
has
not
been
studied
extensively
association
with
the
physiosomatic
affective
symptoms
Long
COVID.
In
present
study,
we
measured
serum
TRY,
TRYCATs,
insulin
resistance
(using
Homeostatic
Model
Assessment
Index
2-insulin
resistance,
HOMA2-IR),
C-reactive
protein
(CRP),
physiosomatic,
depression,
anxiety
90
COVID
patients,
3-10
months
after
remission
acute
infection.
We
were
able
to
construct
an
endophenotypic
class
severe
(22%
patients)
very
low
TRY
oxygen
saturation
(SpO2,
during
infection),
increased
kynurenine,
KYN/TRY
ratio,
CRP,
high
ratings
on
all
symptom
domains.
One
factor
could
be
extracted
from
(including
chronic
fatigue-fibromyalgia),
symptoms,
indicating
that
domains
are
manifestations
common
physio-affective
phenome.
Three
biomarkers
(CRP,
KYN/TRY,
IR)
explained
around
40%
variance
latter
ratio
significantly
predicted
peak
body
temperature
(PBT)
lowered
SpO2
validated
latent
vector
three
a
composite
based
IR
(Long
COVID),
PBT
(acute
COVID-19).
conclusion,
phenome
manifestation
inflammatory
responses
COVID,
may
contribute
these
effects.
Brain Behavior & Immunity - Health,
Год журнала:
2022,
Номер
26, С. 100537 - 100537
Опубликована: Окт. 21, 2022
There
is
now
evidence
that
affective
disorders
including
major
depressive
disorder
(MDD)
and
bipolar
(BD)
are
mediated
by
immune-inflammatory
nitro-oxidative
pathways.
Activation
of
these
pathways
may
be
associated
with
activation
the
tryptophan
catabolite
(TRYCAT)
pathway
inducing
indoleamine
2,3-dioxygenase
(IDO,
rate-limiting
enzyme)
leading
to
depletion
(TRP)
increases
in
catabolites
(TRYCATs).
To
systematically
review
meta-analyze
central
peripheral
(free
total)
TRP
levels,
its
competing
amino-acids
(CAAs)
TRYCATs
MDD
BD.
This
searched
PubMed,
Google
Scholar
SciFinder
included
121
full-text
articles
15470
individuals,
8024
MDD/BD
patients
7446
healthy
controls.
levels
(either
free
TRP/CAAs
ratio
were
significantly
decreased
(p
<
0.0001)
as
compared
controls
a
moderate
effect
size
(standardized
mean
difference
for
TRP:
SMD
=
−0.513,
95%
confidence
interval,
CI:
−0.611;
−0.414;
TRP/CAAs:
−0.558,
−0.758;
−0.358).
Kynurenine
(KYN)
small
0.0001,
−0.213,
95%CI:
−0.295;
−0.131).
These
differences
significant
plasma
−0.304,
−0.415,
−0.194)
but
not
serum
0.054)
or
nervous
system
(CNS,
p
0.771).
The
KYN/TRP
ratio,
frequently
used
an
index
IDO
activity,
neurotoxicity
indices
based
on
downstream
unaltered
even
lowered
MDD/BD.
Our
findings
suggest
BD
accompanied
without
TRYCAT
activation.
Lowered
availability
probably
consequence
albumin
during
inflammatory
response
disorders.
Acta Neuropsychiatrica,
Год журнала:
2022,
Номер
35(2), С. 76 - 87
Опубликована: Сен. 22, 2022
Long
coronavirus
disease
2019
(LC)
is
a
chronic
sequel
of
acute
COVID-19.
The
exact
pathophysiology
the
affective,
fatigue
and
physiosomatic
symptoms
(labelled
as
"physio-affective
phenome")
LC
has
remained
elusive.The
current
study
aims
to
delineate
effects
oxygen
saturation
(SpO2)
body
temperature
during
phase
on
physio-affective
phenome
LC.We
recruited
120
patients
36
controls.
For
all
participants,
we
assessed
lowest
SpO2
peak
COVID-19,
Hamilton
Depression
Anxiety
Rating
Scale
(HAMD/HAMA)
Fibro
Fatigue
(FF)
scales
3-4
months
later.Lowered
increased
female
sex
predict
60.7%
variance
in
LC.
Using
unsupervised
learning
techniques,
were
able
new
endophenotype
class,
which
comprises
around
26.7%
characterised
by
very
low
high
temperature,
depression,
anxiety,
fatigue,
autonomic
gastro-intestinal
scores.
Single
latent
vectors
could
be
extracted
from
both
biomarkers,
anxiety
FF
or
insomnia,
symptoms.The
newly
constructed
class
pathway
phenotypes
indicate
that
at
least
part
consequence
namely
combined
lowered
SpO2,
associated
immune-inflammatory
processes
lung
lesions.
Microorganisms,
Год журнала:
2023,
Номер
11(2), С. 452 - 452
Опубликована: Фев. 10, 2023
Gut
microbiota
is
increasingly
recognized
to
play
a
pivotal
role
in
various
human
physiological
functions
and
diseases.
Amidst
the
COVID-19
pandemic,
research
has
suggested
that
dysbiosis
of
gut
also
involved
development
severity
symptoms
by
regulating
SARS-CoV-2
entry
modulating
inflammation.
Previous
studies
have
their
metabolites
could
immunomodulatory
effects
on
vaccine
immunogenicity,
including
influenza
vaccines
oral
rotavirus
vaccines.
In
light
these
observations,
it
possible
plays
influencing
immune
responses
vaccinations
via
similar
mechanisms
lipopolysaccharides,
flagellin,
peptidoglycan,
short-chain
fatty
acids.
this
review,
we
give
an
overview
current
understanding
manifestations
immunogenicity.
We
then
discuss
limitations
currently
published
associations
between
outcomes.
Future
directions
shall
be
focused
microbiota-based
interventions
improving
response
infection
vaccinations.
Bioscience Reports,
Год журнала:
2023,
Номер
43(8)
Опубликована: Июль 24, 2023
Abstract
SARS-CoV-2
(COVID-19)
exerts
profound
changes
in
the
kynurenine
(Kyn)
pathway
(KP)
of
tryptophan
(Trp)
metabolism
that
may
underpin
its
pathophysiology.
The
KP
is
main
source
vital
cellular
effector
NAD+
and
intermediate
metabolites
modulate
immune
neuronal
functions.
Trp
top
influenced
by
COVID-19.
Sixteen
studies
established
virus-induced
activation
mediated
mainly
induction
indoleamine
2,3-dioxygenase
(IDO1)
most
affected
tissues
IDO2
lung
increased
release
proinflammatory
cytokines
but
could
additionally
involve
flux
plasma
free
(TDO)
cortisol.
major
Kyn
metabolite
targeted
COVID-19
kynurenic
acid
(KA),
with
greatest
affinity
for
aryl
hydrocarbon
receptor
(AhR),
which
also
activated
AhR
initiates
two
important
series
events:
a
vicious
circle
involving
IDO1
induction,
KA
accumulation
further
activation,
poly
(ADP-ribose)
polymerase
(PARP)
leading
to
depletion
cell
death.
virus
deprives
host
inhibiting
biosynthetic
from
quinolinic
acid,
while
simultaneously
acquiring
promoting
synthesis
nicotinamide
salvage
pathway.
Additionally,
protective
effects
sirtuin
1
are
minimised
PARP
activation.
dysfunction
mood
neurological
disorders
acutely
during
‘long
COVID’.
More
potential
vaccination
therapy
on
required
exploration
therapeutic
strategies
modulation
proposed.
Diagnostics,
Год журнала:
2024,
Номер
14(3), С. 244 - 244
Опубликована: Янв. 24, 2024
(1)
Background:
COVID-19
was
responsible
for
the
latest
pandemic,
shaking
and
reshaping
healthcare
systems
worldwide.
Its
late
clinical
manifestations
make
it
linger
in
medical
memory
as
a
debilitating
illness
over
extended
periods.
(2)
Methods:
recent
literature
systematically
analyzed
to
categorize
examine
symptomatology
pathophysiology
of
Long
COVID
across
various
bodily
systems,
including
pulmonary,
cardiovascular,
gastrointestinal,
neuropsychiatric,
dermatological,
renal,
hematological,
endocrinological
aspects.
(3)
Results:
The
review
outlines
diverse
multiple
emphasizing
its
complexity
challenges
diagnosis
treatment.
Factors
such
pre-existing
conditions,
initial
severity,
vaccination
status,
gender,
age
were
identified
influential
manifestation
persistence
symptoms.
This
condition
is
highlighted
disease
capable
enduring
an
period
presenting
new
symptoms
time.
(4)
Conclusions:
emerges
with
intricate
multi-systemic
involvement,
complicating
findings
underscore
necessity
nuanced
understanding
effectively
manage
address
evolving
nature
this
