Amino
acid
metabolism
provides
significant
insight
into
the
development
and
prevention
of
many
viral
diseases.
Therefore,
present
study
aimed
to
compare
amino
profiles
hand,
foot,
mouth
disease
(HFMD)
patients
with
those
healthy
individuals
further
reveal
molecular
mechanisms
HFMD
severity.
Using
UPLC-MS/MS,
we
determined
plasma
expression
pediatric
(mild,
n
=
42;
severe,
43)
controls
(n
25).
Brain
tissues
from
CVA6-infected
mice
were
examined
using
untargeted
metabolomics.
Several
acids
significantly
different
between
three
groups.
Pathway
analysis
revealed
that
arginine,
proline,
tryptophan
are
implicated
in
pathogenesis
HFMD.
A
similar
arginine
depletion
was
observed
brain
mice.
Importantly,
L-arginine
supplementation
improved
survival
rate
mice,
inhibited
virus
multiplication,
reduced
pathological
autophagy
associated
mTOR-autophagy
pathway
brain.
Collectively,
as
hub
metabolite
mammalian
target
rapamycin
(mTOR)
signaling
affecting
autophagy,
plays
an
important
role
severe
may
serve
a
potential
therapeutic
option
for
critical
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9082 - 9082
Опубликована: Авг. 21, 2024
Kynurenic
acid
(KYNA)
is
an
antioxidant
degradation
product
of
tryptophan
that
has
been
shown
to
have
a
variety
cytoprotective,
neuroprotective
and
neuronal
signalling
properties.
However,
mammalian
transporters
receptors
display
micromolar
binding
constants;
these
are
consistent
with
its
typically
tissue
concentrations
but
far
above
serum/plasma
concentration
(normally
tens
nanomolar),
suggesting
large
gaps
in
our
knowledge
transport
mechanisms
action,
the
main
influx
characterized
date
equilibrative,
not
concentrative.
In
addition,
it
substrate
known
anion
efflux
pump
(ABCC4),
whose
vivo
activity
largely
unknown.
Exogeneous
addition
L-tryptophan
or
L-kynurenine
leads
production
KYNA
also
many
other
co-metabolites
(including
some
such
as
3-hydroxy-L-kynurenine
quinolinic
may
be
toxic).
With
exception
chestnut
honey,
exists
at
relatively
low
levels
natural
foodstuffs.
bioavailability
reasonable,
terminal
element
irreversible
reaction
most
pathways,
might
added
exogenously
without
disturbing
upstream
metabolism
significantly.
Many
examples,
which
we
review,
show
valuable
bioactivity.
Given
above,
review
potential
utility
nutraceutical,
finding
significantly
worthy
further
study
development.
Nutrients,
Год журнала:
2024,
Номер
16(19), С. 3380 - 3380
Опубликована: Окт. 4, 2024
Background:
Tryptophan
is
widely
present
in
foods
such
as
peanuts,
milk,
and
bananas,
playing
a
crucial
role
maintaining
metabolic
homeostasis
health
disease.
metabolism
involved
the
development
progression
of
immune,
nervous,
digestive
system
diseases.
Although
some
excellent
reviews
on
tryptophan
exist,
there
has
been
no
systematic
scientometric
study
yet.
Methods:
This
review
provides
summarizes
research
hotspots
potential
future
directions
by
analyzing
annual
publications,
topics,
keywords,
highly
cited
papers
sourced
from
Web
Science
spanning
1964
to
2022.
Results:
overview
disorder-triggered
diseases,
mechanisms,
therapeutic
strategies.
Conclusions:
The
gut
microbiota
regulates
permeability,
inflammation,
host
immunity
directly
converting
indole
its
derivatives.
Gut
microbial
metabolites
regulate
activating
specific
receptors
or
enzymes.
Additionally,
kynurenine
(KYN)
pathway,
activated
indoleamine-2,
3-dioxygenase
(IDO)
2,
3-dioxygenase,
affects
migration
invasion
glioma
cells
COVID-19
depression.
IDO
inhibitors
help
improve
effectiveness
immunotherapy.
markers
are
used
for
disease
therapy,
guiding
clinical
decision-making.
serve
targets
provide
new
promising
strategy
neuroprotective/neurotoxic
imbalance
affecting
brain
structure
function.
In
summary,
this
valuable
guidance
basic
application
metabolism.
Pharmacological Research,
Год журнала:
2025,
Номер
213, С. 107670 - 107670
Опубликована: Фев. 20, 2025
Sirtuin
1
(SIRT1),
a
NAD+
-dependent
histone
deacetylase,
plays
crucial
role
in
mitigating
oxidative
stress,
regulating
inflammation,
and
maintaining
mitochondrial
function.
Reduced
SIRT1
activity
has
been
linked
to
elevated
pro-inflammatory
cytokines,
dysfunction,
chronic
pain,
all
of
which
are
observed
long
COVID
pathology.
Emerging
evidence
identifies
dysfunction
stress
as
central
contributors
these
symptoms.
Increases
reactive
oxygen
species
(ROS)
such
superoxide,
nitric
oxide,
peroxynitrite,
leading
damage,
central/peripheral
sensitization.
Nutraceuticals,
particularly
the
polyphenolic
fraction
bergamot
(BPF),
have
demonstrated
potent
antioxidant,
anti-inflammatory,
antiviral
properties.
This
study
highlights
BPF's
ability
modulate
rat
model
inflammation
hyperalgesia.
It
provides
novel
nitration
within
nucleus
key
event
inflammatory
pain
pathogenesis.
BPF
administration
preserved
activity,
reduced
markers
malondialdehyde
(MDA)
8-hydroxydeoxyguanosine
(8-OHdG),
minimized
post-translational
modifications
nuclear
proteins,
including
nitration,
acetylation,
carbonylation.
Additionally,
it
alleviated
hyperalgesia
allodynia.
These
findings
underscore
therapeutic
potential
polyphenols
like
reducing
inflammation-driven
pain.
By
activating
SIRT1,
may
provide
relief
for
conditions.
Further
research
on
SIRT1-targeted
therapies
is
essential
combat
preventing
conditions
enhancing
treatment
options.
Bioscience Reports,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 22, 2024
Coronaviruses
constitute
a
significant
threat
to
the
human
population.
Severe
acute
respiratory
syndrome
coronavirus-2,
SARS-CoV-2,
is
highly
pathogenic
coronavirus
that
has
caused
COVID-19
pandemic.
It
led
global
viral
outbreak
with
an
exceptional
spread
and
high
death
toll,
highlighting
need
for
effective
antiviral
strategies.
3-chymotrypsin-like
protease
(3CLpro),
main
in
plays
indispensable
role
SARS-CoV-2
life
cycle
by
cleaving
polyprotein
produce
eleven
individual
non-structural
proteins
necessary
replication.
3CLpro
one
of
two
proteases
function
new
particles.
conserved
cysteine
identical
structural
folds
all
known
coronaviruses.
Inhibitors
binding
affinity
will
prevent
cleavage
polyproteins,
thus
impeding
Multiple
strategies
have
been
implemented
screen
inhibitors
against
3CLpro,
including
peptide-like
small
molecule
covalently
non-covalently
bind
active
site,
respectively.
In
addition,
allosteric
sites
identified
molecules
could
make
non-competitive
3CLpro.
essence,
this
review
serves
as
comprehensive
guide
understanding
intricacies
functional
dynamics
emphasizing
key
findings
elucidate
its
SARS-CoV-2.
Notably,
critical
resource
recognizing
advancements
identifying
developing
COVID-19,
some
which
are
already
approved
clinical
use
patients.
Talanta,
Год журнала:
2023,
Номер
268, С. 125295 - 125295
Опубликована: Окт. 9, 2023
The
COVID-19
pandemic
challenged
the
management
of
technical
and
human
resources
in
intensive
care
units
(ICU)
across
world.
Several
long-term
predictors
for
disease
progression
have
been
discovered.
However,
to
support
short-term
planning
medication
that
can
be
translated
future
pandemics
are
still
missing.
A
workflow
was
established
identify
a
predictor
acute
phase
patients
clinical
decision-making.
Thirty-two
with
SARS-CoV-2
infection
were
recruited
on
admission
ICU
data
collected.
During
their
hospitalization,
plasma
samples
acquired
from
each
patient
multiple
occasions,
excepting
one
which
only
time
point
possible,
proteome
(Inflammation,
Immune
Response
Organ
Damage
panels
Olink®
Target
96),
metabolome
lipidome
(flow
injection
analysis
liquid
chromatography-mass
spectrometry)
analyzed
sample.
Patient
visits
grouped
according
changes
severity
based
respiratory
organ
function,
evaluated
using
combination
statistical
machine
learning.
resulting
this
multi-omics
approach
compared
assessment
progression.
Furthermore,
potential
markers
baseline
levels
50
healthy
subjects
no
known
or
other
viral
infections.
total
124
parameters,
271
proteins
782
unique
metabolites
lipids
assessed.
dimensionality
dataset
reduced,
selecting
47
1177
parameters
available
following
down-selection,
build
learning
model.
Subsequently,
two
(C–C
motif
chemokine
7
(CCL7)
carbonic
anhydrase
14
(CA14))
lipid
(hexosylceramide
18:2;
O2/20:0)
linked
studied
Thus,
delivering
prognosis
an
upcoming
worsening
patient's
condition
up
five
days
advance
reasonable
accuracy
(79
%
three
prior
event,
84
four
event)
found.
Interestingly,
predictor's
performance
complementary
clinicians'
capabilities
foresee
patient.
This
study
presents
omics-based
biomarkers
decision-making
resource
ICU.
successfully
applied
develop
aggravation
symptoms.
methods
adapted
small
cohort
studies.
