Introduction:
The
emergency
of
the
SARS-CoV-2
virus
spread
and
its
subsequent
global
pan-demic
have
raised
significant
concerns
regarding
impact
on
pregnancy
outcomes.
This
review
aims
to
summarize
emerging
data
risk
preterm
delivery
in
pregnant
women
infected
with
SARS-CoV-2.
Materials
Methods:
A
systematic
search
was
conducted
from
March
2020
December
2023
using
PubMed,
following
PRISMA
guidelines.
Studies
correlating
maternal
COVID-19
infection
birth
were
included.
Results:
Thirteen
studies
analyzed,
indicating
a
higher
incidence
positive
compared
controls.
average
rate
pre-term
patients
18.5%,
median
12.75%,
while
non
showed
an
10%
8.2%.
Discussion:
suggest
association
between
during
increased
cesarean
section.
Severity
symptoms
underlying
comorbidities
further
elevate
this
risk.
Notably,
infections
third
trimester
pose
highest
birth.
Conclusion:
Preventing
is
crucial
mitigate
adverse
obstetric
Close
monitoring
tailored
interventions
for
women,
particularly
those
later
trimesters
comorbidities,
are
imperative
reduce
improve
maternal-fetal
JAMA Network Open,
Год журнала:
2023,
Номер
6(3), С. e234415 - e234415
Опубликована: Март 23, 2023
Importance
Prior
studies
using
large
registries
have
suggested
a
modest
increase
in
risk
for
neurodevelopmental
diagnoses
among
children
of
mothers
with
immune
activation
during
pregnancy,
and
such
may
be
sex-specific.
Objective
To
determine
whether
utero
exposure
to
SARS-CoV-2
is
associated
sex-specific
disorders
up
18
months
after
birth,
compared
unexposed
offspring
born
or
prior
the
COVID-19
pandemic
period.
Design,
Setting,
Participants
This
retrospective
cohort
study
included
live
all
who
delivered
between
January
1
December
31,
2018
(born
followed
before
pandemic),
March
2019
1,
2020,
May
2021
pandemic).
Offspring
were
at
any
8
hospitals
across
2
health
systems
Massachusetts.
Exposures
Polymerase
chain
reaction
evidence
maternal
infection
pregnancy.
Main
Outcomes
Measures
Electronic
record
documentation
International
Statistical
Classification
Diseases
Related
Health
Problems,
Tenth
Revision
diagnostic
codes
corresponding
disorders.
Results
The
355
births
(9399
boys
[51.2%]),
including
883
(4.8%)
positivity
1809
Asian
individuals
(9.9%),
1635
Black
(8.9%),
12
718
White
(69.3%),
1714
(9.3%)
other
race
(American
Indian
Alaska
Native,
Native
Hawaiian
Pacific
Islander,
more
than
race);
2617
(14.3%)
Hispanic
ethnicity.
Mean
age
was
33.0
(IQR,
30.0-36.0)
years.
In
adjusted
regression
models
accounting
race,
ethnicity,
insurance
status,
hospital
type
(academic
center
vs
community),
age,
preterm
statistically
significant
elevation
male
(adjusted
OR,
1.94
[95%
CI
1.12-3.17];
P
=
.01)
but
not
female
0.89
CI,
0.39-1.76];
.77).
Similar
effects
identified
matched
analyses
lieu
regression.
At
months,
observed
1.42
0.92-2.11];
.10).
Conclusions
Relevance
this
utero,
greater
magnitude
following
birth.
As
infection,
substantially
larger
cohorts
longer
follow-up
will
required
reliably
estimate
refute
risk.
Medicina,
Год журнала:
2023,
Номер
59(2), С. 279 - 279
Опубликована: Янв. 31, 2023
Magnesium
is
the
fourth
most
common
mineral
in
human
body
and
second
richest
intracellular
cation.
This
element
necessary
for
many
physiological
reactions,
especially
cardiovascular
respiratory
systems.
COVID-19
an
infectious
disease
caused
by
SARS-CoV-2.
The
majority
of
people
who
become
ill
as
a
result
have
mild-to-moderate
symptoms
recover
without
specific
treatment.
Moreover,
there
are
develop
severe
forms
COVID-19,
which
require
highly
specialized
medical
assistance.
deficiency
may
play
role
pathophysiology
infection
with
primary
manifestation
remains
respiratory,
but
virus
can
spread
to
other
organs
tissues,
complicating
clinical
picture
culminating
multiorgan
failure.
key
mechanisms
involved
include
direct
viral
cytotoxicity,
endothelial
dysfunction,
exaggerated
release
inflammatory
cytokines.
aim
this
review
was
summarize
available
data
regarding
magnesium
patients
its
particularities
different
settings.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 24, 2024
Abstract
It
is
unclear
if
SARS
CoV-2
infection
during
pregnancy
associated
with
adverse
neurodevelopmental
repercussions
to
infants.
We
assessed
pediatric
outcomes
in
children
born
mothers
laboratory-confirmed
pregnancy.
Neurodevelopmental
of
in-utero
exposed
were
compared
that
pre-pandemic
control
Los
Angeles
(LA),
CA,
USA
and
Rio
de
Janeiro,
Brazil.
Bayley
Scales
Infant
Toddler
Development,
3rd
edition
(Bayley-III),
the
gold
standard
tool
for
evaluating
neurodevelopment
until
36
months
age
Ages
Stages
Questionnaires
(ASQ-3),
a
frequently
used
screening
instrument
this
same
group
assessment
tools
used.
Developmental
delay
(DD)
was
defined
as
having
score
<
−
2
SD
below
norm
(<
70)
at
least
one
three
Bayley-III
domains,
(cognitive,
motor
or
language)
cut-off
(dark
zone)
five
ASQ-3
domains
(communication,
gross
motor,
fine
problem
solving,
personal-social).
Exposed
between
April
2020
December
2022
while
January
2016
2019.
testing
performed
300
total:
172
COVID-19
5–30
128
6–38
age.
results
demonstrated
12
(9.4%)
had
DD
versus
controls
(1.6%),
p
=
0.0007.
Eight
44
additional
on
testing.
Fully,
20
(11.6%)
0.0006
DD.
In
Rio,
12%
2.6%
controls,
0.02
LA,
5.7%
0
0.12
Severe/critical
maternal
predicted
average
cohort
(OR
2.6,
95%
CI
1.1–6.4).
Children
antenatal
have
tenfold
higher
frequency
should
be
offered
follow-up.
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 282 - 282
Опубликована: Янв. 24, 2025
Introduction:
The
emergence
of
the
SARS-CoV-2
virus
and
its
subsequent
global
pandemic
have
raised
significant
concerns
regarding
impact
on
pregnancy
outcomes.
This
review
aims
to
summarize
emerging
data
risk
preterm
delivery
in
pregnant
women
infected
with
SARS-CoV-2.
Materials
Methods:
A
systematic
search
was
conducted
from
March
2020
December
2023
using
PubMed
Web
Science,
following
PRISMA
guidelines.
Studies
correlating
maternal
COVID-19
infection
birth
were
included.
Results:
Thirteen
studies
analyzed,
indicating
a
higher
incidence
SARS-CoV-2-positive
compared
controls.
average
rate
patients
18.5%,
median
12.75%,
while
non-infected
showed
an
10%,
8.2%.
Discussion:
suggest
association
between
during
increased
cesarean
section.
severity
symptoms
underlying
comorbidities
further
elevate
this
risk.
Notably,
infections
third
trimester
pose
highest
birth.
Conclusion:
Preventing
is
crucial
mitigate
adverse
obstetric
Close
monitoring
tailored
interventions
for
women,
particularly
those
later
trimesters
comorbidities,
are
imperative
reduce
improve
maternal-fetal
Epidemiology,
Год журнала:
2023,
Номер
34(3), С. 430 - 438
Опубликована: Фев. 20, 2023
Background:
Randomized
trials
in
pregnancy
are
extremely
challenging,
and
observational
studies
often
the
only
option
to
evaluate
medication
safety
during
pregnancy.
However,
such
susceptible
immortal
time
bias
if
treatment
initiation
occurs
after
zero
of
follow-up.
We
describe
how
emulating
a
sequence
target
avoids
apply
approach
estimate
antibiotic
between
24
37
weeks
gestation
on
preterm
delivery.
Methods:
The
Tsepamo
Study
captured
birth
outcomes
at
hospitals
throughout
Botswana
from
2014
2021.
emulated
13
sequential
versus
no
among
individuals
presenting
care
<24
weeks,
one
for
each
week
weeks.
For
trial,
eligible
had
not
previously
initiated
antibiotics.
also
conducted
an
analysis
by
defining
as
exposure
calculated
adjusted
risk
ratios
(RR)
95%
confidence
intervals
(CI)
Results:
Of
111,403
individuals,
17,009
(15.3%)
antibiotics
In
trials,
RRs
(95%
CIs)
ranged
1.04
(0.90,
1.19)
1.24
(1.11,
1.39)
(pooled
RR:
1.11
[1.06,
1.15]).
bias,
RR
was
0.90
(0.86,
0.94).
Conclusions:
Defining
any
follow-up
resulted
substantial
making
appear
protective
against
Conducting
can
avoid
studies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(5), С. 4550 - 4550
Опубликована: Фев. 25, 2023
The
outbreak
of
the
coronavirus
disease
2019
(COVID-19)
pandemic,
caused
by
novel
severe
acute
respiratory
syndrome
2
(SARS-CoV-2),
has
resulted
in
a
global
public
health
crisis,
causing
substantial
concern
especially
to
pregnant
population.
Pregnant
women
infected
with
SARS-CoV-2
are
at
greater
risk
devastating
pregnancy
complications
such
as
premature
delivery
and
stillbirth.
Irrespective
emerging
reported
cases
neonatal
COVID-19,
reassuringly,
confirmatory
evidence
vertical
transmission
is
still
lacking.
protective
role
placenta
limiting
utero
spread
virus
developing
fetus
intriguing.
short-
long-term
impact
maternal
COVID-19
infection
newborn
remains
an
unresolved
question.
In
this
review,
we
explore
recent
transmission,
cell-entry
pathways,
placental
responses
towards
infection,
its
potential
effects
on
offspring.
We
further
discuss
how
serves
defensive
front
against
exerting
various
cellular
molecular
defense
pathways.
A
better
understanding
barrier,
immune
defense,
modulation
strategies
involved
restricting
transplacental
may
provide
valuable
insights
for
future
development
antiviral
immunomodulatory
therapies
improve
outcomes.
BMC Pregnancy and Childbirth,
Год журнала:
2023,
Номер
23(1)
Опубликована: Апрель 22, 2023
Abstract
Background
Pregnant
women
form
a
specially
vulnerable
group
due
to
unique
changes
in
pregnancy,
leading
higher
risk
of
getting
severe
infection.
As
COVID-19
increases
the
preeclampsia,
preterm
delivery,
gestational
diabetes,
and
low
birth
weight
there
is
need
enhance
pregnant
women’s
knowledge,
attitudes,
practices
prevent
these
complications.
This
systematic
review
meta-analysis
aimed
determine
their
levels
practice
(KAP)
regarding
at
global
level.
Methods
The
literature
search
was
conducted
English
language,
including
Google
Scholar,
Scopus,
PubMed/MEDLINE,
Science
Direct,
Web
Science,
EMBASE,
Springer,
ProQuest,
from
occurrence
pandemic
until
September
2022.
We
used
Newcastle
Ottawa
scale
for
cross-sectional
studies
checklist
evaluate
bias
studies.
Data
were
extracted
by
Microsoft
Excel
spreadsheet
analyzed
STATA
software
version
14.
also
employed
Cochran
Q
statistics
assess
heterogeneity
utilized
Inverse
variance
random-effects
models
estimate
pooled
level
KAP
towards
infection
prevention.
Results
Based
on
preferred
reporting
items
reviews
meta-analyses
(PRISMA)
inclusion
criteria,
53
qualified
acquired
several
countries.
In
total,
51
articles
(17,319
participants)
15
(6,509
24
(11,032
included
this
meta-analysis.
good
positive
attitude,
appropriate
estimated
59%(95%CI:
52–66%),
57%(95%CI:
42–72%),
53%(95%CI:
41–65%),
respectively.
According
subgroup
analysis,
61%(95%CI:
49–72),
52%(95%CI:
30–74),
50%(95%CI:
39–60),
respectively,
Africa,
58.8%(95%CI:
49.2–68.4),
60%(95%CI:
41–80)
60%
(95%CI:
41–78),
Asia.
Conclusion
Knowledge,
prevention
low.
It
suggested
that
health
education
programs
empowerment
communities,
especially
women,
about
continue
with
better
planning.
For
future
studies,
we
propose
investigate
countries
other
continents
geographical
regions.
Journal of Reproductive Immunology,
Год журнала:
2024,
Номер
163, С. 104243 - 104243
Опубликована: Март 18, 2024
Associations
between
antenatal
SARS-CoV-2
infection
and
pregnancy
outcomes
have
been
conflicting
the
role
of
immune
system
is
currently
unclear.
This
prospective
cohort
study
investigated
interaction
infection,
changes
in
cytokine
HS-CRP
levels,
birthweight
gestational
age
at
birth.
2,352
pregnant
participants
from
New
York
City
(2020-2022)
were
included.
Plasma
levels
interleukin
(IL)-1β,
IL-6,
IL-17A
high-sensitivity
C-reactive
protein
(HS-CRP)
quantified
blood
specimens
obtained
across
pregnancy.
Quantile
linear
regression
models
conducted
to
1)
assess
impact
overall
by
timing
detection
positivity
(<
20
weeks
versus
≥
weeks),
on
delivery;
2)
examine
relationship
maternal
during
All
adjusted
for
demographic
obstetric
factors
pandemic
timing.
Birthweight
additionally
delivery
fetal
sex.
Immune
marker
also
specimen
collection
multiplex
assay
batch.
371
(15.8%)
infected
with
pregnancy,
which
98
(26.4%)
<
gestation.
Neither
general
nor
early
or
late
was
associated
lower
earlier
delivery.
Further,
we
did
not
observe
response
thus
found
no
evidence
support
a
potential
association
dysregulation
diversity
following
infection.
