Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy

JAMA Network Open, Год журнала: 2023, Номер 6(3), С. e234415 - e234415

Опубликована: Март 23, 2023

Importance Prior studies using large registries have suggested a modest increase in risk for neurodevelopmental diagnoses among children of mothers with immune activation during pregnancy, and such may be sex-specific. Objective To determine whether utero exposure to SARS-CoV-2 is associated sex-specific disorders up 18 months after birth, compared unexposed offspring born or prior the COVID-19 pandemic period. Design, Setting, Participants This retrospective cohort study included live all who delivered between January 1 December 31, 2018 (born followed before pandemic), March 2019 1, 2020, May 2021 pandemic). Offspring were at any 8 hospitals across 2 health systems Massachusetts. Exposures Polymerase chain reaction evidence maternal infection pregnancy. Main Outcomes Measures Electronic record documentation International Statistical Classification Diseases Related Health Problems, Tenth Revision diagnostic codes corresponding disorders. Results The 355 births (9399 boys [51.2%]), including 883 (4.8%) positivity 1809 Asian individuals (9.9%), 1635 Black (8.9%), 12 718 White (69.3%), 1714 (9.3%) other race (American Indian Alaska Native, Native Hawaiian Pacific Islander, more than race); 2617 (14.3%) Hispanic ethnicity. Mean age was 33.0 (IQR, 30.0-36.0) years. In adjusted regression models accounting race, ethnicity, insurance status, hospital type (academic center vs community), age, preterm statistically significant elevation male (adjusted OR, 1.94 [95% CI 1.12-3.17]; P = .01) but not female 0.89 CI, 0.39-1.76]; .77). Similar effects identified matched analyses lieu regression. At months, observed 1.42 0.92-2.11]; .10). Conclusions Relevance this utero, greater magnitude following birth. As infection, substantially larger cohorts longer follow-up will required reliably estimate refute risk.

Язык: Английский

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Effects of intrauterine exposure to SARS-CoV-2 on infants’ development: a rapid review and meta-analysis

European Journal of Pediatrics, Год журнала: 2023, Номер 182(5), С. 2041 - 2055

Опубликована: Март 11, 2023

Язык: Английский

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The Significance of Low Magnesium Levels in COVID-19 Patients

Medicina, Год журнала: 2023, Номер 59(2), С. 279 - 279

Опубликована: Янв. 31, 2023

Magnesium is the fourth most common mineral in human body and second richest intracellular cation. This element necessary for many physiological reactions, especially cardiovascular respiratory systems. COVID-19 an infectious disease caused by SARS-CoV-2. The majority of people who become ill as a result have mild-to-moderate symptoms recover without specific treatment. Moreover, there are develop severe forms COVID-19, which require highly specialized medical assistance. deficiency may play role pathophysiology infection with primary manifestation remains respiratory, but virus can spread to other organs tissues, complicating clinical picture culminating multiorgan failure. key mechanisms involved include direct viral cytotoxicity, endothelial dysfunction, exaggerated release inflammatory cytokines. aim this review was summarize available data regarding magnesium patients its particularities different settings.

Язык: Английский

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Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 24, 2024

Abstract It is unclear if SARS CoV-2 infection during pregnancy associated with adverse neurodevelopmental repercussions to infants. We assessed pediatric outcomes in children born mothers laboratory-confirmed pregnancy. Neurodevelopmental of in-utero exposed were compared that pre-pandemic control Los Angeles (LA), CA, USA and Rio de Janeiro, Brazil. Bayley Scales Infant Toddler Development, 3rd edition (Bayley-III), the gold standard tool for evaluating neurodevelopment until 36 months age Ages Stages Questionnaires (ASQ-3), a frequently used screening instrument this same group assessment tools used. Developmental delay (DD) was defined as having score < − 2 SD below norm (< 70) at least one three Bayley-III domains, (cognitive, motor or language) cut-off (dark zone) five ASQ-3 domains (communication, gross motor, fine problem solving, personal-social). Exposed between April 2020 December 2022 while January 2016 2019. testing performed 300 total: 172 COVID-19 5–30 128 6–38 age. results demonstrated 12 (9.4%) had DD versus controls (1.6%), p = 0.0007. Eight 44 additional on testing. Fully, 20 (11.6%) 0.0006 DD. In Rio, 12% 2.6% controls, 0.02 LA, 5.7% 0 0.12 Severe/critical maternal predicted average cohort (OR 2.6, 95% CI 1.1–6.4). Children antenatal have tenfold higher frequency should be offered follow-up.

Язык: Английский

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Preterm Birth and SARS-CoV-2: Does a Correlation Exist?

Biomedicines, Год журнала: 2025, Номер 13(2), С. 282 - 282

Опубликована: Янв. 24, 2025

Introduction: The emergence of the SARS-CoV-2 virus and its subsequent global pandemic have raised significant concerns regarding impact on pregnancy outcomes. This review aims to summarize emerging data risk preterm delivery in pregnant women infected with SARS-CoV-2. Materials Methods: A systematic search was conducted from March 2020 December 2023 using PubMed Web Science, following PRISMA guidelines. Studies correlating maternal COVID-19 infection birth were included. Results: Thirteen studies analyzed, indicating a higher incidence SARS-CoV-2-positive compared controls. average rate patients 18.5%, median 12.75%, while non-infected showed an 10%, 8.2%. Discussion: suggest association between during increased cesarean section. severity symptoms underlying comorbidities further elevate this risk. Notably, infections third trimester pose highest birth. Conclusion: Preventing is crucial mitigate adverse obstetric Close monitoring tailored interventions for women, particularly those later trimesters comorbidities, are imperative reduce improve maternal-fetal

Язык: Английский

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Emulating Target Trials to Avoid Immortal Time Bias – An Application to Antibiotic Initiation and Preterm Delivery

Epidemiology, Год журнала: 2023, Номер 34(3), С. 430 - 438

Опубликована: Фев. 20, 2023

Background: Randomized trials in pregnancy are extremely challenging, and observational studies often the only option to evaluate medication safety during pregnancy. However, such susceptible immortal time bias if treatment initiation occurs after zero of follow-up. We describe how emulating a sequence target avoids apply approach estimate antibiotic between 24 37 weeks gestation on preterm delivery. Methods: The Tsepamo Study captured birth outcomes at hospitals throughout Botswana from 2014 2021. emulated 13 sequential versus no among individuals presenting care <24 weeks, one for each week weeks. For trial, eligible had not previously initiated antibiotics. also conducted an analysis by defining as exposure calculated adjusted risk ratios (RR) 95% confidence intervals (CI) Results: Of 111,403 individuals, 17,009 (15.3%) antibiotics In trials, RRs (95% CIs) ranged 1.04 (0.90, 1.19) 1.24 (1.11, 1.39) (pooled RR: 1.11 [1.06, 1.15]). bias, RR was 0.90 (0.86, 0.94). Conclusions: Defining any follow-up resulted substantial making appear protective against Conducting can avoid studies.

Язык: Английский

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SARS-CoV-2 Transplacental Transmission: A Rare Occurrence? An Overview of the Protective Role of the Placenta

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4550 - 4550

Опубликована: Фев. 25, 2023

The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel severe acute respiratory syndrome 2 (SARS-CoV-2), has resulted in a global public health crisis, causing substantial concern especially to pregnant population. Pregnant women infected with SARS-CoV-2 are at greater risk devastating pregnancy complications such as premature delivery and stillbirth. Irrespective emerging reported cases neonatal COVID-19, reassuringly, confirmatory evidence vertical transmission is still lacking. protective role placenta limiting utero spread virus developing fetus intriguing. short- long-term impact maternal COVID-19 infection newborn remains an unresolved question. In this review, we explore recent transmission, cell-entry pathways, placental responses towards infection, its potential effects on offspring. We further discuss how serves defensive front against exerting various cellular molecular defense pathways. A better understanding barrier, immune defense, modulation strategies involved restricting transplacental may provide valuable insights for future development antiviral immunomodulatory therapies improve outcomes.

Язык: Английский

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Global knowledge, attitude, and practice towards COVID-19 among pregnant women: a systematic review and meta-analysis

BMC Pregnancy and Childbirth, Год журнала: 2023, Номер 23(1)

Опубликована: Апрель 22, 2023

Abstract Background Pregnant women form a specially vulnerable group due to unique changes in pregnancy, leading higher risk of getting severe infection. As COVID-19 increases the preeclampsia, preterm delivery, gestational diabetes, and low birth weight there is need enhance pregnant women’s knowledge, attitudes, practices prevent these complications. This systematic review meta-analysis aimed determine their levels practice (KAP) regarding at global level. Methods The literature search was conducted English language, including Google Scholar, Scopus, PubMed/MEDLINE, Science Direct, Web Science, EMBASE, Springer, ProQuest, from occurrence pandemic until September 2022. We used Newcastle Ottawa scale for cross-sectional studies checklist evaluate bias studies. Data were extracted by Microsoft Excel spreadsheet analyzed STATA software version 14. also employed Cochran Q statistics assess heterogeneity utilized Inverse variance random-effects models estimate pooled level KAP towards infection prevention. Results Based on preferred reporting items reviews meta-analyses (PRISMA) inclusion criteria, 53 qualified acquired several countries. In total, 51 articles (17,319 participants) 15 (6,509 24 (11,032 included this meta-analysis. good positive attitude, appropriate estimated 59%(95%CI: 52–66%), 57%(95%CI: 42–72%), 53%(95%CI: 41–65%), respectively. According subgroup analysis, 61%(95%CI: 49–72), 52%(95%CI: 30–74), 50%(95%CI: 39–60), respectively, Africa, 58.8%(95%CI: 49.2–68.4), 60%(95%CI: 41–80) 60% (95%CI: 41–78), Asia. Conclusion Knowledge, prevention low. It suggested that health education programs empowerment communities, especially women, about continue with better planning. For future studies, we propose investigate countries other continents geographical regions.

Язык: Английский

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SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort

Journal of Reproductive Immunology, Год журнала: 2024, Номер 163, С. 104243 - 104243

Опубликована: Март 18, 2024

Associations between antenatal SARS-CoV-2 infection and pregnancy outcomes have been conflicting the role of immune system is currently unclear. This prospective cohort study investigated interaction infection, changes in cytokine HS-CRP levels, birthweight gestational age at birth. 2,352 pregnant participants from New York City (2020-2022) were included. Plasma levels interleukin (IL)-1β, IL-6, IL-17A high-sensitivity C-reactive protein (HS-CRP) quantified blood specimens obtained across pregnancy. Quantile linear regression models conducted to 1) assess impact overall by timing detection positivity (< 20 weeks versus ≥ weeks), on delivery; 2) examine relationship maternal during All adjusted for demographic obstetric factors pandemic timing. Birthweight additionally delivery fetal sex. Immune marker also specimen collection multiplex assay batch. 371 (15.8%) infected with pregnancy, which 98 (26.4%) < gestation. Neither general nor early or late was associated lower earlier delivery. Further, we did not observe response thus found no evidence support a potential association dysregulation diversity following infection.

Язык: Английский

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COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study

The Lancet Regional Health - Europe, Год журнала: 2024, Номер 45, С. 101037 - 101037

Опубликована: Авг. 23, 2024

Язык: Английский

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