Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 43
Published: Jan. 1, 2024
Language: Английский
JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(3), P. e234415 - e234415
Published: March 23, 2023
Importance Prior studies using large registries have suggested a modest increase in risk for neurodevelopmental diagnoses among children of mothers with immune activation during pregnancy, and such may be sex-specific. Objective To determine whether utero exposure to SARS-CoV-2 is associated sex-specific disorders up 18 months after birth, compared unexposed offspring born or prior the COVID-19 pandemic period. Design, Setting, Participants This retrospective cohort study included live all who delivered between January 1 December 31, 2018 (born followed before pandemic), March 2019 1, 2020, May 2021 pandemic). Offspring were at any 8 hospitals across 2 health systems Massachusetts. Exposures Polymerase chain reaction evidence maternal infection pregnancy. Main Outcomes Measures Electronic record documentation International Statistical Classification Diseases Related Health Problems, Tenth Revision diagnostic codes corresponding disorders. Results The 355 births (9399 boys [51.2%]), including 883 (4.8%) positivity 1809 Asian individuals (9.9%), 1635 Black (8.9%), 12 718 White (69.3%), 1714 (9.3%) other race (American Indian Alaska Native, Native Hawaiian Pacific Islander, more than race); 2617 (14.3%) Hispanic ethnicity. Mean age was 33.0 (IQR, 30.0-36.0) years. In adjusted regression models accounting race, ethnicity, insurance status, hospital type (academic center vs community), age, preterm statistically significant elevation male (adjusted OR, 1.94 [95% CI 1.12-3.17]; P = .01) but not female 0.89 CI, 0.39-1.76]; .77). Similar effects identified matched analyses lieu regression. At months, observed 1.42 0.92-2.11]; .10). Conclusions Relevance this utero, greater magnitude following birth. As infection, substantially larger cohorts longer follow-up will required reliably estimate refute risk.
Language: Английский
Citations
53
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: May 24, 2024
Abstract It is unclear if SARS CoV-2 infection during pregnancy associated with adverse neurodevelopmental repercussions to infants. We assessed pediatric outcomes in children born mothers laboratory-confirmed pregnancy. Neurodevelopmental of in-utero exposed were compared that pre-pandemic control Los Angeles (LA), CA, USA and Rio de Janeiro, Brazil. Bayley Scales Infant Toddler Development, 3rd edition (Bayley-III), the gold standard tool for evaluating neurodevelopment until 36 months age Ages Stages Questionnaires (ASQ-3), a frequently used screening instrument this same group assessment tools used. Developmental delay (DD) was defined as having score < − 2 SD below norm (< 70) at least one three Bayley-III domains, (cognitive, motor or language) cut-off (dark zone) five ASQ-3 domains (communication, gross motor, fine problem solving, personal-social). Exposed between April 2020 December 2022 while January 2016 2019. testing performed 300 total: 172 COVID-19 5–30 128 6–38 age. results demonstrated 12 (9.4%) had DD versus controls (1.6%), p = 0.0007. Eight 44 additional on testing. Fully, 20 (11.6%) 0.0006 DD. In Rio, 12% 2.6% controls, 0.02 LA, 5.7% 0 0.12 Severe/critical maternal predicted average cohort (OR 2.6, 95% CI 1.1–6.4). Children antenatal have tenfold higher frequency should be offered follow-up.
Language: Английский
Citations
9
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 282 - 282
Published: Jan. 24, 2025
Introduction: The emergence of the SARS-CoV-2 virus and its subsequent global pandemic have raised significant concerns regarding impact on pregnancy outcomes. This review aims to summarize emerging data risk preterm delivery in pregnant women infected with SARS-CoV-2. Materials Methods: A systematic search was conducted from March 2020 December 2023 using PubMed Web Science, following PRISMA guidelines. Studies correlating maternal COVID-19 infection birth were included. Results: Thirteen studies analyzed, indicating a higher incidence SARS-CoV-2-positive compared controls. average rate patients 18.5%, median 12.75%, while non-infected showed an 10%, 8.2%. Discussion: suggest association between during increased cesarean section. severity symptoms underlying comorbidities further elevate this risk. Notably, infections third trimester pose highest birth. Conclusion: Preventing is crucial mitigate adverse obstetric Close monitoring tailored interventions for women, particularly those later trimesters comorbidities, are imperative reduce improve maternal-fetal
Language: Английский
Citations
1
European Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 182(5), P. 2041 - 2055
Published: March 11, 2023
Language: Английский
Citations
22
Medicina, Journal Year: 2023, Volume and Issue: 59(2), P. 279 - 279
Published: Jan. 31, 2023
Magnesium is the fourth most common mineral in human body and second richest intracellular cation. This element necessary for many physiological reactions, especially cardiovascular respiratory systems. COVID-19 an infectious disease caused by SARS-CoV-2. The majority of people who become ill as a result have mild-to-moderate symptoms recover without specific treatment. Moreover, there are develop severe forms COVID-19, which require highly specialized medical assistance. deficiency may play role pathophysiology infection with primary manifestation remains respiratory, but virus can spread to other organs tissues, complicating clinical picture culminating multiorgan failure. key mechanisms involved include direct viral cytotoxicity, endothelial dysfunction, exaggerated release inflammatory cytokines. aim this review was summarize available data regarding magnesium patients its particularities different settings.
Language: Английский
Citations
19
Epidemiology, Journal Year: 2023, Volume and Issue: 34(3), P. 430 - 438
Published: Feb. 20, 2023
Background: Randomized trials in pregnancy are extremely challenging, and observational studies often the only option to evaluate medication safety during pregnancy. However, such susceptible immortal time bias if treatment initiation occurs after zero of follow-up. We describe how emulating a sequence target avoids apply approach estimate antibiotic between 24 37 weeks gestation on preterm delivery. Methods: The Tsepamo Study captured birth outcomes at hospitals throughout Botswana from 2014 2021. emulated 13 sequential versus no among individuals presenting care <24 weeks, one for each week weeks. For trial, eligible had not previously initiated antibiotics. also conducted an analysis by defining as exposure calculated adjusted risk ratios (RR) 95% confidence intervals (CI) Results: Of 111,403 individuals, 17,009 (15.3%) antibiotics In trials, RRs (95% CIs) ranged 1.04 (0.90, 1.19) 1.24 (1.11, 1.39) (pooled RR: 1.11 [1.06, 1.15]). bias, RR was 0.90 (0.86, 0.94). Conclusions: Defining any follow-up resulted substantial making appear protective against Conducting can avoid studies.
Language: Английский
Citations
15
Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 163, P. 104243 - 104243
Published: March 18, 2024
Associations between antenatal SARS-CoV-2 infection and pregnancy outcomes have been conflicting the role of immune system is currently unclear. This prospective cohort study investigated interaction infection, changes in cytokine HS-CRP levels, birthweight gestational age at birth. 2,352 pregnant participants from New York City (2020-2022) were included. Plasma levels interleukin (IL)-1β, IL-6, IL-17A high-sensitivity C-reactive protein (HS-CRP) quantified blood specimens obtained across pregnancy. Quantile linear regression models conducted to 1) assess impact overall by timing detection positivity (< 20 weeks versus ≥ weeks), on delivery; 2) examine relationship maternal during All adjusted for demographic obstetric factors pandemic timing. Birthweight additionally delivery fetal sex. Immune marker also specimen collection multiplex assay batch. 371 (15.8%) infected with pregnancy, which 98 (26.4%) < gestation. Neither general nor early or late was associated lower earlier delivery. Further, we did not observe response thus found no evidence support a potential association dysregulation diversity following infection.
Language: Английский
Citations
4
The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 45, P. 101037 - 101037
Published: Aug. 23, 2024
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4550 - 4550
Published: Feb. 25, 2023
The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel severe acute respiratory syndrome 2 (SARS-CoV-2), has resulted in a global public health crisis, causing substantial concern especially to pregnant population. Pregnant women infected with SARS-CoV-2 are at greater risk devastating pregnancy complications such as premature delivery and stillbirth. Irrespective emerging reported cases neonatal COVID-19, reassuringly, confirmatory evidence vertical transmission is still lacking. protective role placenta limiting utero spread virus developing fetus intriguing. short- long-term impact maternal COVID-19 infection newborn remains an unresolved question. In this review, we explore recent transmission, cell-entry pathways, placental responses towards infection, its potential effects on offspring. We further discuss how serves defensive front against exerting various cellular molecular defense pathways. A better understanding barrier, immune defense, modulation strategies involved restricting transplacental may provide valuable insights for future development antiviral immunomodulatory therapies improve outcomes.
Language: Английский
Citations
11
BMC Pregnancy and Childbirth, Journal Year: 2023, Volume and Issue: 23(1)
Published: April 22, 2023
Abstract Background Pregnant women form a specially vulnerable group due to unique changes in pregnancy, leading higher risk of getting severe infection. As COVID-19 increases the preeclampsia, preterm delivery, gestational diabetes, and low birth weight there is need enhance pregnant women’s knowledge, attitudes, practices prevent these complications. This systematic review meta-analysis aimed determine their levels practice (KAP) regarding at global level. Methods The literature search was conducted English language, including Google Scholar, Scopus, PubMed/MEDLINE, Science Direct, Web Science, EMBASE, Springer, ProQuest, from occurrence pandemic until September 2022. We used Newcastle Ottawa scale for cross-sectional studies checklist evaluate bias studies. Data were extracted by Microsoft Excel spreadsheet analyzed STATA software version 14. also employed Cochran Q statistics assess heterogeneity utilized Inverse variance random-effects models estimate pooled level KAP towards infection prevention. Results Based on preferred reporting items reviews meta-analyses (PRISMA) inclusion criteria, 53 qualified acquired several countries. In total, 51 articles (17,319 participants) 15 (6,509 24 (11,032 included this meta-analysis. good positive attitude, appropriate estimated 59%(95%CI: 52–66%), 57%(95%CI: 42–72%), 53%(95%CI: 41–65%), respectively. According subgroup analysis, 61%(95%CI: 49–72), 52%(95%CI: 30–74), 50%(95%CI: 39–60), respectively, Africa, 58.8%(95%CI: 49.2–68.4), 60%(95%CI: 41–80) 60% (95%CI: 41–78), Asia. Conclusion Knowledge, prevention low. It suggested that health education programs empowerment communities, especially women, about continue with better planning. For future studies, we propose investigate countries other continents geographical regions.
Language: Английский
Citations
11