Gut Microbiota and Hepatocellular Carcinoma: Metabolic Products and Immunotherapy Modulation
Cancer Medicine,
Год журнала:
2025,
Номер
14(9)
Опубликована: Май 1, 2025
ABSTRACT
Background
The
relationship
between
hepatocellular
carcinoma
(HCC)
and
gut
microbiota
has
gained
attention
for
its
impact
on
HCC
immunotherapy.
Methods
Key
microbial
metabolites,
including
bile
acids,
toll‐like
receptor
4,
short‐chain
fatty
bacterial
toxins,
contribute
to
progression
influence
immune
responses
through
the
gut‐liver
axis.
As
checkpoint
inhibitors
(ICIs)
become
common
in
treatment,
modulating
offers
new
strategies
enhance
ICIs
efficacy.
However,
individual
differences
composition
introduce
challenges,
with
some
patients
showing
resistance
ICIs.
Results
This
review
summarizes
latest
findings
role
of
explores
emerging
therapeutic
approaches,
fecal
transplantation,
probiotics,
antibiotics,
natural
compounds.
Conclusions
focus
is
translating
these
insights
into
personalized
medicine
optimize
improve
treatment
outcomes.
Язык: Английский
The immunosuppressive role of MDSCs in HCC: mechanisms and therapeutic opportunities
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 27, 2025
Hepatocellular
carcinoma
(HCC)
is
a
prevalent
malignancy
with
significant
global
burden.
Despite
substantial
advancements
in
HCC
treatment
recent
years,
therapeutic
efficacy
remains
constrained
by
immune
evasion
mechanisms
within
the
tumor
microenvironment
(TME).
Myeloid-derived
suppressor
cells
(MDSCs),
as
critical
immunosuppressive
elements
of
TME,
have
garnered
increasing
attention
for
their
role
progression.
Recent
studies
emphasize
central
involvement
promoting
evasion,
tolerance,
and
immunosuppression
HCC.
This
review
examines
contributions
MDSCs
to
pathogenesis,
elucidates
underlying
mechanisms,
discusses
ongoing
clinical
trials,
emphasizing
potential
targets
improving
outcomes.
Язык: Английский
Rising Incidence of Early-Onset Liver Cancer and Intrahepatic Bile Duct Cancer: Analysis of the National Childhood Cancer Registry Database
Cancers,
Год журнала:
2025,
Номер
17(7), С. 1133 - 1133
Опубликована: Март 28, 2025
Background/Objectives:
Early-onset
cancer
is
an
emerging
global
health
concern,
including
in
the
United
States.
However,
data
on
early-onset
liver
and
intrahepatic
bile
duct
remain
limited.
This
study
aims
to
fill
this
gap
by
analyzing
trends
States
over
past
two
decades.
Methods:
used
National
Childhood
Cancer
Registry
examine
temporal
The
analysis
involved
estimating
age-adjusted
incidence
rates
of
cancer,
stratified
histological
type,
ethnicity,
sex.
Results:
In
2021,
rate
was
estimated
at
0.53
per
100,000
population
(95%
Confidence
Interval
[CI]:
0.48-0.59).
From
2001
showed
a
significant
annual
percent
change
(APC)
1.35%
CI:
0.87-1.83%).
When
sex,
females
increased
significantly
(APC:
3.07%,
95%
2.26-3.87%)
while
remaining
stable
males.
Among
racial
ethnic
groups,
non-Hispanic
American
Indian
Alaska
Native
(AIAN)
individuals
had
highest
rate,
recorded
2.67
0.95-5.85).
By
hepatic
carcinoma
increasing
time
1.47%,
0.96-1.99%).
contrast,
for
hepatoblastoma
unspecified
tumors
remained
between
2021.
Conclusions:
Our
identified
States,
primarily
driven
cases
carcinoma.
Язык: Английский
Assessing the effect of modifiable risk factors on hepatocellular carcinoma: evidence from a bidirectional Mendelian randomization analysis
Discover Oncology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 31, 2025
The
pathogenesis
of
hepatocellular
carcinoma
(HCC)
involves
a
variety
environmental
risk
factors,
some
which
have
yet
to
be
fully
clarified.
Using
the
Mendelian
randomization
(MR)
approach,
this
study
comprehensively
investigates
causal
effect
genetically
predicted
modifiable
factors
on
HCC.
Genetic
variants
related
50
that
had
been
identified
in
previous
research
were
derived
from
genome-wide
association
studies.
Summary
statistics
for
discovery
cohort
and
validation
HCC
sourced
FinnGen
consortium
UK
Biobank,
respectively.
Bidirectional
MR
analysis
sensitivity
performed
establish
causative
Through
inverse
variance
weighted
method,
results
indicated
waist
circumference,
nonalcoholic
fatty
liver
disease
(NAFLD),
alanine
aminotransferase
(ALT)
levels,
aspartate
(AST)
levels
significantly
linked
occurrence
risk.
Furthermore,
body
fat
percentage,
glycated
hemoglobin
(HbA1c),
obesity
class
1-3,
waist-to-hip
ratio,
iron,
ferritin,
transferrin
saturation,
urate
suggestive
associations
with
further
confirmed
NAFLD
ALT
strongly
Reverse
genetic
susceptibility
was
connected
saturation.
Sensitivity
analyses
showed
most
findings
robust.
This
delivers
evidence
complex
relationship
between
These
offer
new
insights
into
potential
prevention
treatment
strategies
Язык: Английский