“Bridging Microbiomes: Exploring Oral and Gut Microbiomes in Autoimmune Thyroid Diseases- New Insights and Therapeutic Frontiers
Gut Microbes Reports,
Год журнала:
2025,
Номер
unknown, С. 1 - 20
Опубликована: Янв. 15, 2025
Autoimmune
thyroid
diseases
(AITDs)
are
the
most
common
organ-specific
autoimmune
disorders
characterized
by
dysfunction
and
immune
system
deficiencies.
In
recent
decades,
role
of
microbiome
in
has
gained
increasing
attention,
with
emerging
research
linking
gut
alterations
to
development
AITDs.
This
review
summarizes
current
knowledge
on
relationship
between
AITDs
microbiome.
Additionally,
it
emphasizes
oral
AITDs,
an
area
often
overlooked
research.
Beyond
microbiome,
virome
mycobiome
have
been
recognized
as
critical
but
underexplored
components
human
potentially
contributing
dysregulation
pathogenesis
The
also
explores
modulating
for
managing
including
diet
adjustment,
potential
use
probiotics,
postbiotics,
symbiotics,
even
fecal
microbiota
transplantation
(FMT)
restore
a
balanced
that
may
positively
influence
and,
extension,
course
thoroughly
intricate
gut,
microbiomes,
paving
way
precision
medicine
applications
Examining
microbiota-thyroid
interactions
highlights
targeted,
personalized
treatments
novel
therapeutic
therapies,
guiding
future
strategies
more
effective
precisely
tailored
AITD
management
approaches.
Язык: Английский
The role of oxidative stress in the development of autoimmune thyroiditis: current state of the problem (literature review)
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Год журнала:
2025,
Номер
21(1), С. 77 - 81
Опубликована: Фев. 23, 2025
The
review
article
examines
the
issues
of
autoimmune
thyroiditis
(AIT)
pathogenesis.
Analysis
current
scientific
data
revealed
an
increase
in
number
cases
this
disease
(6–11
%
worldwide
among
adult
population),
and
need
for
further
research
to
understand
its
etiology,
diagnosis
treatment
is
emerging.
This
considers
oxidative
stress
that
accumulation
active
harmful
agents
(free
radicals,
prooxidants,
reactive
oxygen
species),
which
initiate
cell
damage
lead
development
various
pathological
conditions.
study
on
mechanism
free-radical
caused
by
species
will
open
opportunities
introduction
optimization
antioxidant
therapy
patients
with
AIT
order
slow
down
progression
disease.
In
occurrence
thyroid
cells,
formation
antibodies
lymphocytic
infiltration
gland
play
important
role.
It
has
been
noted
genetic
factors
precede
changes.
Loss
immune
tolerance
autoantigens
such
as
peroxidase
(TPO),
thyroglobulin
(TG)
basis
development
AIT.
role
pathogenesis
noted.
shown
at
onset,
asymptomatic,
TPO
TG
precedes
may
indicate
latent
prevalence
varies
different
countries
world
ranges
from
2
20
%,
women,
it
was
4–6
times
higher
than
men.
Over
time,
turns
into
subclinical
overt
hypothyroidism.
incidence
27
273
per
100,000
population.
Diagnosis
made
clinical
signs,
positivity
serum
against
TPO,
cytological
examination.
main
direction
management
hypothyroidism
hormone
replacement
therapy.
A
relationship
between
a
possible
malignant
transformation
suggested
several
studies
involves
immunological/hormonal
pathogenic
links
although
specific
correlation
still
debated
needs
be
investigated
prospective
studies.
Язык: Английский
No Association Between Diet Quality, Nutritional Status, and Quality of Life in Women with Hashimoto’s Thyroiditis—A Cross-Sectional Study
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 1015 - 1015
Опубликована: Март 14, 2025
Objectives:
Dietary
habits
are
identified
as
a
potential
factor
influencing
the
quality
of
life
individuals
diagnosed
with
Hashimoto’s
disease
(HAT).
The
objective
this
study
was
to
analyze
relationship
between
diet
and
selected
parameters
nutritional
status,
in
female
patients
HAT.
Methods:
A
descriptive
cross-sectional
conducted
among
147
women
aged
39.9
±
10.39
years.
Diet
determined
Pro-Healthy
Index
(pHDI-10),
thyroid-specific
questionnaire
(ThyPROpl),
gastrointestinal
symptoms
Gastrointestinal
Symptom
Rating
Scale
(GSRS).
Results:
mean
pHDI-10
score
25.5
9.59;
80%
had
low
pro-healthy
(LQD
group,
21.9
6,89
pts.)
20%
medium
(MQD
39.7
4.69
pts.).
Nutritional
status
anthropometric
health
risk
did
not
differ
groups.
ThyPROpl
49.15
31.16
(LQD:
49.58
31.01,
MQD:
47.41
32.28,
p
=
0.73).
Conclusions:
Quality
associated
or
HAT
patients.
However,
majority
participants
showed
poor
healthy
eating
habits,
elevated
body
mass
index
unsatisfactory
areas,
such
tiredness,
hypothyroid
symptoms,
depression,
emotional
vulnerability,
anxiety.
Язык: Английский
Unlocking the Power of the Mediterranean Diet: Two in One—Dual Benefits for Rheumatic and Thyroid Autoimmune Diseases
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1383 - 1383
Опубликована: Апрель 19, 2025
In
recent
years,
autoimmune
diseases
are
becoming
more
and
prevalent
worldwide,
with
this
rapid
rise
being
influenced
by
environmental
factors
linked
to
lifestyle
changes
in
modern
societies.
context,
the
role
of
diet
has
been
topic
extensive
research
as
evidence
mounted
that
particular
dietary
patterns
may
contribute
or
modulate
autoimmunity.
The
present
review
specifically
focuses
on
Mediterranean
(MD)
a
whole
pattern,
its
peculiar
components,
such
n-3
polyunsaturated
fatty
acids
(PUFAs),
polyphenols
fiber.
We
explored
their
potential
benefits
spectrum
both
systemic
organ-specific
disorders,
including
rheumatic
(like
arthritis
lupus
erythematosus),
thyroid
Hashimoto’s
thyroiditis),
since
they
often
occur
same
individuals.
Here,
we
offer
comprehensive
about
influence
these
translation
into
therapeutic
interventions,
an
adjuvant
approach
improve
autoimmunity-related
outcomes.
Язык: Английский