“Bridging Microbiomes: Exploring Oral and Gut Microbiomes in Autoimmune Thyroid Diseases- New Insights and Therapeutic Frontiers

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Jan. 15, 2025

Autoimmune thyroid diseases (AITDs) are the most common organ-specific autoimmune disorders characterized by dysfunction and immune system deficiencies. In recent decades, role of microbiome in has gained increasing attention, with emerging research linking gut alterations to development AITDs. This review summarizes current knowledge on relationship between AITDs microbiome. Additionally, it emphasizes oral AITDs, an area often overlooked research. Beyond microbiome, virome mycobiome have been recognized as critical but underexplored components human potentially contributing dysregulation pathogenesis The also explores modulating for managing including diet adjustment, potential use probiotics, postbiotics, symbiotics, even fecal microbiota transplantation (FMT) restore a balanced that may positively influence and, extension, course thoroughly intricate gut, microbiomes, paving way precision medicine applications Examining microbiota-thyroid interactions highlights targeted, personalized treatments novel therapeutic therapies, guiding future strategies more effective precisely tailored AITD management approaches.

Language: Английский

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The role of oxidative stress in the development of autoimmune thyroiditis: current state of the problem (literature review)

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(1), P. 77 - 81

Published: Feb. 23, 2025

The review article examines the issues of autoimmune thyroiditis (AIT) pathogenesis. Analysis current scientific data revealed an increase in number cases this disease (6–11 % worldwide among adult population), and need for further research to understand its etiology, diagnosis treatment is emerging. This considers oxidative stress that accumulation active harmful agents (free radicals, prooxidants, reactive oxygen species), which initiate cell damage lead development various pathological conditions. study on mechanism free-radical caused by species will open opportunities introduction optimization antioxidant therapy patients with AIT order slow down progression disease. In occurrence thyroid cells, formation antibodies lymphocytic infiltration gland play important role. It has been noted genetic factors precede changes. Loss immune tolerance autoantigens such as peroxidase (TPO), thyroglobulin (TG) basis deve­lopment AIT. role pathogenesis noted. shown at onset, asymptomatic, TPO TG precedes may indicate latent prevalence varies different countries world ranges from 2 20 %, women, it was 4–6 times higher than men. Over time, turns into subclinical overt hypothyroidism. incidence 27 273 per 100,000 population. Diagnosis made clinical signs, positivity serum against TPO, cytological examination. main direction management hypothyroidism hormone replacement therapy. A relationship between a possible malignant transformation suggested several studies involves immunological/hormonal pathogenic links although specific correlation still debated needs be investigated prospective studies.

Language: Английский

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No Association Between Diet Quality, Nutritional Status, and Quality of Life in Women with Hashimoto’s Thyroiditis—A Cross-Sectional Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1015 - 1015

Published: March 14, 2025

Objectives: Dietary habits are identified as a potential factor influencing the quality of life individuals diagnosed with Hashimoto’s disease (HAT). The objective this study was to analyze relationship between diet and selected parameters nutritional status, in female patients HAT. Methods: A descriptive cross-sectional conducted among 147 women aged 39.9 ± 10.39 years. Diet determined Pro-Healthy Index (pHDI-10), thyroid-specific questionnaire (ThyPROpl), gastrointestinal symptoms Gastrointestinal Symptom Rating Scale (GSRS). Results: mean pHDI-10 score 25.5 9.59; 80% had low pro-healthy (LQD group, 21.9 6,89 pts.) 20% medium (MQD 39.7 4.69 pts.). Nutritional status anthropometric health risk did not differ groups. ThyPROpl 49.15 31.16 (LQD: 49.58 31.01, MQD: 47.41 32.28, p = 0.73). Conclusions: Quality associated or HAT patients. However, majority participants showed poor healthy eating habits, elevated body mass index unsatisfactory areas, such tiredness, hypothyroid symptoms, depression, emotional vulnerability, anxiety.

Language: Английский

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Unlocking the Power of the Mediterranean Diet: Two in One—Dual Benefits for Rheumatic and Thyroid Autoimmune Diseases

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1383 - 1383

Published: April 19, 2025

In recent years, autoimmune diseases are becoming more and prevalent worldwide, with this rapid rise being influenced by environmental factors linked to lifestyle changes in modern societies. context, the role of diet has been topic extensive research as evidence mounted that particular dietary patterns may contribute or modulate autoimmunity. The present review specifically focuses on Mediterranean (MD) a whole pattern, its peculiar components, such n-3 polyunsaturated fatty acids (PUFAs), polyphenols fiber. We explored their potential benefits spectrum both systemic organ-specific disorders, including rheumatic (like arthritis lupus erythematosus), thyroid Hashimoto’s thyroiditis), since they often occur same individuals. Here, we offer comprehensive about influence these translation into therapeutic interventions, an adjuvant approach improve autoimmunity-related outcomes.

Language: Английский

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