Effect of Gamma Radiation on Human Enemal Chemical and Pshysical Properties DOI Creative Commons

Pollyanna Nogueira Ferreira da Silva,

Maria Carolina Fernandes Barcellos, F. A. L. Costa

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Background: Gamma radiation is still used in developing countries for head and neck cancer treatment. Irradiated dental enamel undergoes dose-dependent chemical mechanical changes that can hinder oral rehabilitation. Understanding these processes be useful to professionals plan safer long-lasting treatments. This study aimed evaluate different doses of gamma on the properties human enamel. Methods: Sixty third molars were divided into six groups (n = 10), according dose: 0; 20; 40; 50; 60; or 70 Gy, daily increments 2 Gy. After irradiation, composition carbonate/ phosphate ratio (C:P) evaluated by Fourier Transformed Infrared Spectroscopy (FTIR). X-ray diffraction (XRD) was crystal size (shape factor) crystallinity. Hardness, elastic modulus, scratch resistance measured, microstructure observed scanning electron microscopy (SEM). Data C:P, crystallinity (%), shape factor (nm), hardness (VHN - Vickers Hardness Number), modulus (GPa Gigapascals) submitted analysis variance Tukey's test (α=0.05). Results: FTIR showed carboxylic acid irradiated an increase C:P Gy group (p 0.015), but with no change crystalline structure. A significant decrease values (p=0.0000) groups. For test, 60 70Gy lower initial spallation. SEM spaced rounded peaks prisms Conclusions: negatively affected physical Trial registration: Plataforma Brasil, CAAE: 66495417.1.0000.007.

Язык: Английский

Dynamic Changes of Dental Plaque and Saliva Microbiota in OSCC Progression DOI Creative Commons
Man Zhang, Hailin Zhang,

Hong Ao

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Objectives To elucidate the microbial and genomic changes in saliva dental plaque during Oral Squamous Cell Carcinoma (OSCC) progression, to identify potential mechanisms virulence factors involved OSCC pathogenesis. Materials Methods Using metagenomic sequencing, 64 samples from patients at different stages of differentiation were examined. Results The results showed notable differences composition profiles across ecological regions degrees. Notably, relative abundance specific microbes, such as Porphyromonas gingivalis, Fusobacterium nucleatum, Haemophilus parainfluenzae, increased poorly differentiated OSCC. Microbial alpha diversity correlates with tumor T staging. Dental microbiota shows higher specialization, especially tumors. Both types become more stable advanced Genomic analysis reveals stages. Subsequently, functional pathway tracing pathogens reveal oral cancer may promote tumorigenesis by secreting like GAPDH, GspG, AllS, drive initiation progression through interactions. Conclusions is associated altered composition, diversity, plaque. Poorly show factors, implicating them tumorigenesis. Clinical Relevance Understanding could help develop new diagnostic biomarkers therapies targeting microbiota, potentially improving early detection, treatment efficacy, prognosis for patients. Maintaining microbiome homeostasis also prevent cancer.

Язык: Английский

Процитировано

0
Potential causal association between the oral microbiome and bipolar disorder DOI
Jing Li, Jun Chen, Jiwen Li

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Development and Evaluation of the Biological Activities of a Plain Mucoadhesive Hydrogel as a Potential Vehicle for Oral Mucosal Drug Delivery DOI Creative Commons

Ana G. Pardo-Rendón,

Jorge L. Mejía-Méndez, Edgar R. López-Mena

и другие.

Gels, Год журнала: 2024, Номер 10(9), С. 574 - 574

Опубликована: Сен. 3, 2024

This study aimed to develop HGs based on cationic guar gum (CGG), polyethylene glycol (PEG), propylene (PG), and citric acid (CA) using a 2

Язык: Английский

Процитировано

2
Effect of Gamma Radiation on Human Enemal Chemical and Pshysical Properties DOI Creative Commons

Pollyanna Nogueira Ferreira da Silva,

Maria Carolina Fernandes Barcellos, F. A. L. Costa

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Background: Gamma radiation is still used in developing countries for head and neck cancer treatment. Irradiated dental enamel undergoes dose-dependent chemical mechanical changes that can hinder oral rehabilitation. Understanding these processes be useful to professionals plan safer long-lasting treatments. This study aimed evaluate different doses of gamma on the properties human enamel. Methods: Sixty third molars were divided into six groups (n = 10), according dose: 0; 20; 40; 50; 60; or 70 Gy, daily increments 2 Gy. After irradiation, composition carbonate/ phosphate ratio (C:P) evaluated by Fourier Transformed Infrared Spectroscopy (FTIR). X-ray diffraction (XRD) was crystal size (shape factor) crystallinity. Hardness, elastic modulus, scratch resistance measured, microstructure observed scanning electron microscopy (SEM). Data C:P, crystallinity (%), shape factor (nm), hardness (VHN - Vickers Hardness Number), modulus (GPa Gigapascals) submitted analysis variance Tukey's test (α=0.05). Results: FTIR showed carboxylic acid irradiated an increase C:P Gy group (p 0.015), but with no change crystalline structure. A significant decrease values (p=0.0000) groups. For test, 60 70Gy lower initial spallation. SEM spaced rounded peaks prisms Conclusions: negatively affected physical Trial registration: Plataforma Brasil, CAAE: 66495417.1.0000.007.

Язык: Английский

Процитировано

0