Evaluating the antibacterial effect of meropenem-loaded chitosan/sodium tripolyphosphate (TPP) nanoparticles on Acinetobacter baumannii isolated from hospitalized patients

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 24, 2024

Abstract Background Acinetobacter baumannii is a health threat due to its antibiotic resistance. Herein, susceptibility and association with the Toxin-antitoxin (TA) system genes in A. clinical isolates from Iran were investigated. Next, we prepared meropenem-loaded chitosan nanoparticles (MP-CS) investigated their antibacterial effects against meropenem-susceptible bacterial isolates. Methods Out of 240 specimens, 60 assessed. Antibiotic resistance conventional antibiotics was determined alongside investigating presence three TA ( mazEF , relBE higBA ). Chitosan characterized terms size, zeta potential, encapsulation efficiency, meropenem release activity. Their assessed using well diffusion method, minimum inhibitory concentration (MIC), colony-forming unit (CFU) counting. cytotoxic biocompatibility index via MTT, LDH, ROS formation assays. Results Ampicillin, ceftazidime, colistin least effective, amikacin tobramycin most effective antibiotics. isolates, 10 (16.7%), 5 (8.3%), 45 (75%) multidrug-resistant (MDR), extensively drug-resistant (XDR), pandrug-resistant (PDR), respectively. had no significant effect on MP-CS demonstrated an average size 191.5 potential 27.3 mV maximum efficiency 88.32% rate 69.57%. mediated similar effects, as compared free meropenem, significantly lower levels meropenem. remarkably prevented A549 NCI-H292 cell infection by demonstrating favorable index. Conclusion Antibiotic-loaded should be further designed increase assess safety applicability vivo settings.

Язык: Английский

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Berberine-loaded albumin nanoparticles alleviate liver damage in rats by modulating mitochondrial biogenesis and mitochondria-endoplasmic reticulum interactions

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 754, С. 151555 - 151555

Опубликована: Фев. 26, 2025

Язык: Английский

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Chitosan-tripolyphosphate nanoparticles as a novel vehicle for DNA vaccine delivery: combatting Aeromonas hydrophila in zebrafish

Aquaculture International, Год журнала: 2025, Номер 33(3)

Опубликована: Март 21, 2025

Язык: Английский

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Preparation and characterization of PVA/chitosan nanofibers loaded with Dragon's blood or poly helixan as wound dressings

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 272, С. 132844 - 132844

Опубликована: Июнь 1, 2024

Язык: Английский

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