Preparation and characterization of PVA/chitosan nanofibers loaded with Dragon's blood or poly helixan as wound dressings DOI
Maral Mahboubi Kancha, Mohsen Mehrabi,

Faeze Aghaie

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132844 - 132844

Published: June 1, 2024

Language: Английский

Evaluating the antibacterial effect of meropenem-loaded chitosan/sodium tripolyphosphate (TPP) nanoparticles on Acinetobacter baumannii isolated from hospitalized patients DOI Creative Commons

Marziyeh Sadat Amini,

Majid Baseri Salehi,

Nima Bahador

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 24, 2024

Abstract Background Acinetobacter baumannii is a health threat due to its antibiotic resistance. Herein, susceptibility and association with the Toxin-antitoxin (TA) system genes in A. clinical isolates from Iran were investigated. Next, we prepared meropenem-loaded chitosan nanoparticles (MP-CS) investigated their antibacterial effects against meropenem-susceptible bacterial isolates. Methods Out of 240 specimens, 60 assessed. Antibiotic resistance conventional antibiotics was determined alongside investigating presence three TA ( mazEF , relBE higBA ). Chitosan characterized terms size, zeta potential, encapsulation efficiency, meropenem release activity. Their assessed using well diffusion method, minimum inhibitory concentration (MIC), colony-forming unit (CFU) counting. cytotoxic biocompatibility index via MTT, LDH, ROS formation assays. Results Ampicillin, ceftazidime, colistin least effective, amikacin tobramycin most effective antibiotics. isolates, 10 (16.7%), 5 (8.3%), 45 (75%) multidrug-resistant (MDR), extensively drug-resistant (XDR), pandrug-resistant (PDR), respectively. had no significant effect on MP-CS demonstrated an average size 191.5 potential 27.3 mV maximum efficiency 88.32% rate 69.57%. mediated similar effects, as compared free meropenem, significantly lower levels meropenem. remarkably prevented A549 NCI-H292 cell infection by demonstrating favorable index. Conclusion Antibiotic-loaded should be further designed increase assess safety applicability vivo settings.

Language: Английский

Citations

4
Berberine-loaded albumin nanoparticles alleviate liver damage in rats by modulating mitochondrial biogenesis and mitochondria-endoplasmic reticulum interactions DOI

Heba Zaied,

Mohamed I Ashmawy, Ahmed E. Abdel Karim

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 754, P. 151555 - 151555

Published: Feb. 26, 2025

Language: Английский

Citations

0
Chitosan-tripolyphosphate nanoparticles as a novel vehicle for DNA vaccine delivery: combatting Aeromonas hydrophila in zebrafish DOI

Pradisha Prem,

Chinnaperumal Kamaraj, S. Vimal

et al.

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(3)

Published: March 21, 2025

Language: Английский

Citations

0
Preparation and characterization of PVA/chitosan nanofibers loaded with Dragon's blood or poly helixan as wound dressings DOI
Maral Mahboubi Kancha, Mohsen Mehrabi,

Faeze Aghaie

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132844 - 132844

Published: June 1, 2024

Language: Английский

Citations

1