Lipid Nanoparticles Carrying Essential Oils for Multiple Applications as Antimicrobials
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 178 - 178
Опубликована: Янв. 31, 2025
Lipid
nanoparticles
(LNPs)
are
versatile
delivery
systems
with
high
interest
because
they
allow
the
release
of
hydrophobic
and
hydrophilic
molecules,
such
as
essential
oils
(EOs)
plant
extracts.
This
review
covers
published
works
between
2019
2024
that
have
reported
use
EO-based
LNPs
antimicrobial
properties
applications
in
human
animal
health,
well
biopesticides.
In
healthcare
field,
reports
addressed
effect
encapsulating
EOs
lipid
nanosystems
antiviral,
antibacterial,
antiprotozoal
antifungal
activities.
care,
this
still
needs
to
be
more
deeply
explored
while
looking
for
sustainable
alternatives
against
different
types
parasites
affect
health.
Overall,
antibacterial
activities
carrying
described
synthetic
antibiotics.
field
agriculture,
studies
showed
these
approaches
control
phytopathogens
other
pests
food
production.
There
is
a
growing
demand
innovative
technologies.
However,
there
some
challenges
overcome
order
innovations
reach
market.
Язык: Английский
SLN and chitosan nano-delivery systems for antibacterial effect of black seed ( Nigella sativa) oil against S. aureus
International Journal of Environmental Health Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 12
Опубликована: Июль 21, 2024
with
current
universal
importance
represents
a
main
carrier
of
emerging
antimicrobial
resistance
determinatives
global
health
concerns
that
have
developed
drug
mechanisms
to
the
various
available
antibiotics.
On
other
hand,
due
potential
Язык: Английский
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II – applications and preclinical advancements
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Numerous
purified
bioactive
compounds,
crude
extracts,
and
essential
oils
have
demonstrated
potent
antioxidant,
antimicrobial,
anti-inflammatory,
antiviral
properties,
particularly
in
vitro
or
silico;
however,
their
vivo
applications
are
hindered
by
inadequate
absorption
distribution
the
organism.
The
incorporation
of
these
phytochemicals
into
solid
lipid
nanoparticles
(SLN)
nanostructured
carriers
(NLC)
has
significant
advancements
represents
a
viable
approach
to
improve
bioavailability
through
different
administration
routes.
Язык: Английский
Soothing the Itch: The Role of Medicinal Plants in Alleviating Pruritus in Palliative Care
Plants,
Год журнала:
2024,
Номер
13(24), С. 3515 - 3515
Опубликована: Дек. 16, 2024
Chronic
pruritus,
or
persistent
itching,
is
a
debilitating
condition
that
severely
impacts
quality
of
life,
especially
in
palliative
care
settings.
Traditional
treatments
often
fail
to
provide
adequate
relief
are
associated
with
significant
side
effects,
prompting
interest
alternative
therapies.
This
review
investigates
the
antipruritic
potential
eight
medicinal
plants:
chamomile
(Matricaria
chamomilla),
aloe
vera
(Aloe
barbadensis),
calendula
(Calendula
officinalis),
curcumin
(Curcuma
longa),
lavender
(Lavandula
angustifolia),
licorice
(Glycyrrhiza
glabra),
peppermint
(Mentha
piperita),
and
evening
primrose
(Oenothera
biennis).
These
plants
analyzed
for
their
traditional
applications,
active
bioactive
compounds,
mechanisms
action,
clinical
evidence,
usage,
dosage,
safety
profiles.
Comprehensive
searches
were
conducted
databases
including
PubMed,
Web
Science,
Scopus,
b-on,
focusing
on
vitro,
animal,
studies
using
keywords
like
“plant”,
“extract”,
“pruritus”.
Studies
included
regardless
publication
date
limited
English-language
articles.
Findings
indicate
compounds
such
as
polysaccharides
vera,
curcuminoids
turmeric,
menthol
exhibit
anti-inflammatory,
antioxidant,
immune-modulating
properties.
Chamomile
alleviate
itching
through
anti-inflammatory
skin-soothing
while
offer
antimicrobial
benefits
alongside
relief.
Evening
primrose,
rich
gamma-linolenic
acid,
effective
atopic
dermatitis-related
itching.
Despite
promising
preclinical
results,
challenges
remain
standardizing
dosages
formulations.
The
highlights
necessity
further
trials
ensure
efficacy
safety,
advocating
integrating
these
botanical
therapies
into
complementary
practices.
Such
approaches
emphasize
holistic
treatment,
addressing
chronic
pruritus’s
physical
emotional
burden,
thereby
enhancing
patient
well-being.
Язык: Английский
Potential advancement utilizing nanotechnology-based delivery system to enhance the therapeutic properties of lavender essential oil: a review article
A.M. Bagas Trianloka,
Lutfi Chabib,
Arba Pramundita Ramadani
и другие.
Jurnal Ilmiah Farmasi (Scientific Journal of Pharmacy),
Год журнала:
2024,
Номер
20(2), С. 231 - 243
Опубликована: Дек. 31, 2024
Background:
Essential
oils
(EO),
such
as
lavender
(Lavandula
spp.),
which
are
derived
from
its
flower,
have
become
a
growing
trend
in
recent
years
an
alternative
medicine
therapy.
However,
the
poor
physicochemical
properties
of
EOs
several
disadvantages
for
their
application.
Integrating
nanotechnology
into
formulation
medicinal
dosage
forms
may
provide
viable
way
to
mitigate
these
limitations
and
improve
effectiveness
EO
utilization.Objective:
This
literature
review
aims
gather
information
on
benefits
prospective
applications
nanotechnology-based
delivery
systems
EOs.Method:
Online
databases
PubMed,
Science
Direct,
Research
Gate,
Google
Scholar,
other
reliable
sources
were
used
find
65
publications
between
1991
2021,
assessed
this
review.Results:
It
is
revealed
that
main
constituents
linalool,
linalyl
acetate,
lavandulyl
acetate.
Its
antibacterial,
antioxidant,
anticancer,
anti-anxiety,
having
effects
central
nervous
system,
along
with
qualities
including
pain
relief,
has
been
demonstrated
via
numerous
studies.
Additionally,
it
was
dermatological
helped
treat
dermatitis
encouraged
both
hair
growth
wound
healing.
Furthermore,
also
found
application
improved
concentration
active
compounds
blood
produced
stable
form
while
increasing
efficacy.Conclusion:
feasible
create
nanoparticle
can
substance's
solubility,
stability,
pharmacological
effects.
More
research
necessary
formulate
by
applying
nanotechnology.
Язык: Английский
Antibacterial effects of thyme oil loaded solid lipid and chitosan nano-carriers against Salmonella Typhimurium and Escherichia coli as food preservatives
PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0315543 - e0315543
Опубликована: Дек. 31, 2024
Objectives
Escherichia
coli
and
Salmonella
Typhimurium
are
frequent
causes
of
foodborne
illness
affecting
many
people
annually.
In
order
to
develop
natural
antimicrobial
agents
against
these
microorganisms,
thyme
oil
(TO)
was
considered
as
active
antibacterial
ingredient.
TO
contains
various
bioactive
compounds
that
exhibit
properties.
To
increase
the
effects
stability
oil,
two
promising
carrier
systems,
solid
lipid
nanoparticles
(SLN)
chitosan
have
been
fabricated
in
this
study.
Methods
Nanoparticles
were
made
using
natural-based
lipids
polymers
by
a
probe
sonication
method.
They
characterized
infrared
spectrometry
(FTIR),
transmission
electron
microscopy
(TEM),
particle
size,
cytotoxicity,
etc.
Antibacterial
TO,
loaded
SLN
(TO-SLN)
nanoparticle
(TO-CH)
evaluated
E
.
S
typhimurium
Minimum
inhibitory/bactericidal
concentrations
(MIC/MBC)
determination.
Encapsulation
efficiency
(EE%)
drug
release
profile
also
studied
vitro
Results
TEM
analysis
revealed
spherical/ovoid-shaped
particles
with
clear
edges.
TO-SLN
had
an
average
size
42.47nm,
while
TO-CH
144.8nm.
The
TO–CH
TO–SLN
about
81.6±1%
73.4±1%,
respectively.
indicated
92%
cumulative
comparison
88%
72
h.
MIC
for
TO-CH,
TO-SLN,
pure
4
1.5
μg/mL,
60
40
180–150
Conclusion
Nanoencapsulation
significantly
potentiated
its
effects.
exhibited
higher
effect
compared
(6-fold)
(more
than
10-fold).
Язык: Английский